Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"AP2"”.
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Accountability and Privacy Preservation (AP2) in VANET Communications
<p> In my thesis I have studied the privacy and accountability issues present in VANET communications. The main challenge of my research is how to provide both vehicle privacy and accountability in single framework without existence of a single trusted entity. While several approaches have been …
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Untersuchungen zur Beeinflussung der Interaktion von AP 2 mit cytoplasmatischen Rezeptordomänen durch die Phosphorylierung und Dephosphorylierung von AP 2
… reguliert. Da die beiden Adaptorkomplexe AP1 und AP2 posttranslationell phosphoryliert werden, liegt die Vermutung nahe, daß die Interaktion zwischen den Adaptorkomplexen und den cytoplasmatischen Domänen bestimmter Rezeptorproteine und Transmembranproteine durch Phosphorylierung der …
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Signalbindung und Membraninteraktion von heterotetrameren Adaptorprotein-Komplexen
Die heterotetrameren Adaptorprotein-Komplexe AP1, AP2, AP3 und AP4 sind an der Sortierung von Transmembranproteinen in der Zelle beteiligt. APs interagieren mit den Sortierungssignalen von Transmembranproteinen und vermitteln dadurch ihre Aufnahme in Transportvesikel. Da jeder AP vermutlich an …
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Genetic analysis of stoned B/stonin 2 function in vivo
… gekoppelt ist und u. a. von Clathrin, Dynamin, AP2 und Synaptotagmin 1 abhängig ist. Stonin 2 ist ein Protein, das in Hirngewebe angereichert vorgefunden wird und sowohl in axonalen synaptischen Vesikel Clustern in Neuronen als auch in Clathrin/AP2 umhüllten Membraneinstülpungen in …
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AP2IX-4, a Cell Cycle Regulated Nuclear Factor, Modulates Gene Expression During Bradyzoite Development in Toxoplasma Gondii
… elements appears to be related to the Apetala-2 (AP2) family in plants. The Toxoplasma genome contains nearly 70 proteins harboring at least one predicted AP2 domain, but to date only three of these T. gondii AP2 proteins have been linked to bradyzoite development. We show that the putative T. …
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Site and Mechanism of Leptin's Antisteatotic and Insulin Sensitizing Actions in Lipodystrophic Liver
… site of leptin action, we treated lipodystrophic aP2-nSREBP-1c mice with a low dose of intracerebroventricular (icv) leptin. These studies showed that leptin acts on the brain mediating its peripheral effects indirectly via the CNS. The efferent pathways mediating leptin's peripheral effects are …
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Identification of transcription factor genes in plants
… Nine additional families, i.e., ABI3/VP1, AP2-EREBP, ARR-B, C2C2-CO-like, C2C2-Dof, PBF-2-like/Whirly, Pseudo ARR-B, SBP, and WRKY, predate the split between green algae and streptophytes. The identification of putative complete list of TFs has also allowed the delineation of …
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Lifecycle Progression And The Sexual Development Of The Apicomplexan Parasite Cryptosporidium Parvum
… analyses further confirmed four sex specific ApiAP2 genes, and ApiAP2s in Plasmodium are involved in stage-specific development. We intend to disrupt sexual development by targeting one of these ApiAP2s, and cgd4_1110 was confirmed as an essential, female specific ApiAP2. We engineered rapamycin …
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P21- ACTIVATED KINASE 4 AND ACTIN CYTOSKELETON DYNAMICS
… IS INHIBITED BY INCA (INDUCED IN NEURAL CREST BY AP2); AND 2) TO EXPLORE THE DIVERSITY OF ACTIN BINDING PROTEINS (ABPS) IN THE ACTIN POLYMERISATION AND DEPOLYMERISATION CASCADES DOWNSTREAM SIGNALLING CASCADES, SUCH AS PAK4. THE FIRST OBJECTIVE WAS ACHIEVED BY CRYSTALLISING THE PAK4: INCA COMPLEX …
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TMEM27: A Cleaved and Shed Plasma Membrane Protein That Stimulates Pancreatic Beta Cell Proliferation
… and is increased in islets of ob/ob, db/db and aP2- Srebp-1c transgenic mice with marked hypertrophy of the endocrine pancreas. Tmem27 is expressed in hormone positive cells at early stages of pancreas development and becomes restricted to pancreatic β cells in the mature pancreas. Biochemical …
