Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 51 for “"AMP-activated protein kinase (AMPK)"”.
-
The Role of Amp-Activated Protein Kinase (Ampk) In Tumorigenesis
<p>AMPK plays a central role in controlling cellular and whole body energy level. Increasing studies have also discovered the diverse function of AMPK in cancer, such as autophagy and mitochondria biogenesis. However, how AMPK promotes cancer progression is still not clear. Here, we show that AMPK …
-
AMP- Activated Protein Kinase (AMPK) Activation for the Treatment of Mitochondrial Disease
… to encode 13 electron transport chain (ETC) proteins. When mtDNA is depleted, there is a decrease in ETC activity. 5' AMP-activated protein kinase (AMPK) is a kinase that can initiate mitochondrial biogenesis and mitophagy. We hypothesized that treating cells harbouring low numbers of mtDNA …
-
AMP-ACTIVATED PROTEIN KINASE AND ITS ROLE IN THERAPEUTIC RESPONSE IN ACUTE MYELOID LEUKEMIA
… coordinate this oxidative metabolic shift is the AMP-activated protein kinase (AMPK).
-
PKA as an Upstream Kinase for LKB1/STRAD/MO25
… (LSMK) has been identified as the major upstream kinase for AMP-activated protein kinase (AMPK). PKA phosphorylates LKB1 at the Ser428 residue in humans and Ser431 residue in mice. We investigated PKA as an upstream kinase for LSMK. LKB1 that had been incubated with PKA prior to incubation with …
-
The Effects of 3-Phosphoglycerate and Other Metabolites on the Activation of AMP-Activated Protein Kinase by LKB1/STRAD/MO25
… in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase, AMPKK. The LKB1-STRAD-MO25 complex is the major AMPKK in skeletal muscle; however, LKB1-STRAD-MO25 activity is not increased by muscle contraction. This relationship suggests that …
-
Leptin Action on Dopamine Neurons: Biochemical and Behavioral Analysis
… that there are brain regions commonly activated by hedonic foods and drugs of abuse, and therefore, potentially common mechanisms underlying behaviors associated with them. Additionally, the metabolic state of an animal can affect drug seeking behavior. The discovery that leptin …
-
Regulation of LKB1-STRAD-MO25 Complex Expression and Activation of AMPK in Skeletal Muscle by Thyroid Hormone
<p>AMP-activated protein kinase (AMPK), a heterotrimeric protein which serves as a metabolic master switch in skeletal muscle, is a research target for the pharmaceutical treatment and prevention of type 2 diabetes. The expression of all of the isoforms of the subunits of AMPK and AMPK activity are …
-
DYSREGULATION OF AMP-ACTIVATED PROTEIN KINASE SIGNALING IN ALZHEIMER’S DISEASE
… pathogenic mechanism of Alzheimer’s disease. AMP-activated protein kinase (AMPK) is a master energy sensor which can sense the ratio of AMP/ATP and regulates catabolic and anabolic pathways to keep the energy metabolism in balance, and has been found to play an important role in the …
-
Regulation of Protein Degradation In The Heart By Amp-Activated Protein Kinase
<p>The degradation of proteins by the ubiquitin proteasome system is essential for cellular homeostasis in the heart. An important regulator of metabolic homeostasis is AMP-activated protein kinase (AMPK). During nutrient deprivation, AMPK is activated and intracellular proteolysis is enhanced …
-
Regulation of Protein Degradation In The Heart By Amp-Activated Protein Kinase
<p>The degradation of proteins by the ubiquitin proteasome system is essential for cellular homeostasis in the heart. An important regulator of metabolic homeostasis is AMP-activated protein kinase (AMPK). During nutrient deprivation, AMPK is activated and intracellular proteolysis is enhanced …
-
AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of sedentary and endurance trained rats
This study was designed to examine activity of AMP-activated protein kinase kinase (AMPKK) and AMP-activated protein kinase (AMPK) in muscles from control (C) and endurance trained (T) rats. Rats were trained 5 days/wk, 2 hr/d for 8 wks at a final intensity of 32 m/min up a 15% grade with 30 second …
-
Identifying Novel Functions of the WNK Pathway
… with no lysine [K] (WNK) pathway consists of WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and OSR1/SPAK substrates, cation chloride cotransporters. The pathway regulates ion transport across cell …
-
AMP-activated protein kinase-mTOR signaling pathway and hepatitis B virus replication
… B형 간염을 일으키며 만성 B형 간염 환자는 간경변이나 간암으로 발전할 가능성이 높다. AMP-activated protein kinase(AMPK)는 ATP 소비와 생성의 균형을 위해서 필요한 에너지 센서 단백질이다. Hepatitis C virus(HCV)의 증식을 위해서는 AMPK의 억제와mammalian target of rapamycin(mTOR)의 활성이 필요하며 이를 통해 바이러스 복제에 필요한 지질을 합성한다. HBV X 단백질(HBx)은 mTOR의 활성을 증가시켜 hepatocellular …
-
The heat-shock response in <i>Serpula s</i>pecies at the cellular and molecular level
… of this response is the production of heat-shock proteins (hsps). Comparative studies of chick embryo fibroblasts and <i>Saccharomyces cerevisiae</i> (wine strain, L-2226) were used to demonstrate possible differences between these three very distinct eukaryotic systems.<br/><br/>The aims of the …
-
The independent and combined effects of rapamycin and metformin on naturally occurring osteoarthritis
… target of rapamycin (mTOR) and stimulating AMP-activated protein kinase (AMPK) has extended lifespan and protected against post-traumatic (secondary) OA in mice. However, it remains unknown if manipulation of these pathways can protect against naturally occurring, age-related (primary) OA, …
-
Novel Posttranslational Modification In Lkb1 Activation and Function
… involved in metabolism is Liver Kinase B1 (LKB1). LKB1 is the major upstream kinase of the evolutionarily conserved metabolic sensor—AMP-activated protein kinase (AMPK). Activation of the LKB1/AMPK pathway provides a survival advantage for cells under energy stress. LKB1 forms a …
-
Mechanotransduction of subcellular AMPK and its role in breast cancer cell migration
… role of mechanotransduction (via Src and FAK) in AMP-activated protein kinase (AMPK) activation in breast cancer cells in response to interstitial fluid flow. Additionally, we explored the involvement of AMPK in breast cancer cell migration. An in-vitro three-dimensional (3D) cell culture model …
-
How cellular ATP/ADP ratios and reactive oxygen species affect AMPK signalling
… as a signal is by altering the activity of AMP-activated protein kinase (AMPK), a key metabolic sensor and regulator of cell metabolism, which is activated when cellular ATP levels decrease during energy demand. Mitochondria can signal to AMPK via the magnitude of the cellular ATP/AMP and …
-
A study on non-canonical autophagy signalling
… of autophagy by activating the master regulator AMP-activated protein kinase (AMPK). AMPK activates multiple downstream regulators such as ULK1, which in the canonical pathway is known to activate the VPS34 complex, resulting in the formation of PI(3)P-containing autophagosomes. A failure to …
-
NAD+ salvage by Nicotinamide phosphoribosyltransferase (Nampt) mediates lipogenesis, energy homeostasis, and survival in prostate cancer
… by Nicotinamide phosphoribosyltransferase (Nampt). In these studies, we focus on the role of Nampt in tumor biology. Specifically, we demonstrate that Nampt activity is required for <italic>de novo</italic> lipogenesis in multiple cancer cell lines. Inhibition of Nampt causes a reduction in …
Page 1 of 3