Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 3 of 3 for “"APC3"”.
-
Strengths and Weaknesses of Hybrid TPR Technology for Obtaining Structural and Mechanistic Insights into TPR Proteins
… of four related TPR proteins, APC8, APC6, APC3, and APC7, with each found in pairs. Crystal structures of some of these indicate that each has an N-terminal dimerization domain and a C-terminal domain that APC3 extends away from the dimer interface. The TPR C-terminal domains are thought to …
-
Functional characterisation of the human mitochondrial ATP-Mg/Pi carriers and their disease-causing variants
… four different human APC paralogues: APC1, APC2, APC3 and APC4, some of which have multiple splice variants. Recently, disease variants in APC1 and APC3b have been identified in patients with severe developmental disease or with kidney dysfunction, respectively. The biochemical properties of human …
-
Mechanism of APC/C activation and substrate specificity in mitosis
… Cdk-cyclin-Cks to a hyper-phosphorylated loop of Apc3. In addition to regulation of APC/C activity by phosphorylation, ordered cell progression is ensured by the ability of the APC/C to target substrate degradation in a defined order. At mitosis onset, degradation of securin and cyclin B1 is …