Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 2 of 2 for “"AQX-1125"”.
-
Thioetherification and Etherification Utilizing Trichloroacetimidates Under Thermal Conditions & Progress Towards an Efficient Synthesis of AQX-1125
… total synthesis towards the SHIP1 activator AQX-1125 from trans-dehydroandrosterone has been studied. The synthetic approach features an allylic oxidation of the C7 position and ozonolysis to generate key intermediates. Alternative routes have also been proposed and future investigations will …
-
Synthetic Studies on Small Molecule Modulators of Src Homology 2 (SH2) Domain-Containing Inositol 5’-Phosphatase (SHIP)
… studies have culminated in the identification of AQX-1125, which is currently undergoing phase III clinical evaluation for interstitial cystitis / bladder pain syndrome. To facilitate our own studies on SHIP1 signaling, a new synthetic route to the SHIP1 agonist AQX-1125 has been developed. This …