Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"AMPK signaling"”.
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Overcoming Tumor Drug Resistance By Activating Amp-Activated Protein Kinase And Destabilizing Oncoproteins
… phenotype. AMP-activated protein kinase (AMPK) is a well-known major cellular energy sensor, which negatively regulates metabolic pathways such as protein synthesis, fatty acid oxidation and glucose consumption. Activation of AMPK may suppress metabolic activities that are in favor of …
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The Transcription Factor TFEB Protects Against Cardiac Hypertrophy by Increasing Lysosomal Capacity and Activating AMPKα
… play important roles in this remodeling, as do signaling pathways associated with the lysosome, such as AMPK and mTOR, a negative and positive regulator of hypertrophy, respectively. Yet, lysosomal biogenesis and function remain poorly studied in the heart, and the possible role of the lysosome …
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Regulation of CaMKKβ Dependent Signaling Pathways
… (CaMKIV), and the AMP-dependent protein kinase (AMPK) in a number of physiological pathways including learning and memory formation, neuronal differentiation, and regulation of energy balance. The purpose of the work presented in this dissertation is to better understand the regulation of …
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DYSREGULATION OF AMP-ACTIVATED PROTEIN KINASE SIGNALING IN ALZHEIMER’S DISEASE
… disease. AMP-activated protein kinase (AMPK) is a master energy sensor which can sense the ratio of AMP/ATP and regulates catabolic and anabolic pathways to keep the energy metabolism in balance, and has been found to play an important role in the pathogenesis of Alzheimer’s disease. …
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The Effect of Cancer Cachexia Progression on the Feeding Regulation of Skeletal Muscle Protein Turnover
… stimuli that are controlled by mTORC1 and AMPK signaling. During cachexia, altered protein turnover is thought to occur through suppressed anabolic signaling via mTORC1, coinciding with the chronic activation of AMPK. While progress has been made in understanding some of the mechanisms …
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Mechanism of Metformin Action in Dermal Fibroblasts
… primary cause of hyperglycemia is dysregulated AMPK signaling and mitochondrial complex activity, which regulates both glucose uptake and cellular energy status. Current therapeutic methods to counter hyperglycemia include tight euglycemic control and/or intensive insulin treatment, which are …
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Investigation of the Biological Effects of Rosemary (Rosmarinus Officinalis L.) Extract in Human Lung Cancer Cells
… activation and/or expression of Akt, ERK and AMPK, signaling molecules which regulate cell proliferation and survival. RE shows potential as an anticancer agent and should be further investigated.
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Regulation of Systemic and Cellular Metabolism In Prostate Cancer By Camkk2 and Elucidation of Atgl’S Role In Disease Progression
… of the 5' AMP-activated protein kinase (AMPK), a master regulator of metabolism that was first described in cancer as a tumor suppressor, but was later shown to possess context-dependent, oncogenic roles. Therefore, it is important to distinguish the oncogenic pathways modulated by AMPK …
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Identifying Diagnostic Biomarkers: Gene Expression Profiling Leptin in Dental Pulp Tissue
… in hypoxic conditions shows down-regulation of AMPK signaling, which is related to cellular energy, transcription factors p65, NF-kappa-B and MAP Kinases associated with transcription regulation and differentiation. Up regulation of LEP/LEPR is associated with fat metabolism and both immune and …
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Investigating IL-15 Metabolic Impact and Its Mechanism of Action in Skeletal Muscle Cells
… and 2) to determine whether IL-15 activates the AMPK signaling. L6 myotubes were exposed to different concentrations of IL-15 and different metabolic parameters were assayed namely; oxygen consumption, glucose uptake, fatty acid oxidation, Glucose transporter 4 (GLUT4) translocation, oxidative …
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Examining Mechanisms and Functional Significance of Adiponectin Stimulated Autophagy in Cardiometabolic Diseases
… beneficial effects are mediated through AMPK signaling. AMPK is a master regulator of energy metabolism and activated upon low energy status. AMPK activates multiple cellular process to generate energy including autophagy. Autophagy is a conserved catabolic process which confers an …
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Involvement of AMP-activated protein kinase in differential regulation of appetite between lines of chickens selected for low or high juvenile body weight
… the hypothalamic AMP-activated protein kinase (AMPK) system and (2) if this alteration contributes to the dissimilar feeding response to various appetite modulators between HWS and LWS lines. Compared to HWS, LWS chickens had higher levels of AMPK α and acetyl-CoA carboxylase (ACC) …
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Impaired Ulk1 Ser555 Phosphorylation Promotes Amino Acid Reliance and Links Mitochondrial Inefficiency to Systemic Metabolic Inflexibility
… serves as a nutrient-sensing hub regulated by AMPK and mTORC1. AMPK activates Ulk1 via phosphorylation at serine 555 (S555) during energetic stress, while mTORC1 inhibits Ulk1 under nutrient-rich conditions. To investigate the specific role of Ulk1(S555), we used global Ulk1(S555A) knock-in …
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Role Of Thromboxane Receptor-Alpha In Prostate Cancer Progression
… TP-beta (TPβ), which have common and distinct signaling pathways. Of the two TP receptor isoforms, studies have shown that TPα impacts tumor growth and progression of lung cancer. Previously our studies demonstrated that activation of Thromboxane receptor by TXA2 agonists could regulate …
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Identification and Targeting of Downstream Ar-Camkk2-Mediated Mechanisms For The Treatment of Advanced Prostate Cancer
… of prostate cancer and, therefore, AR-regulated signaling events are essential for the development and progression of the disease. Despite their initial effectiveness, drugs targeting AR eventually fail as sustained inhibition of receptor activity remains a challenge. Previously, …
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Plasma Extracellular Vessicles, Exercise Resistnace and Cancer
… This study identified dysregulation of diverse signaling pathways, including glycogen synthesis, myogenesis and AMPK signaling in obese individuals. Finally, we utilized the biomarker potential of SEC-MS to identify differences in protein abundance and composition in EVs isolated from …
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Linking Environmental Toxicant Exposure To Diabetes Susceptibility
… we observed that dioxin treatment stimulated the AMPK signaling pathway, which is known to have a suppressive effect on PEPCK gene expression.</p> <p>Although Pb exposure and blood Pb levels have declined over the past decade, the interaction between obesity and Pb exposure is a relevant issue in …
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Understanding The Role of Sumoylation In Regulating Lkb1 Function
… the energy sensor AMP-activated protein kinase (AMPK), directly associating it with the regulation of energy balance in cells. During energy stress, LKB1 phosphorylates AMPK at threonine 172 (T172) resulting in AMPK activation. This leads to the inhibition of anabolic pathways such as fatty acid …
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The Interaction of Obesity and Age and their effect on Adipose Tissue Metabolism in the Mouse
… metabolic pathways regulated by the peroxisome, AMPK, insulin and PPARγ signaling were activated in the initiation of obesity but inhibited in the adipose tissue of old ob/ob mice along with up-regulated inflammation pathways. The brown and white adipose tissue of PPARα-knock-out mice were also …