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Showing 1 to 20 of 44 for “"ARNT"”.

  1. Evidence that ARNT plays a role in the regulation of the immunoglobulin heavy chain enhancer and identification of a putative ARNT ligand

    Yavrom, Sheena2018

    … In our study we tested the function of ARNT (Ah receptor nuclear translocator) at the IgH (immunoglobulin heavy chain) enhancer. We were able to determine that ARNT appears to partially down-regulate activation at the IgH enhancer by Pan-1 in transient transfection assays by …

    u-pacific Repository record

  2. Investigation of ARNT isoform-specific regulation of AHR signaling

    Bourner, LukeThe University of Texas Medical Branch at Galveston2021

    … aryl hydrocarbon receptor nuclear translocator (ARNT) is alternatively spliced into two distinct isoforms, isoform 1 and 3. Although ARNT is found to be critical in immunity, xenobiotic, and hypoxic response, ARNT isoform-specific function has yet to be investigated. We previously demonstrated …

    utmb Repository record

  3. Structural Characterization and Chemical Inhibition of the ARNT/TACC3 Complex

    Guo, Yirui2017

    … hypoxia response, directly interacting with the ARNT subunit of HIF in a novel and promoter-specific way. However, misregulation by overexpression or activating fusions (for example, FGFR-TACC3) is sufficient for transformation and associated with the development of glioblastoma, renal cell …

    utswmed Repository record

  4. Mechanistic study of aryl hydrocarbon receptor nuclear translocator (ARNT)-mediated signaling

    Wang, Yu2018

    … aryl hydrocarbon receptor nuclear translocator (ARNT)-interacting peptide (Ainpl) was characterized from human liver cDNA library using phage display. Ainpl suppresses hypoxia inducible factor-1a (HIF-1α) signaling pathway through an ARNTdependent manner. HIF-1α is known to be overexpressed in …

    u-pacific Repository record

  5. ARNT isoforms differentially regulate cancer cell growth through a p53-dependent mechanism.

    Sarkar, KrishnakaliThe University of Texas at Austin2014

    Aryl hydrocarbon receptor nuclear translocator (ARNT) is an important player in xenobiotic and hypoxic responses. In addition to this, my mentor has shown that ARNT is an integral cofactor of NF-kB signaling. However, these initial observations of ARNT-mediated NF-kB modulation were based on …

    texas Repository record

  6. Myeloid-Specific ARNT Signaling Drives Sex-Based Differences in Acrolein-Induced Pulmonary Toxicity

    Tanner, Madison Gabrielle 1991-The University of Texas Medical Branch at Galveston2025

    … investigates the role of myeloid-specific ARNT in modulating the pulmonary immune response to acrolein, a highly reactive environmental toxicant. Using a murine model with myeloid-specific overexpression of Arnt-a (homolog of human ARNT isoform 1), this study characterizes both the both the …

    utmb Repository record

  7. Using affinity purification -- mass spectrometry to identify aryl hydrocarbon receptor nuclear translocator interacting proteins

    Madian, Ashraf G.2005

    <p>The aryl hydrocarbon nuclear translocator (ARNT) belongs to the family of basic helix loop helix proteins. ARNT forms a heterodimer with aryl hydrocarbon receptor (AhR). This heterodimer binds to the dioxin responsive element (DRE) causing the regulation of the gene expression of some enzymes …

    u-pacific Repository record

  8. Environmental signals that control T lymphocytes in the gastrointestinal tract

    Ramsay, GeorgeUniversity of Dundee2015

    … Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) binds the Aryl Hydrocarbon Receptor (AHR) and also the Hypoxia Inducible Factor-1α (HIF-1α). Both the AHR and HIF-1α are key sensors of the microenvironment. Dietary tryptophan metabolites and microbiota catabolites are AHR ligands and HIF-1α …

    dundee Repository record

  9. Exploring the role and the function of Aryl Hydrocarbon Receptor (AhR) and Aryl Hydrocarbon Nuclear Translocator (ARNT) in T cells

    Rosenzweig, EllaUniversity of Dundee2012

    … and the Aryl Hydrocarbon Nuclear Translocator (ARNT) play a role in mediating transcriptional responses to environmental pollutants, including the highly toxic compound 2,3,7,8-tetrachlorodibenzo -p-dioxin (TCDD) but also endogenous physiological ligands. More recent studies have also indicated …

    dundee Repository record

  10. Analysis of the Role of bHLH/PAS Proteins in Aryl Hydrocarbon Receptor Signaling

    Dougherty, Edward JDigital Commons @ University of South Florida2008

    … receptor (AHR) is a basic helix-loop-helix PER/ARNT/SIM (bHLH-PAS) transcription factor that binds ligands typified by 2,3,7,8-tetracholordibenzo-p-dioxin, translocates to the nucleus, dimerizes with the aryl hydrocarbon nuclear translocator (ARNT) and associates with specific cis xenobiotic …

    usf Repository record

  11. A Fragile Native State Structure: An Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) Variant Exhibits Slow Interconversion Kinetics Between two Different Folds

