Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 36 for “"AMPAR"”.
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Regulation of AMPA receptor acetylation and translation by SIRT2 and AMPK: the molecular mechanisms and implications in memory formation
… acid receptors (AMPARs) are ligand-gated glutamatergic ion channels that mediate most excitatory neurotransmission in the brain. Alterations in AMPAR synaptic accumulation mediate synaptic plasticity, including long-term potentiation, long-term depression and …
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The role of glutamate transporters and the scaffolding protein IQGAP1 in the regulation of AMPA receptor trafficking and turnover
… propionic acid)-type glutamate receptors (AMPARs), and this process is thought to underlie higher brain functions such as learning and memory. During excitatory synaptic transmission, the presynaptic neuron releases glutamate which activates AMPARs that, in turn, conduct postsynaptic …
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Identification and functional characterisation of synaptic AMPA receptor-interacting proteins
… primarily by AMPA-type glutamate receptors (AMPARs), and is crucial for the transfer and storage of information in the brain. The AMPAR engages in numerous protein interactions, modulating receptor trafficking, channel gating, synaptic positioning, and ultimately synaptic strength. iGluR …
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Super-resolution imaging of glutamate receptors in cultured hippocampal neurons under basal and LTP conditions
… glutamate synaptic receptors—the AMPA receptors (AMPARs) and NMDA receptors (NMDARs)—located on the postsynaptic membrane of nerve cells, are crucial for neuronal health, learning and memory formation. They can exist under basal condition where no synaptic strength change occurs, and chemically …
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Molecular Mechanisms Controlling Excitatory Synaptic Transmission
… binds to postsynaptic AMPA receptors (AMPARs). Crucially, synaptic strength is plastic, and control of this strength is essential for fundamental brain functions such as the processing and storage of information. Synaptic transmission is controlled by tuning the response of postsynaptic …
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Studies of nicotinic acetylcholine receptors containing α4 and α6 subunits in nicotine-induced synaptic plasticity in brain reward areas
… including the enhancement of AMPA receptor (AMPAR) function. This enhancement sensitizes the VTA to excitatory input and promotes drug seeking in animal models. However, which nAChR subtype(s) are responsible for initiating these cellular changes is poorly understood. nAChRs containing the α6 …
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NMDAR-PSD95-nNOS Axis-Mediated Molecular Mechanisms in the Basolateral Amygdala Underlying Fear Consolidation
… acid receptor (AMPAR)-mediated current and synaptosomal AMPAR GluR1 subunit trafficking in the BLA; while during the late stage (24h after fear acquisition), we detected a combination of enhanced AMPAR- and NMDAR-mediated currents, increased synaptosomal NMDAR …
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Requirement for AMPA receptor endocytosis and long-term depression in ocular dominance plasticity
… propionic acid receptors (AMPARs). Although it has been shown that MD similarly causes a loss of AMPARs from visual cortical synapses, the contribution of this change to OD plasticity has not been established. Here we develop a herpes-simplex virus (HSV) vector to express a …
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Activity-dependent mitochondrial signaling drives GLR-1 dynamics and behavioral sensitization in C. elegans
The AMPA sub-type of glutamate receptors (AMPARs) are necessary for excitatory synaptic function. Specifically, dynamic AMPAR transport and localization throughout dendrites is critical for synaptic strengthening as well as learning and memory. We are beginning to unravel the effects of neuronal …
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AMPA receptor diversity and dynamics during excitatory synaptic transmission
… postsynaptic side. By employing AMPA receptors (AMPARs), the postsynaptic cell can respond to presynaptic glutamate release with millisecond-timescale precision. The diversity of AMPAR subtypes across the brain is vast, with each subtype providing unique signalling properties. The composition and …
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Ampa Receptor Dysregulation And Therapeutic Interventions In A Mouse Model Of Cdkl5 Deficiency Disorder
… decrease in membrane-bound AMPA receptor (AMPAR) subunit GluA2 as well as decreased GluA2:GluA1 in the hippocampus of R59X mice, suggesting an increase in hippocampal GluA2-lacking AMPARs, which are calcium permeable and have significant roles in regulating neuronal plasticity and …
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Ca2+ dependant synaptic modification
… LTD, 3. evidence that phosphorylation of AMPAR leads to insertion of AMPAR.
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Targeting AMPA Receptor Modulation during Early Life Adversity: A Mediator for Threat Associated Memories
… of these studies was in identifying the role of AMPAr on transitional threat memory processing at three ages of infancy, and the juvenile stage, to understand how the brain at different stages of life responds and processes threat.</p> <p>Adult rats exposed to threat exhibit impaired long-term …
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Investigating the Molecular Function of APP Interacting Proteins in Synaptic Neuromodulation
… isoxazolepropionic acid glutamate receptors (AMPARs), which mediate fast excitatory synaptic transmission and are often dysregulated in neurological disorders. Finally, we examined whether epigenetic methylation changes contribute to synaptic impairments by comparing Cntn4 knockout (KO) mice …
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Synaptic Mechanisms Underlying Treatment of Depression and Bipolar Disorder
… treatment caused a significant decrease in AMPAR-mEPSC amplitude, which requires both BDNF and its high affinity receptor, TrkB. Additionally, chronic lithium treatment caused a significant decrease in surface expression of the GluA1 subunit of the AMPAR. Collectively, this data demonstrates …
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Withdrawal from Voluntary Oral Methamphetamine Reveals Female Specific Susceptibilities to Behavioral Deficits and Neurochemical Perpetuators of Neurotoxicity and Drug Seeking Behavior
… κOR signaling to assess female susceptibility to AMPAr trafficking dysfunction and drug seeking following withdrawal from MA. </em>These experiments were done to understand<em> </em>the<em> 4. neurochemical shifts underlying female-specific vulnerabilities to persistent behavioral and cognitive …
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The regulation of neuronal excitability by epilepsy-associated gene Nedd4-2
… which our lab has identified. AMPA receptors (AMPARs) are the most commonly found receptors in the mammalian nervous system, mediating fast excitatory synaptic transmission. Their distribution and activity are regulated by post-translational modifications, such as ubiquitination and …
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
… pooling and therefore resulted in an increase in AMPAR desensitization at the hippocampal Schaffer-CA1 synapse. Overall my studies focused on the effects of glutamate spillover onto both NMDA and AMPA receptors at the Schaffer-CA1 synapse in hippocampal slice.
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THE EFFECT OF SPILLOVER ONTO IONOTROPIC GLUTAMATE RECEPTORS AT THE SCHAFFER-CA1 SYNAPSE IN HIPPOCAMPAL SLICE
… pooling and therefore resulted in an increase in AMPAR desensitization at the hippocampal Schaffer-CA1 synapse. Overall my studies focused on the effects of glutamate spillover onto both NMDA and AMPA receptors at the Schaffer-CA1 synapse in hippocampal slice.
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Investigating endothelin receptor B signalling during myelination
… ErbB receptors, protein kinase C ε, NMDAR and AMPAR. Functional analyses of a subset of these factors elucidate how EDNRB signalling, potentially connecting signals from a range of cell types, ensures correct adequate myelination in the CNS.
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