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Showing 1 to 11 of 11 for “"APOBEC3 proteins"”.
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The Dynamic Interplay Between Lentiviral Vif and Human APOBEC3 Proteins
Four members of the APOBEC3 (A3) family of DNA cytosine deaminases are capable of inhibiting HIV-1 replication by deaminating viral cDNA cytosines and interfering with reverse transcription. HIV-1 counteracts restriction with its Vif protein, which nucleates a ubiquitin ligase complex that directly …
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Regulation of APOBEC3 activity and HIV-1 replication by P-body associated proteins
… regarding the anti-viral nature of these proteins, their cellular function, as well as mechanisms of functional regulation and cellular co-factors, remains poorly defined. To address this, several cellular proteins that interact with APOBEC3G (A3G) have now been identified. The most …
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Regulation of exogenous retroviruses and endogenous retroelements by MOV10
… Identification of the full complement of these proteins is vital to comprehend the capacity of the host to regulate these genetic parasites. Human MOV10 is a putative RNA helicase with inhibitory or stimulatory roles in the replication of several RNA viruses, and the homologs of which play vital …
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Development of biophysical and Mass Spectrometry Assays for APOBEC3 cytosine deaminases: discovery and validation of cnvalent and non-covalent ligands
APOBEC3 enzymes are cytosine deaminase enzymes that catalyze the conversion of a cytosine base to uracil in single-stranded DNA. There are seven members of the APOBEC3 family – A3A/B/C/DE/F/G/H. APOBEC3 proteins are a part of the innate immune defense system against viral infection, and mutate the …
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The Impact of Host Factors on Retroviral Evolution and the Identification of a Novel Receptor That Was Used by an Ancient Primate Retrovirus
… and chimpanzees. It is possible that antiviral proteins were able to protect human ancestors from colonization by CERV1 and CERV2. Indeed, sequence analyses of modern primate restriction factors has suggested that these genes have evolved under positive selection, presumably due to their combat …
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Interactions Between APOBEC3 and Murine Retroviruses: Mechanisms of Restriction and Drug Resistance
APOBEC3 proteins are important for antiretroviral defense in mammals. The activity of these factors has been well characterized in vitro, identifying cytidine deamination as an active source of viral restriction leading to hypermutation of viral DNA synthesized during reverse transcription. These …
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INTERACTIONS BETWEEN THE GLYCOSYLATED GAG PROTEIN OF A MURINE LEUKEMIA VIRUS AND MURINE APOBEC3: NOVEL INSIGHTS INTO HOW A MURINE LEUKEMIA VIRUS COUNTERACTS A RESTRICTION FACTOR
<p>APOBEC proteins have evolved in mice and humans as potent innate defences against retroviral infections. APOBEC3G (hA3G) in humans and mouse APOBEC3 (mA3) deaminate cytidine in single-stranded DNA which ultimately results in hypermutation of newly synthesized proviral DNA. Other …
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INTERACTIONS BETWEEN THE GLYCOSYLATED GAG PROTEIN OF A MURINE LEUKEMIA VIRUS AND MURINE APOBEC3: NOVEL INSIGHTS INTO HOW A MURINE LEUKEMIA VIRUS COUNTERACTS A RESTRICTION FACTOR
<p>APOBEC proteins have evolved in mice and humans as potent innate defences against retroviral infections. APOBEC3G (hA3G) in humans and mouse APOBEC3 (mA3) deaminate cytidine in single-stranded DNA which ultimately results in hypermutation of newly synthesized proviral DNA. Other …
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Restriction of Retrotransposition and Retroviral Infection by RNase L and APOBEC3G
… expression of both L1 open reading frame proteins and formation of LINE-1 ribonucleoprotein particles. By controlling dysregulated LINE-1 retrotransposition, RNase L could contribute to the maintenance of genomic stability and fulfill its tumor suppressor function. The interaction between …
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Paleovirological Analyses of Endogenous Retroviruses and Host Innate Immune Effectors
… we found that the expression of mouse APOBEC3 was able to restrict the replication of ancML. However, inspection of endogenous MuERV-L sequences suggested that the impact of APOBEC3 mediated hypermutation on MuERV-L evolution was limited. We discussed the possibility that type I IFN …
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Diversity in APOBEC3 and CCR5 host genes and HIV-1 in a South African population
… activities of host restriction factors such as APOBEC3G protein, which is a member of the DNA cytosine deaminase family. Entry of HIV in to the host cell is through the attachment of the viral envelope glycoprotein to the CD4 receptor, and subsequent interaction, mainly with either CCR5 or CXCR4 …