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Showing 1 to 20 of 68 for “"AMP activated Protein Kinase"”.

  1. AMP-activated protein kinase and muscle metabolism

    Scheffler, Tracy L.Virginia Tech2012

    AMP-activated protein kinase (AMPK) is a major regulator of skeletal muscle metabolism with relevance to agriculture and human health. During the conversion of muscle to meat, the rate and extent of postmortem metabolism and pH decline largely determine pork quality development. Pigs with the …

    vt Repository record

  2. AMP-activated protein kinase kinase activity and phosphorylation of AMP-activated protein kinase in contracting muscle of sedentary and endurance trained rats

    Hurst, Denise2007

    This study was designed to examine activity of AMP-activated protein kinase kinase (AMPKK) and AMP-activated protein kinase (AMPK) in muscles from control (C) and endurance trained (T) rats. Rats were trained 5 days/wk, 2 hr/d for 8 wks at a final intensity of 32 m/min up a 15% grade with 30 second …

    byu Repository record

  3. DYSREGULATION OF AMP-ACTIVATED PROTEIN KINASE SIGNALING IN ALZHEIMER’S DISEASE

    Wang, XinWake Forest University2018

    … pathogenic mechanism of Alzheimer’s disease. AMP-activated protein kinase (AMPK) is a master energy sensor which can sense the ratio of AMP/ATP and regulates catabolic and anabolic pathways to keep the energy metabolism in balance, and has been found to play an important role in the …

    wfu Repository record

  4. The Role of Amp-Activated Protein Kinase (Ampk) In Tumorigenesis

    Han, Fei2017

    <p>AMPK plays a central role in controlling cellular and whole body energy level. Increasing studies have also discovered the diverse function of AMPK in cancer, such as autophagy and mitochondria biogenesis. However, how AMPK promotes cancer progression is still not clear. Here, we show that AMPK …

    uthsc Repository record

  5. Canonical and non-canonical regulation of AMP-activated protein kinase

    Auciello, Francesca RomanaUniversity of Dundee2015

    The AMP-activated protein kinase (AMPK) is a sensor of cellular energy stress that, once activated, promotes ATP-producing process while it switches off ATP-consuming pathways, in order to restore the cellular energetic balance under conditions of stress. Activation of AMPK is dependent on the …

    dundee Repository record

  6. The role of AMP-activated protein kinase in endothelial VEGF signalling

    Reihill, James AnthonyUniversity of Glasgow2009

    … type 2 diabetes and cardiovascular disease. AMPK is the downstream component of a protein kinase cascade important in the regulation of cellular and whole body metabolism. AMPK has been demonstrated to mediate a number of physiological responses in the endothelium, including the stimulation …

    glasgow Repository record

  7. AMP- Activated Protein Kinase (AMPK) Activation for the Treatment of Mitochondrial Disease

    Green, Alexander Edward2014

    … to encode 13 electron transport chain (ETC) proteins. When mtDNA is depleted, there is a decrease in ETC activity. 5' AMP-activated protein kinase (AMPK) is a kinase that can initiate mitochondrial biogenesis and mitophagy. We hypothesized that treating cells harbouring low numbers of mtDNA …

    york Repository record

  8. Regulation of Protein Degradation In The Heart By Amp-Activated Protein Kinase

    Baskin, Kedryn K2012

    <p>The degradation of proteins by the ubiquitin proteasome system is essential for cellular homeostasis in the heart. An important regulator of metabolic homeostasis is AMP-activated protein kinase (AMPK). During nutrient deprivation, AMPK is activated and intracellular proteolysis is enhanced …

    uthsc Repository record

  9. Regulation of Protein Degradation In The Heart By Amp-Activated Protein Kinase

    Baskin, Kedryn K2012

    <p>The degradation of proteins by the ubiquitin proteasome system is essential for cellular homeostasis in the heart. An important regulator of metabolic homeostasis is AMP-activated protein kinase (AMPK). During nutrient deprivation, AMPK is activated and intracellular proteolysis is enhanced …

    uthsc Repository record

  10. AMP-activated protein kinase-mTOR signaling pathway and hepatitis B virus replication

    김, 주미2015

    … B형 간염을 일으키며 만성 B형 간염 환자는 간경변이나 간암으로 발전할 가능성이 높다. AMP-activated protein kinase(AMPK)는 ATP 소비와 생성의 균형을 위해서 필요한 에너지 센서 단백질이다. Hepatitis C virus(HCV)의 증식을 위해서는 AMPK의 억제와mammalian target of rapamycin(mTOR)의 활성이 필요하며 이를 통해 바이러스 복제에 필요한 지질을 합성한다. HBV X 단백질(HBx)은 mTOR의 활성을 증가시켜 hepatocellular …

