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Showing 1 to 20 of 32 for “"APC/C"”.

  1. Identification and functional characterisation of novel APC/C interacting proteins

    Sedgwick, Garry GrayUniversity of Birmingham2010

    The anaphase promoting complex /cyclosome (APC/C) is a multi-protein E3 ubiquitin ligase complex that regulates cellular proliferation through its ability to target essential cell cycle regulators such as cyclin A, cyclin B, securin and S-phase kinase-associated protein 2 (SKP2) for …

    birmingham Repository record

  2. Mechanism of APC/C activation and substrate specificity in mitosis

    Zhang, SuyangUniversity of Cambridge2018

    … by the anaphase-promoting complex/cyclosome (APC/C). The APC/C is an E3 ubiquitin ligase that regulates chromatid segregation at the metaphase to anaphase transition, exit from mitosis and the establishment and maintenance of G1. The APC/C’s catalytic activity and substrate specificity are …

    cambridge Repository record

  3. Characterisation of the KA1 & KA2 domains and interaction with APC/C

    Medina, Bethan AnnThe University of Edinburgh2011

    … is the anaphase promoting complex/cyclosome (APC/C) which is responsible for faithful segregation of chromosome during mitosis. Failure to regulate this process can lead to aneuploidy, one of the main causes of cancer. It is therefore important to understand the function and regulation of …

    edinburgh Repository record

  4. Ciclo celular y neurodegeneración: implicación de la E3 ubitiquina ligasa APC/C-Cdh1en la excitotoxicidad

    Maestre Ferrín, Carolina2009

    salamanca Repository record

  5. La activación de la E3 Ubiquitina ligasa APC/C-Cdh1 es esencial para la supervivencia neuronal. Desarrollo de un modelo murino de neurodegeneración in vivo

    Bobo-Jiménez, Verónica2014

    salamanca Repository record

  6. Understanding Structural And Functional Mechanisms of Emi1 Inhibition of the Anaphase Promoting Complex

    Watson, Edmond Randall2018

    … Promoting Complex, also called Cyclosome (APC/C), modifies myriad substrates that control cell cycle activities. The APC/C is a ubiquitin ligase complex; it is the final enzyme in a tri-enzyme cascade and catalyzes the final step of Ub transfer from an E2 enzyme directly to substrates. A …

    tenn-hsc Repository record

  7. Regulation of Anaphase Promoting Complex/Cyclosome to Control M Phase Exit

    Tang, Wanli2010

    <p>The Anaphase Promoting Complex/Cyclosome (APC/C) is a RING E3 ligase that plays essential roles both within and outside of the cell cycle. At the onset of anaphase, the APC/C targets cyclin B and securin for degradation, initiating chromosome separation and mitotic exit. Regulation of APC/C …

    duke Repository record

  8. Meiosis-specific Regulation of the Anaphase-Promoting Complex

    Oelschlägel, TobiasTechnische Universität Dresden

    … the Anaphase-Promoting Complex or Cyclosome (APC/C). APC/C-dependent destruction of securin/Pds1 is required to activate separase, a thiol protease that mediates chromosome segregation by cleavage of the cohesin complex. The first meiotic division is preceded by an extended prophase I, during …

    qucosa-diss

  9. Protein Modification and Degradation in the Cell Cycle of the Yeast Saccharomyces cerevisiae

    Dieckhoff, Patrick2012

    … Anaphase-promoting complex , auch Cyclosom oder APC/C genannt, ist eine große Ubiquitin-Ligase, die sowohl im meiotischen als auch im mitotischen Zellzyklus benötigt wird. Ihre Aufgabe ist das Anbringen von Ketten des Proteins Ubiquitin, welches die Proteolyse am 26S-Proteasom auslöst. Die …

    goettingen Repository record

  10. Harnessing the Anaphase-Promoting Complex for Targeted Protein Degradation

    Okoye, Cynthia NgoziUniversity of Cambridge2022

    … the anaphase-promoting complex or cyclosome (APC/C). The APC/C is a vital ubiquitin ligase involved in the destruction of numerous proteins including Securin, Cyclin B1 and Aurora kinase A. Most natural APC/C substrates contain multiple copies of short linear motifs (SLiMs), termed degrons, …

    cambridge Repository record

  11. A meiosis-specific form of the Anaphase Promoting Complex/Cyclosome regulates the oocyte-to-embryo transition in Drosophila

