Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"ARFGEF3"”.
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Investigation of the role of ARFGEF3 in breast to brain metastasis
… Sanger sequencing confirmed the mutation of ARFGEF3 in BBM samples. We assume that the loss of ARFGEF3 in a breast cancer cell line contributes to brain metastasis. Further investigation on the role of ARFGEF3 revealed its influence in controlling the expression of lysosomes (LAMP1) in …
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ARFGEF mutations: A mechanism for breast-to-brain metastasis
… metastasis (BBM) cancers identified ARFGEF3 mutations in the BBM samples. This suggests that the absence of ARFGEF3 in breast cancer cells plays a role in the development of brain metastasis. The research presented here aims to uncover the molecular mechanisms underlying the …
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A New Approach To Identifying Effectors and Regulators of Small GTPases
… microscopy, namely with the Rab GTPases Rab2A (ARFGEF3/BIG3, STAMBPL1), Rab5A (OSBPL9, TBCK), Rab9A (HPS3, NDE1), and Rab11A/B (ALS2). Furthermore, numerous novel interactors were identified for Rab1A and Rab1B, two mammalian paralogues of the yeast protein Ypt1 that are known to be key …