Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 198 for “"ANG"”.
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Some crack problems in linear elasticity / by W.T. Ang
Errata inserted
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Impact of cable bleeding towards cable characteristics and performance in VDSL2 ang g.fast technologies
The application of copper cable in broadband services using very high-speed digital subscriber line transceivers 2 (VDSL2) (30a) has been proven to offer up to 50 Mbps upstream (US) and 100 Mbps downstream (DS) bandwidths at lower than 1 km distance. This application has been reckoned as a widely …
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Role of The Ang-Tie2 Pathway In The Invasive Recurrence of Gbm Following Anti-Vegf Therapy
… around areas of invasion. TEMs are a pro-angiogenic subset of circulating monocytes that express the Tie2 receptor. Our data demonstrates that TEMs have higher expression and activity of pro-invasive molecules, such as MMP2 and MMP9, than their Tie2 negative counterparts and are able to …
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Cardiovascular and renal effects of ANG II and NO in the newborn: roles of AT1Rs and /or AT2Rs
The vasoactive factors angiotensin II (ANG II) and nitric oxide (NO), and the balance between them play a major role in regulating cardiovascular and electrolyte homeostasis. During the perinatal period, both factors are elevated, yet their physiological roles have not been clearly defined. …
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Renale Effekte von Angiotensin I und seinen Metaboliten bei experimenteller Hypertonie
… Arbeit war es, die Effekte von allen als aktiv angesehenen Metaboliten des Renin – Angiotensin – Systems sowohl auf den renalen Gefäßwiderstand, als auch auf die stimulationsinduzierte Freisetzung des Neurotransmitters Noradrenalin am Modell der isoliert perfundierten Rattenniere in WKY-Ratten …
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The Role of Angiotensin-(1-7) in the Modulation of Angiotensin II-Dependent Cardiac Remodeling
Cardiac remodeling with associated changes in myocardial structure and function occurs in response to injury to the heart concomitant with chronic hypertension. The structural changes to the heart, including myocyte and vascular hypertrophy as well as interstitial and perivascular fibrosis, are …
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A ROLE FOR ANGIOTENSIN-(1-7) TO ATTENUATE ADVANCED GLYCATION END PRODUCT -INDUCED MYOFIBROBLAST TRANSITION IN THE NRK-52E RENAL PROXIMAL TUBULE CELL LINE
… evidence for a role of intracellular renin-angiotensin system (RAS) in cell signaling, function and cardiovascular pathologies. Diabetic nephropathy is a very common complication in which tubulointerstitial fibrosis may arise from epithelial to mesenchymal transition (EMT) of the proximal …
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STUDIES ON ANGIOTENSIN-(1-7) AND MITOCHONDRIA: THE ROLE OF AN INTRACELLULAR RENIN-ANGIOTENSIN SYSTEM WITHIN THE KIDNEY
… classic circulating hormonal system - the renin-angiotensin System (RAS), and specifically, the ACE-Ang II-AT1 receptor axis. We have focused strategically on investigating novel intracellular pathways by which Ang-(1-7) is generated and degraded since this alternative pathway within the kidney …
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Angiotensin II signalling in sensory neurons
Angiotensin II (Ang II) is a peptide associated with the regulation of blood pressure, though the elevated presence of Ang II in the inflamed bowel – and other inflamed tissues – and the presence of receptors for Ang II on sensory neurons may point to additional roles in nociception in inflammatory …
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Sex-Related Differences in Hypertension and Renal Injury: Role of the Renin-Angiotensin System
… in men than in premenopausal women. The renin-angiotensin system (RAS) contributes to the development and maintenance of hypertension. Angiotensin II (Ang II) and angiotensin-(1-7) are two peptides derived from the RAS that possess vasoconstrictive and vasodilatory actions, respectively. Ang II …
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ANGIOTENSIN-(1-7): A NOVEL SMALL MOLECULE FOR THE TARGETED TREATMENT OF TRIPLE NEGATIVE BREAST CANCER
ABSTRACT Soto-Pantoja, David Ricardo ANGIOTENSIN-(1-7): A NOVEL SMALL MOLECULE FOR THE TARGETED TREATMENT OF TRIPLE NEGATIVE BREAST CANCER Dissertation under the direction of E. Ann Tallant, Ph.D., Professor and Patricia E. Gallagher Ph.D., Associate Professor Triple negative breast cancer (TNBC), …
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EFFECT OF ANGIOTENSIN PEPTIDES ON VASCULAR REMODELING
… direct cost estimated at $286 billion each year. Angiotensin II (Ang II), one of the biologically active peptides of the renin-angiotensin system, elicits many maladaptive effects on the cardiovascular system. Over the past two decades, numerous studies demonstrated that the other biologically …
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Einfluss von Angiopoietin-1 und Angiopoietin-2 auf die Angiogenese im Ratten-Gliommodell
Angiopoietine spielen eine wichtige Rolle in der Angiogenese. Sie beeinflussen die Neubildung und das Wachstum von Blutgefäßen und sind an der Reifung von Gefäßen beteiligt. Außerdem sind Angiopoietine für die Erhaltung der Gefäßstabilität unverzichtbar. <br>Die Bedeutung der Angiopoietine in der …
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Group IV Cytosolic Phospholipase A2α Is Critical for the Development of Angiotensin II-Induced Hypertension and Associated Pathogenesis
<p>Angiotensin II (Ang II) activates cytosolic phospholipase A2α and releases arachidonic acid (AA) from tissue phospholipids. AA metabolites mediate or modulate one or more renocardiovascular effects of this peptide and have been implicated in hypertension. Since AA release is the rate limiting …
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The role played by angiotensin (1-7) in the regulation of renal haemodynamics and excretory function in anesthetized rats
… have demonstrated that intra- renal infusion of Ang (1-7) caused a diuresis and natriuresis that was proportional to the degree of activation of the Renin Angiotensin Aldosterone System (RAAS). This raised the question as why the magnitude of this diuresis and natriuresis was compromised in rats …
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Angiotensin-(1-7): A Peptide Hormone Inhibitor for the Treatment of Breast Cancer Targeting the Tumor Microenvironment
… in this dissertation was to determine whether angiotensin-(1-7) [Ang-(1-7)], an endogenous seven amino-acid peptide hormone of the renin-angiotensin system, inhibits the growth of HER2-amplified and ER-positive orthotopic breast tumors and to identify the molecular mechanisms for the …
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Angiotensin II-mediated Regulation of the Human Angiotensin II Type 1 Receptor Gene
The physiological responses of angiotensin II (Ang II) are mediated across the cell membrane through the angiotensin II type 1 receptor (AT1R), a heptahelical membrane protein coupled to trimeric G-proteins on the cytosolic side. AT1R on binding its ligand, Ang II, leads to downregulation of …
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New Advances on the Biochemical Pathways in the Reninangiotensin System in Hypertension and their role in Cardiac Structure and Function
… are actually controlled. Because the renin‐angiotensin system (RAS) plays a major contributing role to the pathophysiology of hypertension and heart disease, the studies outlined in this dissertation traverse the complexities of the biochemical pathways within the cardiac renin‐angiotensin …
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Cytochrome P450 1B1 and 12/15 Lipoxygenase Interaction in Paraventricular Nucleus in Angiotensin II-induced Hypertension in Females
<p><strong>Background:</strong> Angiotensin (Ang) II releases arachidonic acid (AA) from tissue phospholipids that is metabolized by 12/15-lipoxygenase (ALOX15) generating 12(S)- and 15(S)-hydroxyeicosatetraenoic acid (HETE) which have been implicated in cardiovascular and renal diseases. This …
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