Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"APP family"”.
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Characterization of APPBP2/PAT1a and Analysis of its interaction with APP family Proteins
… role of the Amyloid Precursor Protein (APP) and its homologues, Amyloid Precursor Protein like protein 1 and 2 (APLP1, APLP2), correlate strongly to their subcellular localization. Lines of evidences from Pimplikar and co-workers showed a kinesin light chain (KLC) like protein, termed …
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Studies of the cell biological function of the Amyloid Precursor Protein (APP) family in Drosophila melanogaster and mammals
… is derived from the Amyloid Precursor Protein (APP) by proteolytic processing. APP is a type I transmembrane protein, which resembles a cell surface receptor, and consists of a large ectodomain and a short cytoplasmic tail. While Abeta generation from APP is well investigated, the physiological …
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APP∙CNTN Complex Architecture is Conserved Throughout the Vertebrate Lineage
… molecules (CAMs) of the immunoglobulin (Ig) superfamily found throughout the metazoan lineage. CNTN architecture is broadly conserved, and these proteins are composed from the N-terminus of six Ig domains linked to four fibronectin type III (FN) domains. The C-terminal FN-4 domain terminates with …
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Expression and Transcriptional Regulation of APL-1, a <i>Caenorhabditis elegans</i> APP Ortholog
… drugs only slow its onset. AD shares many overlapping symptoms with other causes of dementia, but is characterized by certain molecular hallmarks, including the presence of neurofibrillary tangles and dense plaques, composed predominantly of Aβ peptide fragments. These fragments are cleavage …
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Defining the role of heparan sulfate proteoglycans in APL-1 function in Caenorhabditis elegans
… byproduct of the amyloid precursor protein (APP). APP family proteins are present in mammals and the family is considered necessary and essential for viability, although their exact function is still unclear. In <em>Caenorhabditis elegans</em> only one ortholog of <em>APP</em> is present, …