Global ETD Search
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Showing 1 to 2 of 2 for “"ARH3"”.
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Chemical approaches to understanding small-molecule accumulation in bacteria and poly(ADP-ribosyl)ation
… activity of the major PAR degraders (PARG and ARH3). Towards filling this need, novel fluorogenic substrates of PARG and ARH3 were designed and synthesized. Using these tools, the first continuous enzyme activity assays for PARG and ARH3 were developed for use with purified enzymes and in cell …
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High-throughput screening for ADP-ribosyl hydrolase 3 inhibitors
… tool compound to study the activity of ARH3, a key degrader of PAR and MAR. Toward filling this need, a high-throughput screen was conducted using a fluorogenic substrate to discover an inhibitor of ARH3. A total of 496 primary hits have been identified and will be further studied to …