Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 63 for “"ARDS"”.
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Targeting Endothelial Pathological Calcium Signaling Accelerates Resolution of SARS-CoV-2-Induced ARDS
Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by diffuse alveolar damage, pulmonary edema, and severe hypoxemia, with limited therapeutic options. Increasing evidence identifies endothelial dysfunction and vascular barrier disruption as central drivers of …
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ASpirin as a treatment for ARDS (STAR): a phase 2 randomised controlled trial
… <br/>Acute respiratory distress syndrome (ARDS) remains a common cause of significant mortality and morbidity for which there is currently no pharmacological treatment. Platelets play an important role in the pathophysiology of ARDS. There is in vivo, in vitro, observational and clinically …
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The role of inflammasomes in a murine model of acute respiratory distress syndrome (ARDS)
… caused by sepsis, severe pneumonia and trauma. ARDS has become one of the top research priorities since the SARS-CoV-2 outbreak in 2020. From injury to damaged tissue repair, cell proliferation is a mandatory mechanistic process which is triggered by neutrophils and tissue resident macrophages …
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Ο ρόλος των κυκλοφορούντων miRNA ως προγνωστικοί βιοδείκτες στην ανάπτυξη και τη θνητότητα του Συνδρόμου Οξείας Αναπνευστικής Δυσχέρειας (ARDS)
… Το σύνδρομο οξείας αναπνευστικής δυσχέρειας (ARDS) αποτελεί ένα συστηματικό σύνδρομο με υψηλή νοσηρότητα και θνητότητα. Η ετερογένεια του συνδρόμου, η καθυστερημένη αναγνώριση και η έλλειψη ευαίσθητων προγνωστικών δεικτών καθιστούν αναγκαία την αναζήτηση νέων βιοδεικτών για τον καλύτερο …
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The effects of mechanical ventilation on the development of Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome (ARDS) is a severe lung illness characterized by inflammation and fluid accumulation in the respiratory system. Historically, ARDS and other forms of respiratory failure have been treated using mechanical ventilation to help maintain gas exchange in the lungs. …
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Identification of novel coding single nucleotide polymorphisms associated with acute respiratory distress syndrome
ARDS is a lung condition characterized by impaired gas exchange with systemic release of inflammatory mediators, causing inflammation, hypoxemia and multiple organ failure. Disease susceptibility and progression are poorly understood and there are few effective therapeutic options. Existing …
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Cathepsin S as a mediator of acute lung inflammation
The acute respiratory distress syndrome (ARDS), first described over half a century ago, is a common and catastrophic syndrome that develops in critically ill patients. ARDS is characterised by the flooding of the alveoli with protein- and leukocyte-rich, non-cardiogenic oedema and refractory …
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Incidence and Pathogenesis of Acute Lung Injury and the Acute Respiratory Distress Syndrome in Humans
… form, acute respiratory distress syndrome (ARDS), are conditions characterised by neutrophilic pulmonary inflammation, refractory hypoxaemia and diffuse alveolar damage. This work reports on the first UK based prospective study of the incidence and longer term mortality of ALI/ARDS in a …
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High flow nasal oxygen versus mechanical ventilation as initial respirator support in severe COVID-19 ARDS at Groote Schuur Hospital : a propensity score analysis
… acute respiratory distress syndrome (ARDS). Survival rates in the “HFNO first” cohort were significantly higher, even in those that subsequently required ventilation, compared to the “MV first” strategy. This study adds important evidence to the debate on the potential benefits and …
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Endotype Discovery in Acute Respiratory Distress Syndrome
… Samanta Acute respiratory distress syndrome (ARDS) affects 10% of critical care patients and is characterised by acute refractory hypoxaemia and bilateral pulmonary infiltrates on thoracic imaging. Mortality from severe ARDS is approximately 40%, and has not changed in 50 years despite decades …
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Can Cognitive Behavioural Techniques Reduce Exercise Anxiety and Improve Adherence to a Resistance Training Program for People with Anxiety-Related Disorders?
Anxiety-related disorders (ARDs) are highly prevalent and associated with substantial functional impairment, including poor health outcomes and economic burden. Exercise is a cost-efficient alternative to other treatments for ARDs (e.g., psychotherapy, pharmaceutical) that is also associated with …
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Ketogenic Diet is Protective During Endotoxin-Induced Lung Injury
<p>Acute respiratory distress syndrome (ARDS) is a lung condition caused by uncontrolled lung inflammation with excessive immune cell infiltration, which eventually leads to severe pulmonary edema and poor oxygenation. ARDS affects hundreds of thousands of people a year, particularly those …
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Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome
The Acute Respiratory Distress Syndrome (ARDS) is a devastating clinical disorder characterised by excessive inflammation in the alveolar compartment resulting in oedema of the airspaces due to loss of integrity in the alveolar epithelial-endothelial barrier. ARDS is associated with high mortality …
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A review of the use of inhaled nitric oxide in the PICU at Red Cross Children's Hospital, 2011-2015: A retrospective cohort study
… in acute respiratory distress syndrome (ARDS) and pulmonary hypertension (PHT) following cardiac surgery. Objectives: To describe the response to treatment with iNO. Secondary observations were deaths, comorbidities of the patients treated, lengths of treatment and admission, and the cost …
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Outcomes of patients with COVID-19 Acute Respiratory Distress Syndrome requiring Invasive Mechanical Ventilation admitted to an Intensive Care Unit in South Africa
… low- and middle-income countries for COVID-19 ARDS are limited. Groote Schuur Hospital in Cape Town, South Africa expanded its ICU service to support patients with COVID-19 ARDS requiring invasive mechanical ventilation (IMV). We report on patients' characteristics and outcomes from two …
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Effects of hypercapnic acidosis on the primary cells relevant to acute respiratory distress syndrome pathophysiology and the therapeutic potential of Mesenchymal Stem Cells
Acute Respiratory Distress Syndrome (ARDS) is an inflammatory disorder in which the integrity of the alveolar epithelial-capillary endothelial barrier breaks down, facilitating the accumulation of a protein-rich oedema fluid within the alveoli. Despite years of clinical trials, no effective …
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The Balance of Interferon-γ and Interleukin-10 during Influenza A Virus Infection Complicated by Methicillin-Resistant Staphylococcus aureus Superinfection
… of acute respiratory distress syndrome (ARDS). ARDS is a highly lethal inflammatory lung injury that is associated with dysregulated cytokine production and decreased lung compliance. No specific treatment exists for ARDS due to the limited understanding of its pathogenesis. We have …
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Inhibition of Margination and Diapedesis of Neutrophils by Protein Synthesis Blockade
Acute Respiratory Distress Syndrome (ARDS), an age-old clinical problem facing the Emergency Department and Intensive Care Units of all health systems, is a common debilitating lung condition consequent upon severe systemic inflammation. Although several studies have gone into understanding the …
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Lung microenvironment plays a key role on the protective vs. detrimental effects of mesenchymal stromal cell therapy in acute lung injury
Acute respiratory distress syndrome (ARDS) is a complex disorder with high mortality. Most ARDS non-survivors present complications of pulmonary fibrosis. Mesenchymal stromal cells (MSC) are considered good candidates for therapy due to their ability to home into injury sites and help in recovery. …
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