Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 48 for “"ANCA"”.
-
Veseérintettséggel járó ANCA-pozitív vasculitisek gyermekkorban
… hogy az érfalak gyulladását okozzák. Az ANCA-asszociált vasculitisek (AAV) közé tartozó kórképek a mikroszkópos polyangiitis, a granulomatosis polyangiitissel és az eosinophil granulomatosis polyangiitissel. A betegség korai felismerése és a megfelelő terápia elindítása kiemelkedően …
-
B cell therapy in ANCA-associated vasculitis
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare autoimmune disease with a UK prevalence of 250 per million. The immunopathogenesis includes neutrophil activation by B cell-derived ANCAs, activation of the alternative complement pathway, and dysregulated T cell …
-
T Helper Cell Dysfunction in ANCA Associated Vasculitis
Anti-neutrophil cytoplasmic antibody (ANCA) associated vasculitis (AAV) is an autoimmune disease characterised by inflammation of small blood vessels that leads to organ dysfunction. Auto-reactive B cells produce pathogenic antibodies against the neutrophil enzymes, myeloperoxidase (MPO) and …
-
Proteinase 3 and Neutrophil Apoptosis in ANCA-Associated Systemic Vasculitis
ANCA-Associated Systemic Vasculitis (AASV) is characterized by leukocytoclasis- dying neutrophils surrounding small blood vessels. Previous studies have shown increased plasma PR3 and increased proportion of neutrophils expressing plasma membrane-associated PR3 (mPR3+). Neutrophils were isolated by …
-
The development of a humanised mouse model of ANCA associated vasculitis
Anti-neutrophil cytoplasmic autoantibodies (ANCA), targeting the neutrophil protein granules myeloperoxidase (MPO) and proteinase 3 (PR3), activate neutrophils in vitro, and are associated with a systemic autoimmune vasculitis, in which a pauci-immune crescentic glomerulonephritis is common. The in …
-
The role of complement and granulocyte colony stimulating factor in ANCA associated vasculitis
Hieutrophil cytoplasmic antibody (ANCA) associated vasculitis is a systemic disease i affects the kidneys, lungs, and other tissues. ANCA were first described in patients i focal necrotising glomerulonephritis in 1982, with myeloperoxidase )) and proteinase 3 (PR3) subsequently shown to be the …
-
What are the informational needs of patients with ANCA Associated Vasculitis? a Mixed Methods Study
Background: The ANCA –associated vasculitides (AAVs) are a group of rare, potentially life-threatening conditions which if untreated can be fatal. Little is known about the information needs of people with AAV. Objectives: To explore what it is like to be diagnosed with AAV and to find out the …
-
Anti-neutrophil cytoplasmic antibody (ANCA) testing at Groote Schuur Hospital: Adherence to indications for testing
… the anti-neutrophil cytoplasmic antibody (ANCA) testing practices in a tertiary hospital in South Africa.
-
Kommt den anti-neutrophilen-cytoplasmatischen Antikörpern und den anti-Saccharomyces-cerevisiae Antikörpern eine Bedeutung in der Diagnostik chronisch entzündlicher Darmerkrankungen zu?
… anti-neutrophile-cytoplasmatische Antikörper (ANCA-Test) und der andere auf anti-Saccharomyces-cerevisiae Antikörper (ASCA-Test). Um die Aussagekraft dieser beiden Tests beurteilen zu können, untersuchten wir Seren von 32 Morbus Crohn und 19 Colitis ulcerosa Patienten und verglichen diese mit …
-
Wegener'sche Granulomatose
… die mit Anti-Neutrophilen-Antikörpern (ANCA, anti neutrophil cytoplasmic antibody) assoziiert sind. Mit Hilfe der indirekten Immunfluoreszenz lassen sich ANCA im Serum der meisten WG-Patienten nachweisen. Die mit WG assoziierten sog. “klassischen” ANCA (c-ANCA) erkennen spezifisch …
-
Immunological responses following surgery in ulcerative colitis
… ulcerative colitis (UC). A high prevalence of ANCA was found in UC but not in Crohn’s disease. ANCA positive UC sera were found to recognise a variety of antigens, namely lactoferrin, cathepsin G, enolase and elastase. Confocal microscopy revealed maximum immunofluorescence for P-ANCA to …
-
Diagnostic and prognostic aspects of anti-neutrophil cytoplasmic antibodies in systemic vasculitis
… of anti-neutrophil cytoplasmic antibodies (ANCA) in systemic vasculitis is investigated. The clinical significance of a capture enzyme-linked immunosorbent assay (ELISA) based on the monoclonal antibody 4A3 for detection of antibodies against proteinase 3 (PR3-ANCA) was evaluated and found …
-
Heterogeneity of injury in vasculitis: influence of anti neutrophil cytoplasm antibody IgG subclass and endothelial susceptibility.
This study examined IgG subclass in ANCA associated vasculitis and glomerular endothelial cell (GEC) phenotype predisposes to injury. Using the flow model, interaction of neutrophils with normal immunoglobulin subclasses was compared to interaction with subclasses of ANCA IgG. Neutrophils were …
-
Plasmablasten mit einem mukosalen Phänotyp als Biomarker für die Granulomatose mit Polyangiitis?
… antineutrophiler zytoplasmatischer Antikörper (ANCA) und damit als wesentliche Akteure der Krankheitsentstehung. Im Rahmen dieser Arbeit wurden daher das B- und Plasmazellkompartiment sowie das Serumzytokinprofil von 29 GPA-Patienten im Vergleich zu 28 gesunden Kontrollen analysiert. Die …
-
Some Contemporary Diagnostic Aspects of Inflammatory Bowel Diseases in Children and Adolescents // Някои съвременни диагностични аспекти на възпалителните заболявания на червата при деца и юноши
… протеин, фибриногена, фекалния калпротектин, p-ANCA и c-ANCA) имат определена диагностична и диференциално-диагностична стойност при тези заболявания. Находките от фиброколоноскопията, абдоминалната ултрасонография, компютърната томография, ендоскопията, биопсията и фиброгастроскопията …
-
Improving patient outcomes in systemic vasculitis
… diagnostic criteria, morbidity and mortality in ANCA-associated vasculitis with a focus on cardiovascular disease and neuropathy, and validation of outcome measures which are now endorsed for use in trials of ANCA-associated vasculitis. The overarching goal of all the work presented is to improve …
-
Expression von rekombinanten Antigenen zur Untersuchung der Autoantikörperspezifität bei Goodpasture-Syndrom
… Untergruppe von Vaskulitis-Fällen, die neben ANCA auch Anti-GBM-Autoantikörper vorweisen. Klinisch verlaufen diese Fälle oftmals sehr ähnlich wie ein Goodpasture-Syndrom. Die neun untersuchten Patienten mit C-ANCA (n=7) bzw. P-ANCA (n=2) und Anti-GBM-Autoantikörpern reagierten alle mit der …
-
The Genetics of Anti-Neutrophil Cytoplasmic Antibody Associated Vasculitis (AAV)
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a multi-systemic autoimmune disorder with evidence of circulating pathogenic ANCA. There are two main antigenic targets: proteinase 3 (PR3) and myeloperoxidase (MPO). Previous genome-wide association studies (GWAS) have …
-
The Role of Von Hippel-Lindau Protein in the Glomerulus
… such as antineutrophil cytoplasmic antibodies (ANCA) are believed to play a major role. In this thesis, we show that deletion of the Von Hippel-Lindau gene (Vhlh) from intrinsic glomerular cells of mice is sufficient to initiate a necrotizing crescentic glomerulonephritis and the clinical …
Page 1 of 3