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Uncoupling Lipid Metabolism from Inflammation in Adipose Tissue
… acid binding protein 4 (FABP4, also know as aP2) in macrophages suppresses inflammatory activation of the cells and contributes to whole body insulin sensitivity in an animal model. However, the mechanism of how FABP4 deficiency leads to the suppressed inflammatory was not well defined. In my …
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Lysine acetyltransferase Gcn5-B regulates the expression of crucial genes in Toxoplasma and its function is regulated through lysine acetylation
… We also demonstrate that GCN5b interacts with AP2-domain proteins, which are plant-like transcription factors in Apicomplexa. The interactions between GCN5b, AP2IX-7, and AP2X-8 were confirmed by reciprocal co-immunoprecipitation and revealed a “core complex” that includes the co-activator …
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Identification of a gene that makes-plants-gigantic-1: characterization of mpg1, a novel mutant of rice
… 2-Ethylene-Responsive Element-Binding Protein (AP2/EREBP) transcription factor superfamily, has markedly increased expression in mpg1 compared to wild-type plants. This transcription factor belongs specifically to the AP2/ERF subfamily, which members have been shown to play a role in growth, …
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Global transcriptional, post-transcriptional, and translational regulation during soybean seed and seedling development
… transcription factor genes encode AP2, zinc finger, NAC, WRKY and MYB families. Specific members of NAC and YABBY transcription factors showed a bell shaped expression pattern during soybean seedling development. The highest level of their expression was found in seedling …
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Genetic analysis of Ximenia Americana under natural conditions
… DNA: AT4G15910.1, SAD2, HXK1, ACC and ERF/AP2. Given the lack of genomic sequence information in X. americana background, primers for genomic amplification was design using A. thaliana genomic sequence information. Primers where designed to yield 100 bp genomic PCR product. Each of the …
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Analysis of transcription factors under sulphur deficiency stress
… we aimed at confirming the role of selected AP2 TF candidate genes in plant adaptation to sulphur unavailability. After preliminary characterisation of WRKY24 and MYB93 TF genes, we postulate that these factors are involved in a complex multifactorial regulatory network, in which WRKY24 and …
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Requirement for AMPA receptor endocytosis and long-term depression in ocular dominance plasticity
… tail of the AMPAR GluR2 subunit with the AP2 clathrin adaptor complex. We find that G2CT expression interferes with NMDAR-dependent AMPAR endocytosis and LTD, without affecting baseline synaptic transmission. When expressed in vivo, G2CT completely blocks the MD-induced depression of …
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Investigation of the physiological function of TTBK2 (tau tubulin kinase 2), a protein kinase mutated in spinocerebellar ataxia type 11 (SCA11)
… microtubule-associated proteins (tau, tubulin, MAP2) in vitro (Takahashi et al., 1995, Tomizawa et al., 2001). Since this discovery by Japanese scientists in 1995, considerable work has been invested in examining TTBK2’s relationship with aberrant tau phosphorylation and neurodegeneration in …
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Investigations of the assembly and function of the Toxoplasma micropore
… included known endocytosis proteins such as the AP2 adaptor complex, EPS15, and a dynamin-related protein (DrpC). It also included other proteins implicated in endocytosis in other apicomplexan parasites, such as UBP1 and K13. The micropore is an important part of the parasite’s pellicle since …
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Meristem regulation in the early divergent land plant Marchantia polymorpha
… study auxin response in gemma. I identify a ERF/AP2 transcription factor Mp ERF20 as a positive regulator of central stem cell fate. I interrogate the regulation of the division zone by cytokinins and identify Mp CYCD1 as a key regulator of cell division rates in the Marchantia meristem. I show …
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