Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"APC mutation"”.
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Communication In Family Members With A Rare APC Mutation
<p>OBJECTIVES: APC-associated polyposis is caused by mutations in the APC gene and includes familial adenomatous polyposis (FAP), an autosomal dominant cancer predisposition syndrome which has a lifetime risk of colon cancer of almost 100%. Identifying a genetic mutation can provide important …
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Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
… majority of which are driven by loss-of-function mutations in the Adenomatous Polyposis Coli (APC) tumour suppressor gene, and are largely refractory to current cancer immunotherapies. As presented in this thesis, examination of cancer gene expression profiles from CRC patients in large, publicly …
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The mechanism of HAMLET-induced cell death - cellular signalling, oncogenes and clinical perspectives
… as well as mortality in mice carrying a human APC mutation. In tumours surviving HAMLET challenge a reduction in onco-protein expression was detected as well as an increase in expression of glycolic enzymes. By long-term prophylaxis, prevention of tumour development was achieved.
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Multi-omic characterisation of Barrett’s oesophagus reveals a molecular continuum in the progression to oesophageal adenocarcinoma
… BE is highly heterogeneous with regards to mutational load, copy-number aberrations (CNAs) and structural variants (SVs). Mutational signatures are laid down early and persist regardless of progression status. Hence, Cosmic signature 17 (T:A>G:C in a CTT context), the hallmark of OAC, is …
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Regulation of MINK1 by APC, PKA and MARK3/4 and consequences for epithelial cell biology
… suppressor gene adenomatous polyposis coli (APC) is mutated. The APC protein is closely linked to epithelial tissue homeostasis, it is a scaffolding protein in Wnt signalling and is important for cytoskeletal regulation. Misshapen/NIK-related kinase 1 (MINK1) was identified as a Wnt …
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Assessing Parental Attitudes Towards Hepatoblatosma Screening
<p>OBJECTIVES: Familial adenomatous polyposis (FAP) is an autosomal dominant cancer predisposition syndrome with nearly a 100% lifetime risk of developing colorectal cancer, if left untreated. Children with FAP have up to a 2% risk for the development of hepatoblastoma (HB). Guidelines for HB …