    Evans, Matthew Ryan2010

    … aryl hydrocarbon receptor nuclear translocator (ARNT) is a promiscuous basic helix-loop-helix Period/ARNT/Single-minded (bHLH-PAS) protein that controls various biological pathways by forming heterodimeric transcriptional regulator complexes with several other bHLH-PAS proteins via the beta-sheet …

    utswmed Repository record

  12. Study of the aryl hydrocarbon receptor as a target for rational drug design

    Xie, Jinghang2018

    … aryl hydrocarbon receptor nuclear translocator (Arnt) for transcriptional regulation. We generated three N-terminal deletion constructs of the human AhR of 12-24 KDa in size—namely D1 (aa 84-295), D2 (aa 84-192) and D3 (aa 191-295)—to suppress the Arnt function. We observed that all three …

    u-pacific Repository record

  13. Bacterial expression of radio-labeled recombinant proteins for studying AHR signalling

    Delucchi, Anthony Benjamin2001

    … with the Aryl Hydrocarbon Nuclear Translocator (ARNT) in response to planar aromatic hydrocarbons. In addition to AHR and ARNT there are at least three other proteins involved in AHR signaling. These proteins are the co-chaperone p23, Ara-9 and two molecules of Heat Shock Protein-90 (HSP-90). …

    u-pacific Repository record

  14. Investigating mechanisms and biological functions of the bHLH/PAS transcription factors SIM1 and ARNT2

    Gerassimou, Alexis Georgia2021

    The basic Helix-Loop-Helix/PER-ARNT-SIM (bHLH/PAS) family of transcription factors are involved in gene regulation during both embryonic development and throughout adulthood to maintain cellular homeostasis. Members of this family must heterodimerise to activate or repress target gene expression. …

    adelaide Repository record

  15. Characterization of Aryl Hydrocarbon receptor and Kruppel-Like-Factor-6 interaction

    Pereira De Castro, Karen LarissaThe University of Texas Medical Branch at Galveston2021

    … Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT). The canonical AhR-ARNT complex binds to DNA regions known as Xenobiotic Response Elements (XRE), inducing the transcription of target genes. Our previous results demonstrated that the AhR is also involved in a novel protein-DNA complex with …

    utmb Repository record

  16. Analysis of the aryl hydrocarbon receptor and a truncated form (AHR C[upper case symbol for greek Delta]Δ553) in cancer cells

    Chow, Marilynn2011

    … aryl hydrocarbon receptor nuclear translocator (Arnt), in the nucleus to initiate the expression of proteins involved with detoxification. Published work suggests cross-talk between both proteins and cellular pathways involving the transcription factors, HIF -1 , ER, and NFKB, whose activity is …

    u-pacific Repository record

  17. Overexpression of Human Aryl Hydrocarbon Receptor in <i> E.coli</i> Using Two Different Solubility Enhancing Tags

    Tejomurthula, Sravanthi2018

    … the AhR dimerizes with AhR nuclear translocator (Arnt), the chaperone proteins in the complex get dissociated followed by the activation of transcription of various genes such as CYP1A1 and CYP1A2 by AhR-ARNT heterodimer. Various cancers have altered levels of AhR in the absence of ligand. Our …

    u-pacific Repository record

  18. Hypoxic Influences On Myeloid Cells During Inflammation And Inflammation-Associated Cancer

    Lin, Nan2018

    … is investigated by depleting myeloid ARNT, the obligate heterodimeric binding partner for both HIF-α subunits, in a dextran sodium sulfide-induced murine acute colitis model. Myeloid pan-HIF deficiency exacerbates infiltration of pro-inflammatory neutrophils and monocytes into inflamed …

    penn Repository record

  19. The Role of Von Hippel-Lindau Protein in the Glomerulus

    Ding, Mei2010

    … hydrocarbon receptor nuclear translocator gene (Arnt, also called HIF1beta), an obligate dimerization partner for HIFα subunit function. Podocyte-selective deletion of Arnt in Vhlh mutant mice completely rescued the RPGN phenotype and mice survived longer than 8 months of age. Furthermore, …

    toronto-retro Repository record

  20. Male Subfertility and Prostate Cancer Risk: Epidemiological and Genetic Studies

    Ruhayel, YasirLund University, Faculty of Medicine2012

    … its partner molecule AHR nuclear translocator (ARNT), and estrogen receptor beta (ESR2), as well as a number of other genes, of which poly (ADP-ribose) polymerase 2 (PARP2) showed the most robust association. We conclude that: 1) longer GGN repeat lengths may be associated with cryptorchidism …

    lund Repository record

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