    ajou Repository record

  11. Regulation if SUR1 gene by BETA2/NeuroD and AMP-activated protein kinase

    김, 지원2011

    Master

    ajou Repository record

  12. Overcoming Tumor Drug Resistance By Activating Amp-Activated Protein Kinase And Destabilizing Oncoproteins

    Shen, Min2013

    … gene expression, at either gene transcription or protein synthesis level, can contribute to the drug-resistant phenotype. AMP-activated protein kinase (AMPK) is a well-known major cellular energy sensor, which negatively regulates metabolic pathways such as protein synthesis, fatty acid oxidation …

    wayne-thes Repository record

  13. Characterisation of the role of AMP-activated protein kinase in 3T3-L1 adipocytes

    Logan, Pamela JaneUniversity of Glasgow2009

    AMP-activated protein kinase (AMPK) has been proposed to be a therapeutic target for patients with type 2 diabetes and the metabolic syndrome. In skeletal muscle AMPK stimulates glucose uptake and fatty acid oxidation, whereas in liver it inhibits fatty acid and cholesterol synthesis. The Rab …

    glasgow Repository record

  14. AMP-ACTIVATED PROTEIN KINASE AND ITS ROLE IN THERAPEUTIC RESPONSE IN ACUTE MYELOID LEUKEMIA

    Ghiraldeli, Lais PereiraWake Forest University2018

    … coordinate this oxidative metabolic shift is the AMP-activated protein kinase (AMPK).

    wfu Repository record

  15. The effect of metformin on vascular function and AMP-activated protein kinase activation in Type 2 diabetes

    Boyle, James GrahamUniversity of Glasgow2009

    … extent of their actions remain uncertain. For example, in the United Kingdom Prospective Diabetes Study (UKPDS), metformin treatment reduced the incidence of myocardial infarction by 39% in comparison with conventional treatment which is more than would have been predicted by the difference in …

    glasgow Repository record

  16. Investigating the regulation of the PCTAIRE-1 protein kinase : a new target of AMP-activated protein kinase and beyond?

    Shehata, SaifUniversity of Dundee2012

    PCTK1 is a Cdc2-related protein kinase that is poorly characterised. Several studies have investigated its role and regulation, and have provided some insight into its upstream regulation by PKA/CDK5 phosphorylation. Proposed physiological functions include vesicle trafficking and neurite …

    dundee Repository record

  17. The Effects of 3-Phosphoglycerate and Other Metabolites on the Activation of AMP-Activated Protein Kinase by LKB1/STRAD/MO25

    Ellingson, William John2006

    … in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase, AMPKK. The LKB1-STRAD-MO25 complex is the major AMPKK in skeletal muscle; however, LKB1-STRAD-MO25 activity is not increased by muscle contraction. This relationship suggests that …

    byu Repository record

  18. Involvement of AMP-activated protein kinase in differential regulation of appetite between lines of chickens selected for low or high juvenile body weight

    Xu, PingwenVirginia Tech2011

    … weight in chickens has altered the hypothalamic AMP-activated protein kinase (AMPK) system and (2) if this alteration contributes to the dissimilar feeding response to various appetite modulators between HWS and LWS lines. Compared to HWS, LWS chickens had higher levels of AMPK α and acetyl-CoA …

    vt Repository record

  19. THE EFFECT OF AMP-ACTIVATED PROTEIN KINASE DURING HEAT STRESS ON THE INTESTINAL BARRIER AND THE REGULATION OF TIGHT JUNCTION PROTEINS OF BROILERS, RESEARCH AT SHANDONG AGRICULTURAL UNIVERSITY (CHINA)

    Uerlings, JulieULiège. GxABT - Liège Université. Gembloux Agro-Bio Tech2016

    liege Repository record

  20. PKA as an Upstream Kinase for LKB1/STRAD/MO25

    Herway, Seth Taylor2006

    … (LSMK) has been identified as the major upstream kinase for AMP-activated protein kinase (AMPK). PKA phosphorylates LKB1 at the Ser428 residue in humans and Ser431 residue in mice. We investigated PKA as an upstream kinase for LSMK. LKB1 that had been incubated with PKA prior to incubation with …

    byu Repository record

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