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Showing 1 to 13 of 13 for “"APCmin"”.
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Effects of sucrose, glucose, and fructose consumption on intestinal tumorigenesis in APCMin mice
… study is to determine the effects of feeding APCMin as well as normal C57BL6/J mice diets containing corn starch (control), sucrose, glucose, fructose, or a 1:1 ratio of glucose:fructose (G:F) as the sole carbohydrate source. The G:F treatment is meant to mimic the composition of high fructose …
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Data Management tools For Metagenomic Datasets, A Case Study: Characterization and Dysbiosis of Gut Microbiota In Apcmin/+ Mice With and Without Colon Tumors
… isolated from colon tissue and stool samples of APCmin/+ mice (a mouse model of colon cancer). A total of 171,405 unprocessed sequences were generated from proximal and distal colon sections as well as stool samples using 454-pyrosequencing. The preprocessing step resulted in 72% of high-quality …
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The Effect of Sex and Exercise Training During the Progression of Cancer Cachexia In the Apc Min/+ Mouse
… related to the development of cachexia. ApcMin/+ mouse is as an animal model of colorectal cancer that has been widely used to study intestinal and colon polyp formation and growth, the effect of exercise and nutritional intervention as well as the regulation and progression of cancer …
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The Complex Interactions between Genetics and Environment: Diet, Inflammation and Intestinal Tumorigenesis
… omega-6 polyunsaturated fatty acids. Using the ApcMin/+ model of intestinal neoplasia and diets constructed from 58% coconut, corn or olive oils, we demonstrate that high amounts of dietary fats can have differential effects on DIO and MetS, as well as on intestinal tumorigenesis when compared …
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Skeletal Muscle Protein Turnover During Cancer Cachexia In the Apc<sup>min/+</sup> Mouse
… protein turnover. Our laboratory has shown the ApcMin/+ mouse, a model of colorectal cancer is an excellent model to study the progression of cachexia due to the gradual decline in body weight and dependency on circulating IL-6 levels, as seen in human cachexia. The primary purpose of this study …
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The role of CysLT1R in animal models of colorectal cancer
… in 1) FAP/sporadic colorectal cancer by crossing ApcMin/+ mice with mice lacking CysLT1R expression and in 2) colitis-associated colorectal cancer by employing the AOM/DSS-model on mice lacking CysLT1R expression. Interestingly, a reduced polyp formation in a gender-specific manner could be …
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Microultrasound Imaging of Tissue Dysplasia
… tissue morphology of WT (wild type) and ApcMin/+ (adenomatous polyposis coli) diverges with progressing age intervals (60, 90 and 120 days) of mice. A high frequency ultrasound scanning system was designed and the experiments were performed ex vivo using a focused 45 MHz, f-# = 2.85, µUS …
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Mouse modifiers of intestinal tumorigenesis
… IV cytosolic phospholipase a2 (cPLA2). Crossing ApcMin into this background produces an 83% reduction in tumor number in ApcMin, cPLA2 -/- homozygotes, suggesting that cPLA2 expression promotes tumorigenesis, most likely via the production of arachidonic acid for downstream eicosanoid synthesis.
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Linking Inflammation to Tumorigenesis In A Mouse Model of High-Fat Diet-Enhanced Colon Cancer: Does Fat Type Matter?
… in relation to colon cancer progression in ApcMin/+ mice. Male ApcMin/+ mice (7-8/group) were assigned to one of four treatment groups as follows: 1) AIN-76A (5% fat) Control (Con), 2) Higher Saturated Fat Diet (24% saturated & 16% unsaturated) (HFD-24%), 3) American Standard Diet (12% …
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The microbiota and colon cancer risk: cause or consequence?
Background: Colorectal cancer (CRC) has a complex aetiology involving both genetic and environmental factors. Recently, attention has turned to the influence of the gut microbiota upon the development of CRC. The human gut microbiota is altered in CRC and certain microbial patterns are associated …
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MiRNA-Mediated Regulation of Colorectal Tumorigenesis
… tract. Consistent treatment with AMO-miR-16 in ApcMin/+ mice is efficacious in promoting increased tumorigenesis within the small intestine and colon, and is associated with dysregulation of miR-16 target genes and associated pathological response.</p> <p>Elevated levels of PGE2 observed in …