Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"AQP4"”.
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The mechanisms of aquaporin expression and translocation in cerebral pathologies
… AQPs have been highlighted as key drug targets. AQP4 is the most abundant AQP in the central nervous system (CNS), predominantly in CNS glial cells, particularly astrocytes and at the blood-brain barrier. Astrocytes are the most abundant cells in the CNS and are a major site of stroke or …
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Aquaporin 4 and Kir4.1 Distribution in Retinal Glial Cells of Normal Macaque Eyes and Eyes with Experimental Glaucoma
… to determine the distribution of aquaporin 4 (AQP4) and a potassium inward rectifying channel (Kir4.1) in the Müller glia and astrocytes of the normal macaque monkey retina and to see how the distribution changed in eyes with experimental glaucoma. Methods: Five Rhesus macaque monkeys, ranging …
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Role of Astrocyte Network in Edema after Juvenile Traumatic Brain Injury
… central role in the edema process: Aquaporin 4 (AQP4) and Connexin 43 (Cx43). AQP4 is expressed extensively in astrocyte endfeet, which surrounds the blood vessels as part of the blood brain barrier (BBB). Cx43 is central in astrocyte to astrocyte connection and communication. We hypothesized …
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Aquaporin-4 mediates blood brain barrier permeability during endotoxemia
Aquaporin-4 (AQP4) is a water channel expressed on astrocytes known to regulate the exchange of fluids and solutes between the parenchyma of the central nervous system (CNS) and perivascular spaces. We hypothesized that activation of AQP4 may mediate permeability of the CNS during systemic …
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Oxygen resuscitation does not ameliorate neonatal hypoxia/ischemia-induced edema
… level, we investigated the effect of HI on AQP4, the main water channel in the brain, which has been implicated in edema development after different neuropathological conditions. Our results showed that HI significantly increased AQP4 levels 3, 7 and 21 days after HI in the ipsilateral …
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An <i>in vitro</i> human 3D co-culture model to study endothelial-astrocyte interactions
… fibrillary acidic protein (GF AP), aquaporin-4 (AQP4), endothelin-l (Et-l) and endothelin receptor type-B (EDNRB), were compared between 3D and 2D cultured HA. The decreased expression of AQP4 and EDNRB and the much-decreased proliferation rate of 3D HA suggested their reduced reactivity and a …
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Caracterización clínica de pacientes con trastornos del espectro de neuromielitis óptica en la ciudad de Bogotá - Colombia
… de estas variables según seropositividad del Ac-AQP4. Resultados: Se incluyeron 26 pacientes con NMO/NMOSD (18 mujeres, mediana de edad de 53.5 años; P25-P75= 40.5-58.0, todos de raza mestiza). La mediana de edad de inicio fue de 46.5 años (P25-P75=34.2-54.0), la mayoría de los pacientes tuvo …
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Characterizing Changes in the Brain During Hydrocephalic Development and Exploring Potential Treatment Strategies
… (AQP), aquaporin-1 (AQP1) and aquaporin-4 (AQP4), important in regulating CSF and interstitial fluid (ISF). Increased fluorescent intensity of AQP4 in the subventricular zone and increased AQP1 apical localization and protein amount in the CP was observed in hydrocephalic animals at …
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NEUROBIOLOGIA DEL SUICIDIO NEL DISTURBO DEPRESSIVO MAGGIORE: STUDIO MORFOLOGICO POST-MORTEM PER L¿INDAGINE DEL NETWORK GLIALE E VASCOLARE, CON ANALISI TOSSICOLOGICHE PER LA VALUTAZIONE DELL¿ADERENZA ALLA TERAPIA PSICHIATRICA
… – , S100β – calcium binding protein S100β –, AQP4 – Aquaporin-4 –, ALDH1L1 – Aldehyde Dehydrogenase 1 Family Member L1) showed a trend toward increased cell number and marker expression in suicide cases, particularly in the dorsolateral prefrontal cortex (dlPFC) and white matter. GFAP/S100β …
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An audit of the epidemiological, clinical features and outcomes of patients with Neuromyelitis Optica Spectrum Disorder (NMOSD) attending a South African Tertiary referral Hospital
… attacks. Moreover, 51% of patients with AQP4-Ab-positive serology captured by the PGWC Data Centre did not attend the referral neurology service. The demographic profiles of our cohort were similar to others that have been reported. Most of our patients were young women of non-European …
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Molecular Mechanisms of Gating, Selectivity, and Transport in Membrane Channels and Carriers
… the permeability of mammalian AQP1 and AQP4 to O2, CO2 and NO. Apart from water, these AQPs are found to provide pathways for gas molecules to cross biological membranes. Additionally, the phosphorylation-mediated gating of a plant aquaporin is investigated. Opening of the water channel …
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Differentielle Expression und Funktion eines glialen Kaliumkanals (K<sub>ir</sub>4.1, KCNJ10) im Rückenmark und Bedeutung in einem neurodegenerativen Krankheitsmodell
… Kolokalisation von Kir4.1 und einem Wasserkanal (AQP4) auf astroglialen Endfüßen nachgewiesen werden. Das Kir4.1-Expressionsmuster im Rückenmark legt eine Rolle des Kanals in der Kaliumpufferung und möglicherweise in der Kalium-gesteuerten Volumenregulation nahe.Basierend auf den Ergebnissen der …
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Drug design strategies for modulating immune activity for the treatment of autoimmune diseases and cancer
… platform that can be used to screen for anti-AQP4 autoantibodies found in patients with neuromyelitis optica (NMO). This platform may be used to help develop targeted therapeutics that selectively suppress disease-related immune cells for the treatment of autoimmune diseases such as NMO. Due …
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Genetic exploration of exercise associated sudden death in racehorses
… human ion channelopathy genes, aquaporin 4 (AQP4) and potassium channel tetramerization domain containing 1 (KCTD1) on the region in chromosome 8, showed potential relevance to dysrhythmia development. Specific Aim 2: This study aimed to identify causative variants in arrhythmogenic candidate …
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DISSECTING IMMUNE DYSREGULATION IN PATIENTS WITHTHYMIC EPITHELIAL TUMORS BY AUTOANTIBODY ANDSINGLE-CELL PROFILING
… characterized by anti-dsDNA, anti-IL-12, anti-AQP4 and anti-TIF1γ autoAbs with strong internal correlations. In contrast, IgM autoreactivity was reduced in AB and B thymomas yet increased in TH, consistent with sustained unswitched memory B cells and long-term IgM secretion. Together these …
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MORPHOLOGICAL FEATURES OF THE REPRODUCTIVE ORGANS IN DOMESTIC SPECIES IN RELATION TO WATER MOVEMENT CONTROL, HYPONUTRITION AND ENVIRONMENTAL INFLUENCES IN FETAL AND PREPUBERTAL LIFE, AND METABOLISM REGULATOR FACTORS.
… showed a high expression of AQP1, AQP3, AQP4 and AQP9 respectively in blood vessels, smooth muscles, connective tissue and fat. As well known AQPs are ubiquitarly distributed in the body maintaining all the same the specific function as channels to permeate water and small solutes. I …