Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 4 of 4 for “"AMP-Activated Protein Kinases"”.
-
Molecular cloning of three genes encoding SNF1/AMPK protein kinases from Drosophila melanogaster.
… and the SNF1 gene, encoding a serine-threonine protein kinase, has the essential function of releasing genes from glucose repression in response to glucose starvation. SNF1 homologues have been found in a number of different organisms and recent molecular and biochemical evidence has revealed …
-
The Cancer Specific Ubiquitin Ligase MAGE-A3/6-TRIM28 Drives Tumorigenesis by Ubiquitination and Proteasomal Degradation of AMPK
… including the known tumor suppressor AMPK. Ubiquitination of AMPK by MAGE-A3/6-TRIM28 induces its proteasomal degradation, thereby enhancing mTOR signaling and inhibiting autophagy within cells. Through this modulation of AMPK, MAGE-A3/6 is also able to act as an oncogene, inducing …
-
Identifying Novel Functions of the WNK Pathway
… with no lysine [K] (WNK) pathway consists of WNK kinases, their downstream target kinases, oxidative stress responsive (OSR)1 and SPS/Ste20-related proline-alanine-rich kinase (SPAK), and OSR1/SPAK substrates, cation chloride cotransporters. The pathway regulates ion transport across cell …
-
The Transcription Factor TFEB Protects Against Cardiac Hypertrophy by Increasing Lysosomal Capacity and Activating AMPKα
… pathways associated with the lysosome, such as AMPK and mTOR, a negative and positive regulator of hypertrophy, respectively. Yet, lysosomal biogenesis and function remain poorly studied in the heart, and the possible role of the lysosome as a signaling nexus for hypertrophic stress is as yet …