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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"ANK"”.
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Characterising Novel Substrates of the Asparaginyl Hydroxylase FIH
… protein substrates were discovered containing ankyrin (ANK) repeat domains, although their activities were not affected by hydroxylation. FIH null mice display a metabolic phenotype which is not obviously linked to HIF regulation, supporting the existence of other important substrates of FIH. …
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Stability, folding and evolution of the tumour suppressor protein p16.
… The 156-amino acid protein consists of four ankyrin (ANK) repeats. The ANK repeat is a ubiquitous 33-residue sequence motif that adopts a β-hairpin-helix-turn-helix fold. Multiple repeats stack in a linear manner to produce an elongated structure that is stabilized predominantly by …
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Innate Lymphoid Cell Diversity in Pregnancy and Ovarian Cancer
… three major subsets of ascites derived NK cells (aNK). These include previously described CD56bright and CD56dim aNK subsets and an additional NKG2Ahigh KIRlo subset which expresses tissue resident markers (TR aNK). Upon PMA plus ionomycin treatment, the proportion of TR aNK cells producing XCL1 …
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Investigating the mechanisms and outcomes of Sprouty-2 S-acylation
… explored and although SPRY2 interacted with the ankyrin repeat (ANK) domain of zDHHC17 through a canonical mechanism, this mode of binding was dispensable for S-acylation. Binding assays suggested the presence of an additional lower affinity interaction site, which might involve amino acid …
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Regulation of Wnt signalling pathways by the Dishevelled DEP domain
… that Dishevelled DEP domain and Diversin ANK domain interact and that this interaction is crucial for the role of Diversin on noncanonical outputs. Using cell-bases assays, I concluded that overexpression of Diversin inhibits canonical Wnt signalling, consistent with previous results. …
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Convergence in Ergodic Theory
… the series of ergodic differences k=1infinity ( Ank+1f-Ankf ), where An denotes the usual ergodic averages, converges unconditionally for all functions f in some Lp space.
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The entocytherid ostracod fauna of the James and York River basins
… (Donnaldsoncythere ardis) seems to be endemic. Ankylocythere ancyla, Dactylocythere banana, Dt. falcata, Dt. suteri, Donnaldsoncythere ardis, Dn. hiwasseensis, Dn. truncata, Entocythere sp. A, E. internotalus and Phymocythere phyma occur on the crayfishes Cambarus acuminatus, C. b. bartonii, C. …
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Characterization of the vaccinia virus M1 protein on caspase inhibition and the MVA/5.2KB virus on immunogenicity
… Additionally, M1 features 14 predicted ANK repeat domains, a domain important for protein-protein interactions. Novel designed ANK repeat proteins (DARPins), are being created to specifically bind proteins, such as caspases, with high affinity. Therefore, information from the study of M1 …
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Petrogenesis of the Mesoproterozoic anorthosite, syenite and carbonatite suites of NW Namibia and their contribution to the metasomatic formation of the Swartbooisdrif sodalite deposits
… assemblage of both carbonatite generations of Ank + Cal + Ilm + Mag + Bt ± Ap ± pyrochlore ± sulphides in the main carbonatite body and Ank + Cal + Mag ± pyrochlore ± rutile in the ferrocarbonatite veins, their geochemical characteristics and the O and C isotope values of ankerite (8.91 to 9.73 …
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Impact of long-acting contraceptives on female genital tract cytokine profiles in a randomised controlled trial
… were assessed using Wilcoxon signed ank test. Fold changes in cytokine concentrations were compared between arms using Mann-Whitney U test. P-values were adjusted for multiple comparisons using a false discovery rate procedure. Overall cytokine profiles were compared using principal …
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A Developmental Pathway for Epithelial-to-Motoneuron Transformation in C. Elegans
… the axonal cytoskeleton genes unc-119, unc-44/Ank, and unc-33/Crmp as targets of hlh-16/Olig and ngn-1/Ngn, and demonstrate a previously unappreciated role for these genes in regulating the expression of motoneuron terminal differentiation genes. My results highlight intriguing similarities …
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Charakterisierung der konservierten Domänen des Transkriptionsfaktors N.t.BZI-1
… durch eine weitere Analyse der Interaktion mit ANK1 möglich. Es soll aufgeklärt werden, ob die detektierte Interaktion eine funktionale Beteiligung an der Translokation des BZI-1 in den Kern besitzt oder die DNA-Bindung beeinflusst. Die Funktion der putativen Kernlokalisierungssequenz in der …