Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"APL"”.
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Role of Abberant Proteolysis in the Pathogenesis of APL
Acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML), is caused by PML-RARN1, a fusion protein resulting from chromosomal translocation involving the promyelocytic leukemia (PML) and the retinoic acid receptor N1 (RARN1) genes. PML-RARN1 promotes misfolding of nuclear …
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A user guide to interactive APL/360 programs for operations research
Digitized by Kansas Correctional Industries
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A user guide to interactive APL/360 programs for operations research
Digitized by Kansas Correctional Industries
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Adapted Primary Literature (APL): An Effective Authentic Text Option for the Science Classroom
… the incorporation of Adapted Primary Literature (APL) into secondary science classroom instruction in order to aid such science curriculum in achieving balanced authenticity. APL is a valuable instructional text option due to its novel design, an optimal compromise between authenticity and …
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Expression and Transcriptional Regulation of APL-1, a <i>Caenorhabditis elegans</i> APP Ortholog
… a member of the APP family which also includes APLP1 and APLP2. In mammals, these proteins share overlapping expression patterns and functions, making experiments difficult to perform and interpret. The nematode <em>Caenorhabditis elegans</em>, however, has only one APP family member: APL-1, an …
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Defining the role of heparan sulfate proteoglycans in APL-1 function in Caenorhabditis elegans
… one ortholog of <em>APP</em> is present, <em>apl-1</em>. Similar to <em>APP</em> family members, <em>apl-1</em> is essential for viability; APL-1 is cleaved and releases an extracellular fragment, sAPL-1, into the extracellular matrix (ECM). Based on previous research in the lab, sAPL-1 likely …
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Dissecting the Molecular Basis of the Antiphospholipid Syndrome
… by circulating antiphospholipid antibodies (aPL), thrombotic events, recurrent pregnancy loss, and increased risk of coronary artery disease. The endothelium is a critical direct target of aPL, which cause increases in adhesion molecule expression and procoagulant activity. However, the …
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The Role of Notch Signaling in the Pathogenesis of Acute Promyelocytic Leukemia
… in nearly 98% of acute promyelocytic leukemia: APL, FAB subtype M3) cases and results in the fusion of the promyelocytic leukemia: PML) gene with the retinoic acid receptor alpha: RARA) gene. The fusion product, PML-RARA, encodes a functionally altered transcription factor that is the initiating …
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Role of MOA-1, an Anti-phosphatase, and APL-1, an APP-related Protein, in Morphogenesis and Mating Behavior in Caenorhabditis elegans
… disease. Due to the presence of two paralogues, APLP1 and APLP2, which have overlapping functions, the normal function of APP is difficult to elucidate. Knockout of the entire APP gene family in mice results in lethality and developmental defects, indicating that the APP gene family has an …
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Evaluation of Internal Markers for Predicting Digestibility and Fecal Output by Cattle Fed Bermudagrass Hays of Varying Quality
… insoluble ash (ADIA), alkaline-peroxide lignin (APL), and acid-detergent lignin (ADL) to predict digestibility (DMD) and fecal output (FO) by cattle fed bermudagrass <em>[Cynodon dactylon </em> (L.) Pers.] hay-diets categorized by their low (L), medium low (ML), medium high (MH), or high (H) CP …
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ROLE OF THE HISTONE DEMETHYLASE LSD1 IN THE REGULATION OF DIFFERENTIATION OF ACUTE PROMYELOCYTIC LEUKEMIA CELLS
Acute promyelocytic leukemia (APL) is characterized by the appearance of blasts, insensitive to physiological retinoic acid (RA)-dependent differentiation and in the majority of the cases, expressing PML-RAR fusion protein. PML-RAR works as a dominant negative counterpart of retinoic acid receptor …
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Rational Agents: Prioritized Goals, Goal Dynamics, and Agent Programming Languages with Declarative Goals
… a Simple Rational Agent Programming Language (SR-APL) with declarative goals. SR-APL is based on the ``committed agent'' variant of this rich theory, and combines elements from Belief-Desire-Intention (BDI) APLs and the situation calculus based ConGolog APL. Thus SR-APL supports prioritized goals …
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Regulation of NF-κB by PML and PML-RARα
… are causative for acute promyelocytic leukemia (APL). We demonstrate that sumoylation of PML and PML NBs isinvovled in NF-κB- induced transcriptional responses and is required for phosphorylation of NF-κB p65. This is the first study to separate the function of diffused PML and PML NBs. …
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Design and Development of Advanced Adaptive Polymer Lenses
… the allowable fabrication variables, first for APL singlets and then for APL doublets. A first-order finite element model is described that enables going from an optical design to APL fabrication. This model was then extended to the design of fluidic doublets, which are equivalent to their …
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Southern Irish Unionism during the revolutionary and post-Independence periods, 1912-1932
… Midleton in the Unionist Anti-Partition League (APL), and this research takes advantage of the previously unexamined Anti-Partition League Papers which are held in PRONI.The thesis will argue that commercial interests became increasingly powerful within the Irish Unionist Association (IUA), …
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Incorporating passive solar issues in design methodology
… notations -- english, math and Iverson notation (APL). English and math were used in the text of the thesis to communicate theory to the reader. Two APL workspaces, "THERM" and "THERM2," were created to communicate with a computer; and hence, enable the application of the methodological structure …
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Evaluation of the role of autophagy in acute myeloid leukaemic cell differentiation
… the treatment of acute promyelocytic leukaemia (APL). The differentiation of APL cells treated with ATRA in vitro is a model that allows the examination of differentiation pathways in myeloid leukaemic cells. Using this principle, my thesis examines the activity during differentiation, of two …
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EXPLORING THE PRE-LEUKEMIC PHASE OF ACUTE PROMYELOCYTIC LEUKEMIA: INSIGHTS FROM STUDIES OF SINGLE CELL ¿OMICS¿
Acute Promyelocytic Leukemia (APL) is a distinct subtype of Acute Myeloid Leukemia (AML) driven by the oncogenic fusion protein PML-RAR, which acts as an aberrant transcription factor and blocks myeloid maturation at the promyelocyte stage. In vivo, the expression of PML-RAR is necessary but not …
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