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Showing 1 to 2 of 2 for “"AN2690"”.
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PTEN-5-HT2CR Complex: An Ideal Target for Developing Treatment to Restore the Functioning of 5-HT2CR; An Attempt to Minimize the Development of Antimicrobial Resistance
… reaction are ideal targets for antibacterials. AN2690, a benzoxaborole derivative, shows great antibiotic activity by trapping tRNALeu in the editing domain. Inspired by AN2690 and other benzoxaborole derivatives, we designed (S)-3-Aminomethyl-7-(3-hydroxy-propoxy)-3H-benzo[c][1,2]oxaborol-1-ol …
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Leucyl-tRNA synthetase: dynamic subcellular relocalization and drug resistance mechanism
… (LeuRS) and therefore of protein synthesis. AN2690 (5-fluoro-1,3-dihydro-1-hydroxy-2,1-benzoxaborole) blocks fungal cytoplasmic LeuRS by trapping tRNALeu in the editing site of the enzyme’s CP1 domain. Some resistant mutations are located outside of the CP1 hydrolytic editing active site. …