Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 49 for “"AMPA-receptors"”.
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Structural and Functional Effect of Phosphorylation On Ampa Receptors
… and Functional Effect of Phosphorylation on AMPA Receptors</h1> <p>Cailtin Edmunds show you, BA</p> <p>Advisory Professor: Vasanthi Jayaraman, Ph. D.</p> <p>The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor is the primary contributor to neuronal fast excitatory …
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Quantitative DNA-paint imaging of AMPA receptors in live neurons
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
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MOLECULAR FACTORS THAT INFLUENCE THE BINDING OF AGONISTS TO AMPA RECEPTORS
<p>AMPA receptors mediate excitatory synaptic transmission throughout the central nervous system via activation by their natural agonist glutamate. Several other molecules have been recognized as receptor agonist or antagonist, and recently allosteric modulators have been developed that potentiate …
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Molecular alterations of AMPA receptors and their effects on hippocampus dependent tasks
… (GluR-A-/-) mice showed that GluR-A containing AMPA receptors are required for working memory, strengthened by those findings that expression of a transgenic GluR-A subunit in the forebrain of GluR-A-/- mice partially rescues this memory deficit. In a spatial reference memory task GluR-A-/- mice …
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Exploring the effects of 5-HT2A and AMPA receptors on brain 5-HT via a mechanism-based pharmacodynamic model
… in PFC would increase serotonin levels by an AMPA-dependent mechanism in both DRN and PFC. Enhancement of the 5-HT in DRN may inhibit 5-HT level in PFC by 5-HT 1A receptor. This becomes the full feedback loop system. While 5-HT levels in the PFC have been well studied, pathway that modulate …
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Studying synaptic organization and dynamics of AMPA receptors in primary neuronal cultures and brain tissue using super-resolution fluorescence microscopy
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-12-01
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Super-resolution imaging of glutamate receptors trafficking at live synapses
… from presynapse via glutamate receptors, mainly AMPA receptors and NMDA receptors. Trafficking of AMPA receptors in and out of synapses affect synaptic plasticity, which underlies the molecular mechanism of learning and memory. Lateral diffusion of AMPA receptors near synapses …
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Functional Characterization of Hippocampal Synapses in a Mouse Mutant of the Dystrobrevin Binding Protein 1 (DTNBP 1) Gene
… independent functional characterization of hippocampal synapses in sandy mice, which contain a spontaneous deletion in the DTNBP 1 gene resulting in the loss of expression of dysbindin, the protein that it encodes. I had observed enhanced excitatory basal synaptic transmission at the CA3-CA1 …
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Understanding the activation-deactivation mechanism of glutamate receptor proteins at the single molecule level
… These receptor proteins, such as NMDA and AMPA receptors, are structurally diverse and house multiple extracellular and intracellular binding sites, which can modulate activated (open) or deactivated (closed) states of the ion channel. The gating action (activation and deactivation) of the …
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Glutamate Receptor-Mediated Taurine Release From The Hippocampus During Oxidative Stress
… ischemia and has been directly linked to hippocampal swelling and cytotoxic brain edema in vitro. Swollen brain cells activate volume regulatory mechanisms including a significant efflux of the endogenous sulfonic amino acid taurine via volume-regulated anion channels (VRACs). Studies in brain …
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Visualizing the dynamics of ionotropic glutamate receptors using atomic force microscopy
… different subclasses of ionotropic glutamate receptors (iGluRs): AMPA, kainate and NMDA receptors, and triggers a cation influx that generates synaptic currents crucial to brain function. Significantly, iGluRs are implicated in various neurological disorders, such as depression, schizophrenia, …
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A structure-function analysis of the marine toxin neodysiherbaine and its synthetic analogs on kainate receptors
… including pain and epilepsy. These receptors are selectively targeted by a number of natural and synthetic ligands. The goals of this project were to identify compounds with unique specificity for kainate receptors and to gain insight into structural determinants of affinity and …
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The Role of Glutamate in the Medial Prefrontal Cortex in the Acquistion and Expression of Conditioned Approach
… the acquisition of conditioned approach, NMDA receptors were blocked with AP5 prior to each of the three conditioning sessions. For expression, AMPA receptors were blocked with CNQX prior to the CS-only test session. The results from the acquisition experiments show substantially greater …
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Understanding The Single Channel Behavior Of Glua3 Receptors
… the functional mechanism of glutamate receptors. AMPA receptors in particular were the first in which structure was correlated to function; specifically, the structures of the isolated ligand binding domain (LBD) bound to different agonists, partial agonists, and antagonists, were …
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Elucidating the Interplay Between Lipids and Membrane Proteins Using Multiscale Computer Simulations
… I studied the interaction of G Protein-Coupled Receptors (GPCRs) with lipids at a family-wide level. Plenty of other computational studies had shown specific lipid-protein interactions for a handful of GPCRs but with quite different outcomes on their number, location, and lipid identity. In my …
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Organization of Postsynaptic Proteins via the Neuronal Cytoskeleton
… agents and detergent extraction of primary hippocampal cultures to test directly the role of the cytoskeleton in localizing neurotransmitter receptors, and potential anchoring and signal transducing proteins at postsynaptic sites. Neurons were treated with latrunculin A to depolymerize actin, …
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Dendritic sensitivity to the direction of synaptic firing mediated by inhibition; and, The effects of the release timecourse of neurotransmitter on synaptic transmission
… pathway present in mature synaptic transmission (AMPA receptor) (Malenka and Nicoll 1997). The possible cause of this abnormality was either that AMPA receptors were lacking on the postsynaptic side, or that something else in the process of synaptic transmission rendered them inoperable.
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Swarna Ramaswamy_Thesis
… of some of the excitatory neuro transmitter receptors. Signal transmission depends on the ability of the extracellular receptor segment and ion channel segment coordinating their movement to produce the one singular effect. My thesis work focuses on using various spectroscopic and molecular …
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The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… over-activation of post-synaptic glutamatergic receptors has long been established as a key contributor to neuronal death. Also contributing to ischemic/reperfusion-induced neuronal death is oxidative stress, chemically defined as a pathologic state within the cell arising from the increased …
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