Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 21 for “"AP-2"”.
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Untersuchungen zur Beeinflussung der Interaktion von AP 2 mit cytoplasmatischen Rezeptordomänen durch die Phosphorylierung und Dephosphorylierung von AP 2
… z.B. Phosphorylierung reguliert. Da die beiden Adaptorkomplexe AP1 und AP2 posttranslationell phosphoryliert werden, liegt die Vermutung nahe, daß die Interaktion zwischen den Adaptorkomplexen und den cytoplasmatischen Domänen bestimmter Rezeptorproteine und Transmembranproteine durch …
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AB affects apoE transcriptionally through the activation of B-AR, cAMP and AP-2
… disease (AD) are amyloid beta protein (Aβ) and apolipoprotein E (apoE). We and others have reported that Aβ elevates apoE protein levels in astrocytes, which in turn could alter lipid trafficking and cell function. The mechanism for the Aβ-induced increase in apoE levels is not clearly …
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Recognition of basic sorting motifs within synaptic membrane cargo proteins by the clathrin-adaptor complex AP-2
… zentralen Nervensystem erfolgt über chemische Synapsen, die interzelluläre, asymmetrische Verbindungen zwischen einem Axon und dem Dendriten eines benachbarten Neurons darstellen. Synapsen bestehen aus einer präsynaptischen Signal freisetzenden und einer postsynaptischen Signal empfangenden …
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The mechanism of HIV-1 Nef-mediated downregulation of CD4
… clathrin-associated, plasma membrane-localized AP-2 complex in the Nef-mediated downregulation of CD4. In contrast, depletion of the related AP-1 and AP-3 complexes, which direct transport from the TGN and endosomes, had no effect. The requirement for AP-2 was subsequently confirmed in a human …
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Conserved and Novel Properties of Clathrin-Mediated Endocytosis in Dictyostelium Discoideum
… accessory proteins, one of which is the adaptor complex AP-2, to co-ordinate vesicle formation. Disruption of genes involved in clathrin-mediated endocytosis causes embryonic lethality in multicellular animals suggesting that clathrin-mediated endocytosis is a fundamental cellular process. …
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Synaptic vesicle protein 2A-dependent function and dysfunction at the presynapse
… for neuronal communication. At the presynapse, synaptic vesicles (SVs) undergo exocytosis to release neurotransmitter in response to incoming action potentials, and endocytosis to maintain the supply of SVs needed for further rounds of exocytosis. A key event during SV endocytosis is the …
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Characterisation of the AP-3 adaptor-like complex
… coat consists of two components, clathrin and adaptor (or AP) complexes, the AP-1 complex is associated with the clathrin coated vesicles that bud from the TGN and the AP-2 complex is associated with the clathrin coated vesicles that bud from the plasma membrane. A new type of adaptor-like …
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Role of Adaptor Proteins in MPR sorting
… der Rezeptoren erfordert die monomeren Adaptor-Proteine GGA und den heterotetrameren Adaptor-Protein Komplex AP-1. Wir generierten und analysierten chimere Proteine der Rezeptor-bindenden Untereinheit µ1 des AP-1 und der homologen µ2 Untereinheit des AP-2 Komplexes der Plasmamembran und …
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Function analysis of Xenopus NumbL in the context of primary neurogenesis
… Interaktion von NumbL mit dem endocytotischen AP-2 Komplex erbracht und das diese Interaktion essentiell für die Funktion von NumbL während der primären Neurogenese ist. Interessanterweise scheint die Inhibition der Neurogenese bei einem Knockdown von NumbL nicht auf einer Deregulierung des …
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Regulation of IGFBP-5 and Osteoblast Functions by Nuclear Factor I
… for transcription factor activator protein 2 (AP-2) and nuclear factor I (NFI). The work in this dissertation identifies the NFI gene family as an important regulator of IGFBP-5 transcription primarily in human, as well as murine osteoblasts. The mechanism of IGFBP5 gene regulation involves …
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Wechselwirkungen von Proteinen mit den zytoplasmatischen Domänen der Mannose-6-Phosphat-Rezeptoren
… mit den µ2- und µ3A-Untereinheiten der Adaptorkomplexe AP-2 und AP-3 im Hefe Two-Hybrid-System untersucht und durch Kopräzipitationsanalysen verifiziert. Die Wechselwirkung zwischen dem MPR46-CT und µ2 wird durch die C-terminalen Aminosäureste 49-64 der zytoplasmatischen Rezeptordomäne …
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Distribution and targeting of CLC-3
… expressed chloride channel that is present in synaptic vesicles and endosome/lysosome compartments. The channel is largely intracellular, but has been observed at the plasma membrane as well. The aim of this study was to identify the trafficking pathway for delivery of ClC-3 to intracellular …
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The Nonisothermal Stage of Magnetic Star Formation
… by employing the grey flux-limited diffusion approximation. Realistic temperature-dependent grain opacities are used that account for a variety of grain compositions. We have augmented the publicly-available Zeus-MP code to take into consideration all these effects and have modified several of …
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Genetic analysis of Kmt2d loss in tumorigenesis using genetically engineered mouse models
… and epithelial carcinoma. Biochemically, KMT2D shapes the cellular enhancer landscape as the major writer of the putative enhancer mark H3K4me1. Given the critical role of cellular enhancer landscape in determining cellular lineage in embryonic development, it is unknown whether enhancer …
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Identification of host factors required for cytosol entry by Shigella flexneri: Results of a genome-wide CRISPR/Cas9 screen
… protein KHDRBS1, known to act as a signalling adaptor and regulator of inflammatory responses, facilitates cytosol entry and replication by *Shigella*. I showed that the transcriptional regulator YY1 is also required for cytosol entry and replication. Both KHDRBS1 and YY1 are likely to act …
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Molecular basis of cargo sorting by endosomal trafficking machinery
… marking a critical junction between the Golgi apparatus, plasma membrane and endo-lysosomal pathway. It is at these early endosomal organelles that the sorting of a transmembrane protein determines if it is recycled for further use or degraded. Pathophysiological conditions from pathogens, rare …
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Characterization of the Human Adenovirus 19a E3/49K Protein
… unit, the early transcription unit 3 (E3), appears to encode exclusively proteins with immuno-modulatory functions. Recently, a novel open reading frame, E3/49K, was identified in the E3 region of the epidemic keratoconjunctivitis causing serotype Ad19a. The sequence predicts a type I …
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Estudio comparativo del perfil de los factores de riesgo cardiovascular clásicos entre los pacientes con artritis psoriásica y pacientes con psoriasis
… que la psoriasis y la artritis psoriásica (AP), al igual que otras enfermedades de base inmunológica, se asocian con una mayor prevalencia de comorbilidades cardiovasculares (CV). Esta frecuencia se asocia sólo en parte a una mayor presencia de factores de riesgo CV clásicos. Muy pocos …
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Down-modulation of the apoptosis receptor Fas and the EGF receptor by the adenovirus E3/10.4-14.5K proteins requires the concerted action of two distinct transport signals
… types of motifs are recognized by cellular adaptor proteins which select cargo for directed transport in clathrin-coated vesicles. FACS analysis of stable E3-transfectants expressing 10.4-14.5K mutant proteins revealed that residues contained within these putative transport motifs were …
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