Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"AR antagonists"”.
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Antioxidant Programs Are Essential for Enzalutamide-Resistant Prostate Cancer
… to second generation androgen receptor (AR) antagonists, such as enzalutamide, is common in patients with advanced prostate cancer (PCa). In order to identify which patients will develop therapy resistance and the underlying cause, it is critical to characterize detailed mechanisms of …
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Androgen Receptor and Prostate Cancer Cell Heterogeneity
<p>Androgen receptor (AR) plays an important role in prostate cancer (PCa) development and has been the main therapeutic target in advanced PCa. AR expression is heterogeneous in both primary PCa and castration resistant prostate cancer (CRPC). However, the functional significance of AR …
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CaV1.3 Ion channel expression and hormone therapy in prostate cancer
… disease and the most common cancer in UK males. Early localised PCa is commonly treated with radiotherapy or surgery where recurrent tumours are treated with hormone therapy, such as androgen-deprivation therapy (ADT) and/or androgen receptor (AR) antagonists, e.g. Enzalutamide (ENZ). …
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Small molecule inhibitors of steroid receptors for breast and prostate cancer
… cancers. This thesis aimed at identifying and characterizing new chemical entities with therapeutic potential in breast and prostate cancer treatment. Reported here are two inhibitors that antagonize androgen receptor (AR) function and one that suppresses estrogen receptor (ER) signaling. …
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Characterisation of novel alpha1-adrenoceptor ligands
α1A-adrenoceptor (AR) antagonists used clinically to treat urogenital conditions, such as benign prostatic hyperplasia, have side effects due to a lack of subtype selectivity and the 5-HT1A-R off-target affinity. In this study, computer-aided drug design, structure-activity relationship, and …
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Androgen Receptor: A Complex Therapeutic Target in Breast Cancer
… is classified based on the expression of three markers estrogen receptor (ER), progesterone receptor, and human epidermal growth factor receptor (HER2). Breast cancers that express these targets are classified as hormone receptor (HR) positive breast cancer and the tumors that lack the expression …
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Drug discovery at class A and class B GPCRs
G protein-coupled receptors (GPCRs) are a big family of membrane receptors encoded by more than 800 genes in humans. The vast number and diversity of GPCRs enables them to interact with an equally great number of ligands enabling them to regulate many physiological functions such as senses, …
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The role of SRC family kinases in the development and progression of prostate cancer
… the development of the disease for 2 years in average. Virtually all patients, undergoing androgen deprivation therapy eventually develop castration-resistant prostate cancer. Currently, only taxane class of drugs has been proven to provide short survival advantage in patients with …