Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 2 of 2 for “"APOE4 gene"”.
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The role of complement FH and apoE interactions in the regulation of Aβ1-42 and C1q-mediated complement activation
The APOE4 gene variant of apolipoprotein E (apoE) has been identified as a predisposing factor for late-onset Alzheimer’s disease (AD). ApoE is known to interact with one of the classically characterized hallmarks of AD, the amyloid-beta (Aβ) protein. Aβ activates the classical complement pathway …
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Apolipoprotein E and propagation of pathological tau in Alzheimer’s Disease
… occurs alongside neuroinflammation and neurodegeneration. Clinically, AD is typified by cognitive decline. Pathological tau propagates through the AD brain in a defined manner, with indications this occurs trans-synaptically. Spread of pathological tau correlates with synapse loss and cognitive …