    Whitfield, Zachary JamesMassachusetts Institute of Technology2013

    … is the Anaphase Promoting Complex/Cyclosome (APC/C), an E3 ubiquitin ligase. The APC/C targets its substrates for degradation, and thus progresses the cell cycle irreversibly forward. Many substrates of the APC/C have been identified in mitosis, but how the APC/C regulates meiosis is less well …

    mit Repository record

  12. Enhanced protein degradation by branched ubiquitin chains

    Meyer, Hermann-JosefUniversität Bayreuth

    … are unknown. The anaphase-promoting complex (APC/C) catalyzes degradation of key regulators during the cell cycle causing proper transition through the cell cycle. Here, I report that the APC/C efficiently synthesizes substrate-attached branched conjugates and enhances recognition of …

    bayreuth Repository record

  13. Molecular Mechanisms Involved in Chromosome Segregation

    Yatskevich, StanislauUniversity of Cambridge2022

    … The anaphase promoting complex/cyclosome (APC/C) is a key regulator of the anaphase transition, and SAC directly inhibits APC/C via a soluble mitotic checkpoint complex (MCC). While many molecular details of APC/C function are now known, recent data suggest that the APC/C is also SUMOylated …

    cambridge Repository record

  14. The developmental role and regulation of the Anaphase-Promoting Complex/Cyclosome in Drosophila meiosis

    Pesin, Jillian Annice (Pesin-Fulop)Massachusetts Institute of Technology2008

    … by the Anaphase-Promoting Complex/ Cyclosome (APC/C). During oogenesis of multicellular organisms, molecular control of meiosis has an added complexity because these divisions must be coordinated with the growth and development of the oocyte as well as its fertilization. The Drosophila gene …

    mit Repository record

  15. Development of peptide inhibitors as molecular therapeutics against tandem-repeat proteins

    Eapen, RohanUniversity of Cambridge2019

    … (TNKS) the Anaphase Promoting Complex/Cyclosome (APC/C-Cdc20). TNKS belong to the poly-ADP-ribose polymerases (PARP) family of enzymes that PARylate their substrates, leading to ubiquitination and subsequent degradation. TNKS bind their protein substrates through an ankyrin-repeat domain …

    cambridge Repository record

  16. Mitotic regulators and their effects on Drosophila : chromosome structure during development

    Wallace, Julie Ann, 1977-Massachusetts Institute of Technology2005

    … of cyclin B, a known mitotic target of the APC/C, does not alter the timing of the transition, indicating that CYCLIN B is not the only APC/C target at the polyteny-polyploidy transition. In mitosis, activity of APC/C and POLO lead to the loss of sister-chromatid cohesion and we find that …

    mit Repository record

  17. Molecular Mechanisms of Mitotic Checkpoint Complex Assembly onto Kinetochores

    Fischer, ElyseUniversity of Cambridge2022

    … the anaphase-promoting complex/cyclosome (APC/C). Inhibition of the APC/C then delays premature chromosome segregation by preventing APC/C-mediated degradation of two key cell cycle regulators, cyclin B and securin. The MCC is composed of BubR1, Cdc20 and Mad2, and while their assembly is …

    cambridge Repository record

  18. TRAF Regulation of Caspase-2-Dependent Apoptosis in Response to DNA Damage

    Robeson, Alexander2016

    … (MCC), inhibits the anaphase-promoting complex (APC/C) by binding to the APC/C co-activator, CDC20. This prevents the APC/C from targeting critical pro-mitotic proteins, like cyclin B and securin, to promote mitotic exit. Although the function of the MCC is well understood, its regulation is not, …

    duke Repository record

  19. The peptidyl-prolyl isomerase Pin1 is required for maintenance of the spindle assembly checkpoint

    Brown, AndreasUniversität Bayreuth

    … by the anaphase promoting complex or cyclosome (APC/C), a multisubunit ubiquitin ligase, in conjunction with its essential co-activator Cdc20. The spindle assembly checkpoint (SAC) is a surveillance mechanism that monitors the chromosomes' interactions with the microtubules of the mitotic spindle …

    bayreuth Repository record

  20. The Multifunctional Kinase Bub1 Acts as a Signaling Hub for the Spindle Checkpoint

    Jia, Luying2018

    … ligase, anaphase-promoting complex or cyclosome (APC/C). Cdc20 is the mitosis-specific APC/C activator. The spindle checkpoint prevents premature sister chromatids separation by preventing Cdc20 from activating APC/C. Bub1 is a highly conserved spindle checkpoint protein that plays multiple roles …

    utswmed Repository record

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