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Showing 1 to 2 of 2 for “"AMP-induced Hypometabolism"”.
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The Physiological and Biochemical Understanding of 5’-Amp Induced Deep Hypometabolism
<p>Our laboratory’s ability to induce deep hypometabolism (DH) via an injection of adenosine monophosphate (5’-AMP) followed by placement in an ambient temperature (Ta) around 15oC currently can last about 3-9 hours. While we have insight into how 5’-AMP induced hypometabolism is initiated, it …
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Influx and Efflux of Adenine Nucleotides From Erythrocytes Regulate Oxygen Transport and Systemic Metabolism
… metabolism. Our studies show that the loss of AMPD3 and CD73, two important enzymes in regulating AMP levels intra- and extra-cellularly, respectively, allows for an increase in sustained metabolic activity. We show that this increase in work capacity is linked to an increase in erythrocyte’s …