Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"AP-2 complex"”.
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Characterisation of the AP-3 adaptor-like complex
… coat consists of two components, clathrin and adaptor (or AP) complexes, the AP-1 complex is associated with the clathrin coated vesicles that bud from the TGN and the AP-2 complex is associated with the clathrin coated vesicles that bud from the plasma membrane. A new type of adaptor-like …
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Conserved and Novel Properties of Clathrin-Mediated Endocytosis in Dictyostelium Discoideum
… accessory proteins, one of which is the adaptor complex AP-2, to co-ordinate vesicle formation. Disruption of genes involved in clathrin-mediated endocytosis causes embryonic lethality in multicellular animals suggesting that clathrin-mediated endocytosis is a fundamental cellular process. …
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Molecular basis of cargo sorting by endosomal trafficking machinery
… marking a critical junction between the Golgi apparatus, plasma membrane and endo-lysosomal pathway. It is at these early endosomal organelles that the sorting of a transmembrane protein determines if it is recycled for further use or degraded. Pathophysiological conditions from pathogens, rare …
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The mechanism of HIV-1 Nef-mediated downregulation of CD4
… clathrin-associated, plasma membrane-localized AP-2 complex in the Nef-mediated downregulation of CD4. In contrast, depletion of the related AP-1 and AP-3 complexes, which direct transport from the TGN and endosomes, had no effect. The requirement for AP-2 was subsequently confirmed in a human …