Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"AQP1"”.
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Pharmacological Modulation of Cancer Migration and Invasion Through Targeting AQP1 Ion and Water Channel Activity
… channel. Proposed aquaporin-1 blocker AqB050, AQP1 water channel blocker bacopaside II, and an aquaporin-1 ion channel blocker AqB011 were used. The circular wound closure assay is an innovative alternative approach for measuring cell migration and was introduced and utilised in this thesis. …
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AQP1—A REGULATORY FACTOR ASSOCIATED WITH BROWN ADIPOSE TISSUE SILENCING TO COMBAT OBESITY AND METABOLIC DISEASE
… a putative BAT-silencing factor, aquaporin-1 (AQP1), as a novel therapeutic target to protect subjects against DIO and metabolic dysfunction. Interrogation of in vivo metabolic parameters revealed BAT-specific AQP1 knockout mice (AQP1-KO) on high fat diet (HFD) experienced reduced diet-induced …
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Contribution of Causal Aquaporin-1 Mutations to the Pathobiology of Pulmonary Arterial Hypertension
… heterozygous variants in the Aquaporin-1 (AQP1) gene were identified among a small subgroup of PAH patients. AQP1 is a water channel protein critical for maintaining endothelial cell integrity and fluid homeostasis. The primary aim of this thesis is to provide insight into the potential …
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Imaging biological water permeability barriers using CARS microscopy
… in the water channel protein aquaporin 1 (AQP1) were examined to evaluate the role of AQP1 in vascular water permeability. A layered hydrogel imaging phantom was constructed from poly(ethylene glycol) diacrylate (PEGDA) to validate ability of water-CARS microscopy to determine the relative …
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Developing Novel Conservative Treatments For 2 Endometrial Cancer By Targeting Aquaporin-1
… endometrial cancer cells and identified a novel AQP1 ion channel inhibitor. We used Ishikawa and MFE-280 cell lines corresponding to low- and high-grade endometrial cancer cells and primary endometrial cancer cells derived from low- and high- grade cancer tissues. Chapter 3 of this thesis …
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The Convergence of Accelerated and Physiological Vascular Ageing: A Multi-Omic Analysis of 2D and 3D in vitro models of Progeria
… ageing models identified aquaporin 1 (AQP1) as a potential therapeutic target in the prevention and treatment of age-related vascular dysfunction. Here, we showed that AQP1 is upregulated in both accelerated and physiological ageing, and is differentially expressed in response to …
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Characterizing Changes in the Brain During Hydrocephalic Development and Exploring Potential Treatment Strategies
… also contain aquaporins (AQP), aquaporin-1 (AQP1) and aquaporin-4 (AQP4), important in regulating CSF and interstitial fluid (ISF). Increased fluorescent intensity of AQP4 in the subventricular zone and increased AQP1 apical localization and protein amount in the CP was observed in …
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CHARACTERIZATION AND FUNCTIONALITY OF RECOMBINANT AQUAPORINS FROM MOZAMBIQUE TILAPIA
… expressed nine tilapia aquaporins in yeast. As Aqp1 is found to have the highest water permeability function, it has proceeded on to be produced and purified in large scale and fermentation scale. This research will establish the basis and feasibility of Mozambique tilapia aquaporins for …
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Modeling and Simulating Biomolecular Machineries at Atomic Scale and Beyond
… (2) a membrane channel protein Aquaporin-1 (AQP1), conducting water through its individual monomeric pores, for which we have proposed a feasible mechanism of gating and ion conduction in its tetramerical central pore; (3) a four-way DNA junction (Holliday junction), a central intermediate in …
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Molecular Mechanisms of Gating, Selectivity, and Transport in Membrane Channels and Carriers
… to investigate the permeability of mammalian AQP1 and AQP4 to O2, CO2 and NO. Apart from water, these AQPs are found to provide pathways for gas molecules to cross biological membranes. Additionally, the phosphorylation-mediated gating of a plant aquaporin is investigated. Opening of the water …
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The mechanisms of aquaporin expression and translocation in cerebral pathologies
… non-sclerotic (TLE-NC) patient brain samples. AQP1 and AQP4 transcript expression was significantly increased, while AQP9 mRNA was significantly reduced in TLE-HS compared to TLE-NC. AQP4 protein expression was also increased while AQP1 protein remained unchanged and AQP9 was undetected. The …
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Deep forward and reverse phenotyping for genetic discovery in pulmonary arterial hypertension.
… COL6A5. While BMPR2, TBX4, EIF2AK4, ACVRL1 and AQP1 showed the highest association (PP≥0.99), I also confirmed significant associations in the majority of other previously identified genes. High impact variants in the KDR were associated with a significantly reduced KCO (KCO lower tertile, …
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MORPHOLOGICAL FEATURES OF THE REPRODUCTIVE ORGANS IN DOMESTIC SPECIES IN RELATION TO WATER MOVEMENT CONTROL, HYPONUTRITION AND ENVIRONMENTAL INFLUENCES IN FETAL AND PREPUBERTAL LIFE, AND METABOLISM REGULATOR FACTORS.
… lacking such channels. Based on studies with AQP1, it appears that AQPs exist in the plasma membrane as homotetramers. Each AQP monomer contains 2 hemi-pores, which fold together to form a water channel. Different aqps have different patterns of glycosylation. In the case of AQP1 the peptide …
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Sensing in biological systems
… These results suggest that the aquaporin-1 (AQP1) ion channel could be a novel candidate for therapeutic interventions to manage metastasis in AQP1-dependent cancers. Appendix B: The themes of tailored selectivity and signal enhancement developed in this thesis are further explored in …
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Pharmacologically impeding glioblastoma tumour motility through simultaneous inhibition of aquaporin-1 and ion channels
… described in this thesis identified sites within AQP1 where introduction or removal of histidine residues potentiated or abolished cGMPinduced ionic currents in the presence of Ni2+. Histidine could serve as a promising pH-sensing agent to be incorporated into the design of drug delivery systems …
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Preterm intraventricular haemorrhage - Effects of extracellular haemoglobin
… CSF production. Following IVH the expression of AQP1, the key AQP in the choroid plexus, is down-regulated whereas the expression of AQP5, not previously described in the choroid plexus, is up-regulated. This probably represents an adaptive response to insult and might be of importance in …
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Mechanism and energetics of membrane transporters and channels
… channels, urea transporter (UT) and aquaporin (Aqp1). Each simulations presented here provided a dynamical and atomistic picture of the protein of interest in a collaborative effort with an experimental lab. Membrane transporters use various source of cellular energy, e.g., ATP binding and …