Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"AMPA Receptor"”.
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AMPA receptor diversity and dynamics during excitatory synaptic transmission
… into a pre and postsynaptic side. By employing AMPA receptors (AMPARs), the postsynaptic cell can respond to presynaptic glutamate release with millisecond-timescale precision. The diversity of AMPAR subtypes across the brain is vast, with each subtype providing unique signalling properties. The …
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Single-molecule FRET analysis of the dynamics of AMPA receptor
… of GluR2, a subunit of the ionotropic glutamate/AMPA receptor. The GluR2-SIS2 molecule was determined to have a more open cleft when the natural ligand glutamate is not present as compared to when glutamate is bound to the molecule. The apo and Glutamate-bound GluR2-S1S2 molecules in solution …
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Identification and functional characterisation of synaptic AMPA receptor-interacting proteins
… release from one neuron acts on the postsynaptic receptors of another, facilitating transfer of electrical impulses between neurons. At glutamatergic synapses, ionotropic glutamate receptors (iGluRs) respond to presynaptically released L-glutamate, the predominant excitatory neurotransmitter. …
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Cerebellar granule cell-specific deletion of the AMPA receptor subunit GluR-D gene
… und ihrer Sequenzähnlichkeit. Diese sind die AMPA(alfa-amino-3-hydroxy-5-methylisoxazole-4-propionic acid)-, und Kainat- und NMDA(N-methyl-D-aspartate)-bevorzugenden Rezeptoren. AMPA-Rezeptoren vermitteln schnelle erregende Weiterleitung an den meisten Synapsen des ZNS. Sie werden aus …
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Requirement for AMPA receptor endocytosis and long-term depression in ocular dominance plasticity
… the ratio of NR2A to NR2B N-methyl-d-aspartate receptor (NMDAR) subunits. Facilitated by the decreased modification threshold, open-eye responses are strengthened via homosynaptic longterm potentiation (LTP). One established LTD mechanism is a loss of sensitivity to the neurotransmitter …
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Ampa Receptor Dysregulation And Therapeutic Interventions In A Mouse Model Of Cdkl5 Deficiency Disorder
… observed a specific decrease in membrane-bound AMPA receptor (AMPAR) subunit GluA2 as well as decreased GluA2:GluA1 in the hippocampus of R59X mice, suggesting an increase in hippocampal GluA2-lacking AMPARs, which are calcium permeable and have significant roles in regulating neuronal …
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Targeting AMPA Receptor Modulation during Early Life Adversity: A Mediator for Threat Associated Memories
… of these studies was in identifying the role of AMPAr on transitional threat memory processing at three ages of infancy, and the juvenile stage, to understand how the brain at different stages of life responds and processes threat.</p> <p>Adult rats exposed to threat exhibit impaired long-term …
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A Single Alcohol Pre-exposure Alters Dorsolateral Striatal AMPA Receptor Dependent Binge and Compulsive-like Drinking
… in regulating this inflexible behavior. AMPA receptors have been implicated in both goal-directed (dorsomedial striatal dependent) and DLS dependent inflexible behaviors with antagonism in the DLS and general DLS inhibition altering inflexible behavior including habit and compulsion. …
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Ampa Receptor Allosterism: Measurement of The Conformational Changes In The Ligand Binding Domain of A Functional Receptor
Ionotropic glutamate receptors are important excitatory neurotransmitter receptors in the mammalian central nervous system that have been implicated in a number of neuropathologies such as epilepsy, ischemia, and amyotrophic lateral sclerosis. Glutamate binding to an extracellular ligand binding …
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The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… over-activation of post-synaptic glutamatergic receptors has long been established as a key contributor to neuronal death. Also contributing to ischemic/reperfusion-induced neuronal death is oxidative stress, chemically defined as a pathologic state within the cell arising from the increased …
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The Role of NADPH Oxidase in Ischemia/Reperfusion-Induced Alterations to AMPA Receptor Trafficking and NMDA Receptor Function
… over-activation of post-synaptic glutamatergic receptors has long been established as a key contributor to neuronal death. Also contributing to ischemic/reperfusion-induced neuronal death is oxidative stress, chemically defined as a pathologic state within the cell arising from the increased …
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Regulation of AMPA receptor acetylation and translation by SIRT2 and AMPK: the molecular mechanisms and implications in memory formation
… mino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are ligand-gated glutamatergic ion channels that mediate most excitatory neurotransmission in the brain. Alterations in AMPAR synaptic accumulation mediate synaptic plasticity, including long-term potentiation, long-term …
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The role of glutamate transporters and the scaffolding protein IQGAP1 in the regulation of AMPA receptor trafficking and turnover
… activity shape the synaptic localization of AMPA (a-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid)-type glutamate receptors (AMPARs), and this process is thought to underlie higher brain functions such as learning and memory. During excitatory synaptic transmission, the presynaptic …
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The Effects of Aniracetam Treatment on Cognitive Performance and AMPA Receptor GluR2 Subunit Expression After Moderate Fluid Percussion Injury in Rats
… effects by examining the expression of the AMPA receptor GluR2 subunit, the only AMPA receptor subunit that is Ca++ impermeable. Using a monoclonal antibody selective for the GluR2 subunit, immunohistochemical results indicated that injured rats treated with aniracetam (50mg/kg for 15 days …
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Insulin Modulates Synaptic Transmission and AMPA Receptor Trafficking Via Insulin Receptor Signaling Molecule In Region CA1 of the Juvenile and Mature Hippocampuss
… insulin induces synaptic plasticity in the hippocampal formation. In particular, it has been shown that insulin produces long term depression (LTD) in region CA1 of the juvenile and mature rat hippocampus. Using western blot analysis and field potential slice electrophysiology, I performed studies …
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Functional Characterization of Hippocampal Synapses in a Mouse Mutant of the Dystrobrevin Binding Protein 1 (DTNBP 1) Gene
… independent functional characterization of hippocampal synapses in sandy mice, which contain a spontaneous deletion in the DTNBP 1 gene resulting in the loss of expression of dysbindin, the protein that it encodes. I had observed enhanced excitatory basal synaptic transmission at the CA3-CA1 …
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Structural and Functional Effect of Phosphorylation On Ampa Receptors
… and Functional Effect of Phosphorylation on AMPA Receptors</h1> <p>Cailtin Edmunds show you, BA</p> <p>Advisory Professor: Vasanthi Jayaraman, Ph. D.</p> <p>The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor is the primary contributor to neuronal fast excitatory …
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Super-resolution imaging of glutamate receptors trafficking at live synapses
… from presynapse via glutamate receptors, mainly AMPA receptors and NMDA receptors. Trafficking of AMPA receptors in and out of synapses affect synaptic plasticity, which underlies the molecular mechanism of learning and memory. Lateral diffusion of AMPA receptors near synapses …
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Characterisation of leptin mimetic agents as therapeutic targets in Alzheimer's disease
… tangles. Aβ accumulation leads to hippocampal synaptic disruption and neuronal cell death. The endocrine hormone leptin, regulates food intake and body weight. However, leptin also has an important role in modulating excitatory synaptic transmission and synaptic plasticity at hippocampal …
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Investigation of the functional effects of two novel ampakines in the CNS
The ionotropic glutamate AMPA ((R,S)-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) receptor mediates the majority of excitatory transmission in the CNS. AMPA receptors play a crucial role in both basal neurotransmission and synaptic plasticity events (such as long-term potentiation, LTP). …
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