Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 268 for “"APC"”.
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The Non-Wnt Functions of APC: Unravelling the Link between APC and Apoptosis
… suppressor gene Adenomatous polyposis coli (<i>Apc</i>). The most commonly studied function of APC is its role as a scaffold for the β-catenin destruction complex involved in Wnt signalling. However, APC binds many other proteins. For example, it directly binds to and stabilises microtubules and …
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Tumour suppression mediated through DPC4, p53 and APC
… (or DPC4, deleted in pancreatic cancer locus 4), APC (adenomatous polyposis coli) and p53 have been implicated in pancreatic cancer in humans. This thesis firstly documents the in vivo effects of mutations in these genes singly and in combination through spontaneous and carcinogen- induced murine …
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Synthetic Essentiality of Tdo2 In Apc-Mutated Colorectal Cancer
… of the adenomatous polyposis coli (APC) tumor suppressor is</p> <p>common genetic event across many cancers and serves a critical initiating</p> <p>event in the majority of sporadic colorectal cancers (CRC). The WNT/APC</p> <p>pathway remains an elusive target for cancer, prompting …
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Communication In Family Members With A Rare APC Mutation
<p>OBJECTIVES: APC-associated polyposis is caused by mutations in the APC gene and includes familial adenomatous polyposis (FAP), an autosomal dominant cancer predisposition syndrome which has a lifetime risk of colon cancer of almost 100%. Identifying a genetic mutation can provide important …
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INSIGHTS INTO SUBSTRATE RECOGNITION BY THE ANAPHASE PROMOTING COMPLEX (APC)
… ligase called the anaphase promoting complex (APC). APC adds polyubiquitin chains to numerous substrates, which leads to their subsequent degradation in late mitosis and G1 phase. The selective and timely recognition and degradation of APC substrates is essential for proper cell cycle …
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Identification and functional characterisation of novel APC/C interacting proteins
The anaphase promoting complex /cyclosome (APC/C) is a multi-protein E3 ubiquitin ligase complex that regulates cellular proliferation through its ability to target essential cell cycle regulators such as cyclin A, cyclin B, securin and S-phase kinase-associated protein 2 (SKP2) for …
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Mechanism of APC/C activation and substrate specificity in mitosis
… by the anaphase-promoting complex/cyclosome (APC/C). The APC/C is an E3 ubiquitin ligase that regulates chromatid segregation at the metaphase to anaphase transition, exit from mitosis and the establishment and maintenance of G1. The APC/C’s catalytic activity and substrate specificity are …
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Characterisation of the KA1 & KA2 domains and interaction with APC/C
… is the anaphase promoting complex/cyclosome (APC/C) which is responsible for faithful segregation of chromosome during mitosis. Failure to regulate this process can lead to aneuploidy, one of the main causes of cancer. It is therefore important to understand the function and regulation of …
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Understanding bus service reliability : a practical framework using AVL/APC data
… Location (AVL) and Automatic Passenger Counters (APC) provides the opportunity to gather large sets of data at relatively low cost and evaluate service to improve performance, schedule planning and operations control. This thesis presents a comprehensive review of key elements of service …
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The role of APC in cellular and tissue organisation in intestinal tumorigenesis
The tumour suppressor adenomatous polyposis coli (APC) is a multifunctional protein regulating a diverse array of effector pathways essential for cellular homeostasis. In most sporadic colon cancers, truncating mutations in APC lead to the loss of the Wnt pathway and microtubule regulatory domains. …
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Arenaviruses: the Role of Antigen Presenting Cells (APC) in Persistence and Immunopathology
… of cells called the antigen presenting cells (APC). APC play a significant role in immune response, as the receptionist, they are the first cells to detect pathogen invasion and present the antigen to the cells of the adaptive immune system for activation and clearance of the pathogen. This …
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Tumor Suppressor APC and Musashi1: Double-Negative Feedback, Wnt Signaling and Colon Cancer
… a mutation in the Adenomatous polyposis coli (APC) tumor suppressor gene. We study the intracellular functions of normal APC and how loss of APC function leads to the formation of precancerous polyps in the intestines of mice and humans. The studies presented here are particularly concerned …
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Skeletal Muscle Protein Turnover During Cancer Cachexia In the Apc<sup>min/+</sup> Mouse
… protein turnover. Our laboratory has shown the ApcMin/+ mouse, a model of colorectal cancer is an excellent model to study the progression of cachexia due to the gradual decline in body weight and dependency on circulating IL-6 levels, as seen in human cachexia. The primary purpose of this study …
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Enhancement Of Magnetic Vortex Pinning by APCs with Coherent BZO 1D-APC/YBCO Interface
… by inserting artificial pinning centers (APCs) in high temperature superconductors (HTS) such as YBa2Cu3O7-x (YBCO). Unfortunately, a degraded APC/YBCO interface can limit the pinning force making high field/high Jc applications unfeasible. The effect of APC/YBCO interface on pinning is …
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Regulation of MINK1 by APC, PKA and MARK3/4 and consequences for epithelial cell biology
… suppressor gene adenomatous polyposis coli (APC) is mutated. The APC protein is closely linked to epithelial tissue homeostasis, it is a scaffolding protein in Wnt signalling and is important for cytoskeletal regulation. Misshapen/NIK-related kinase 1 (MINK1) was identified as a Wnt …
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Investigating the roles of IL-25, IL-33 and ILC2s in APC-mutation-mediated colorectal cancer
… mutations in the Adenomatous Polyposis Coli (APC) tumour suppressor gene, and are largely refractory to current cancer immunotherapies. As presented in this thesis, examination of cancer gene expression profiles from CRC patients in large, publicly available online databases indicated that …
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Employing T Cells For Antigen Presentation: Role of Ny-Eso-1+ T-Apc Vaccine In Multiple Myeloma
… T cells (TCR mimetic) and an NY-ESO-1 specific T-APC vaccine in myeloma patients may lead to enhanced anti-myeloma efficacy due to improved persistence of the CAR T cells.</p> <p><strong>Materials and Methods</strong>: Using the Sleeping Beauty transposon/transposase system, an …
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Investigating the functional significance of the upregulation of Cyclin D2 and p21 following Apc loss in vivo
The Apc gene encodes the Adenomatous polyposis coli tumour suppressor protein, the germ line mutation of which characterizes Familial Adenomatous Polyposis (FAP), an autosomal syndrome characterized by multiple colorectal lesions. Inactivation of the Apc gene is recognized as a key early event in …
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