Global ETD Search
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Showing 1 to 3 of 3 for “"APL-1"”.
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Expression and Transcriptional Regulation of APL-1, a <i>Caenorhabditis elegans</i> APP Ortholog
… a member of the APP family which also includes APLP1 and APLP2. In mammals, these proteins share overlapping expression patterns and functions, making experiments difficult to perform and interpret. The nematode <em>Caenorhabditis elegans</em>, however, has only one APP family member: APL-1, an …
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Defining the role of heparan sulfate proteoglycans in APL-1 function in Caenorhabditis elegans
… one ortholog of <em>APP</em> is present, <em>apl-1</em>. Similar to <em>APP</em> family members, <em>apl-1</em> is essential for viability; APL-1 is cleaved and releases an extracellular fragment, sAPL-1, into the extracellular matrix (ECM). Based on previous research in the lab, sAPL-1 likely …
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Role of MOA-1, an Anti-phosphatase, and APL-1, an APP-related Protein, in Morphogenesis and Mating Behavior in Caenorhabditis elegans
… disease. Due to the presence of two paralogues, APLP1 and APLP2, which have overlapping functions, the normal function of APP is difficult to elucidate. Knockout of the entire APP gene family in mice results in lethality and developmental defects, indicating that the APP gene family has an …