Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 153 for “"APOE"”.
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Influence of ApoE polymorphism on synaptic morphometry during aging in the dentate gyrus of ApoE knockout and human ApoE transgenic mice
Of the three forms of human Apolipoprotein E (ApoE2, ApoE3 and ApoE4), the ?4 allele coding for ApoE4 is associated with a higher risk of developing Alzheimer's disease (AD) and an earlier age of onset, whereas ?2 may be protective. The mechanisms underlying such influences are still unclear. This …
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ApoE Receptors in Alzheimer's and CNS Function
… for AD is the ε4 allele of apolipoprotein E (ApoE4). Other genes related to lipid metabolism and lipoprotein receptor signaling have also been identified as risk modifiers for AD. Despite nearly two decades of research, the mechanisms by which lipid transport proteins cause central nervous …
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ApoE, ApoER2, and the Regulation of Endothelial Cell Function
… in individuals with the apolipoprotein E (ApoE) allele ApoE4 versus ApoE3, and this is not explained by differences in lipid profiles. A point mutant of the ApoE receptor ApoER2, ApoER2-R952Q, is also associated with greater cardiovascular disease risk, suggesting a role for ApoER2 in …
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ApoE Risk Disclosure: A Review of Positive and Negative Outcome
<p>Two of this century’s most significant healthcare challenges are Alzheimer’s disease and mild cognitive impairment, with 40 million people suffering from the diseases. In fact, a conservative estimate projects that both conditions will double every 20 years until 2050. Alzheimer’s disease …
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In-vivo Metabolismus der VLDL-Apolipoproteine ApoB, ApoCIII und ApoE
… der VLDLApolipoproteine ApoB, ApoCIII und ApoE bei 6 normolipämischen und einem hypertriglyceridämischen Probanden mit einer endogenen nicht-radioaktiven Tracermethode. Als Tracer wurde mit D3 markiertes Leucin eingesetzt. Nach Abtrennung der verschiedenen Plasmalipoproteinklassen durch …
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MEMORY AND DEFAULT NETWORK ACTIVATION AS A FUNCTION OF APOE GENOTYPE
… of Episodic Memory as a function of the APOE genotype in a healthy young adult sample. To accomplish this, 98 subjects completed behavioral tasks assessing visual memory, working memory, episodic memory, and attention. Subjects also completed questionnaires evaluating IQ, years of …
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The relationship between Alzheimer's disease, inflammation, the APOE genotype and neuronal integrity
Includes abstract. Includes bibliographical references.
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Sledování exprese a koexprese endoglinu a P-selectinu v aortě apoE-deficientních myší
… a koexprese endoglinu a P-selektinu v aortapoE-deficientnch my Diplomovprce MonikaBrlicov Vedoucprce:Mgr.JanaRathousk Clprce: Sledovali jsme expresi a vzjemnou koexpresi endoglinu (receptoru III pro TGF- cytokin) a P-selektinu (adhezn molekuly a markeru endoteliln …
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The APOE Pathway as a Modulator of Amyloid Pathology in Alzheimer's Disease Models
… amyloid plaque deposition. The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for sporadic AD, with apoE protein crucial for brain lipid transport. ATP-binding cassette subfamily A member 1 (ABCA1), another risk gene, loads lipids onto apoE, highlighting the importance of …
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AB affects apoE transcriptionally through the activation of B-AR, cAMP and AP-2
… amyloid beta protein (Aβ) and apolipoprotein E (apoE). We and others have reported that Aβ elevates apoE protein levels in astrocytes, which in turn could alter lipid trafficking and cell function. The mechanism for the Aβ-induced increase in apoE levels is not clearly understood. We propose that …
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Identification of a MicroRNA Network that Regulates Melanoma Metastasis and Angiogenesis by Targeting ApoE
… and the metabolic protein apolipoprotein E (ApoE). Interestingly, this work also revealed that DNAJA4 positively regulated ApoE expression, establishing ApoE as the central molecule in this convergent network. Consistent with these findings, treatment of multiple melanoma lines with ApoE …
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Genetic approaches to studying coronary heart disease in SR-BI/apoE double knockout mice
… buildup of fatty deposits in vessel walls. SR-BI/apoE double knockout (dKO) mice are a novel mouse model of human CHD, exhibiting spontaneous coronary occlusive atherosclerosis, myocardial infarction, cardiac dysfunction and premature death. This model represents a unique system in which to study …
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Investigating the effects of TREM2, APOE and PILRα variants on microglial functions and neuronal loss
… roles of AD-risk associated variants of TREM2, APOE and PILRα in microglial functions and neuronal loss. Triggering receptor on myeloid cells 2 (TREM2) is an innate immune receptor, primarily expressed by microglia in the CNS and upregulated on the surface of microglia associated with amyloid …
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