Global ETD Search
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Showing 1 to 3 of 3 for “"APOBEC1 proteins"”.
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Apobec1-Mediated RNA Editing in Monocytes Contributes to Genetic Heterogeneity and Modulates Monocyte Activity and Development
… these modifications. In this thesis, I focus on APOBEC1-mediated RNA editing. In higher eukaryotes RNA editing consists of C to U and A to I transitions mediated by the proteins of the APOBEC1 and ADAR families, respectively. APOBEC1 has been fully characterized in its role of editing the …
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Transcriptome-Wide Characterization of APOBEC1-Catalyzed RNA Editing Events in Macrophages
… B mRNA Editing Catalytic polypeptide-1 (APOBEC1). The ADARs and APOBEC1 were originally characterized as catalysts for previously characterized biologically important RNA-editing events that resulted in specific coding changes; study of additional editing activity was limited by standard …
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Identification and Characterization of APOBEC1 mRNA Editing Targets: A Transcriptomics Approach
… B mRNA Editing Catalytic polypeptide 1 (APOBEC1) cytidine deaminase is an mRNA editing enzyme that modifies a specific cytidine in the apolipoprotein B (apoB) transcripts of small intestine enterocytes. APOBEC1-mediated cytidine to uridine editing generates an inframe stop codon and …