Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 219 for “"AML"”.
-
NOVEL RNA-BASED CANCER VACCINE FOR AML IMMUNOTHERAPY
… vaccine can be a viable treatment strategy for AML patients. Using mouse AML cell lines, we have found candidate neoepitopes within intron polyadenylation sites, retained-intron sites, and somatic mutation sites. Screen for immunogenic neoepitopes using 102 synthetic peptides was performed in …
-
Cancer treatment pathways: AML a detailed costing study example
Background: AML is one of the most common and acute diseases among the types of leukaemia. The treatment costs for AML/APML are considerably high as it involves the use of expensive treatments (such as stem cell transplantation). Over the past 20 years, the topic has attracted the interest of an …
-
Preclinical Studies of A Novel Idh1 Inhibitor In Acute Myeloid Leukemia (Aml)
… <p>Acute myeloid Leukemia (AML) is an aggressive neoplastic blood disorder characterized by proliferation of poorly differentiated cells of myeloid lineage. IDH1 is a cytoplasmic enzyme that catalyze the oxidative decarboxylation of isocitrate to α-ketoglutarate (α-KG) in the …
-
Mitochondrial Unfolded Protein Response Regulator Atf5 In Mitochondrial Targeted Therapies In Aml
… of mitochondrial stress-induced cell death in AML has not been well explored. We demonstrate that AML cells are susceptible to mitochondrial targeted agents such as ONC201, an agonist of the mitochondrial protease ClpP, and gamitrinib, an inhibitor of mitochondrial chaperone TRAP1, however, …
-
Studies on signaling pathways induced by FLT3, an important oncogene in AML
… 30% and 7% of Acute Myeloid Leukemia (AML) patients respectively, and correlate with a poor prognosis, thus making the mutated receptor a potential therapeutic target. FLT3 mutations cause constitutive activation of intrinsic tyrosine kinase of the receptor, leading to …
-
Allogeneic Double Negative T cell Therapy as a Novel Treatment for AML Patients
… an array of leukemic cell lines and primary AML cells including chemotherapy-resistant patient samples in vitro and significantly reduce the leukemia load in patient-derived xenograft (PDX) models. Unlike CD4+ and CD8+ conventional T (Tconv) cells, DNTs do not attack normal allogeneic cells …
-
Development of a mortality risk prediction score for patients with AML requiring critical care
… Though patients with acute myeloid leukemia (AML) have high mortality after intensive care unit (ICU) admission, long-term survival is possible. There is no accepted model for predicting longer-term mortality after ICU admission. We examined the role of five AML and ICU related risk factors in …
-
An Investigation into the Potential of Cell Therapies for Acute Myeloid Leukemia (AML) Treatment
… recent advances in acute myeloid leukemia (AML) treatment, curative rates remain poor with high rates of relapse and many patients are unable to tolerate the intensive chemotherapy standard of care regimen. Cell therapies have shown great success against hematologic malignancies but face …
-
Mit AML assoziierte MLL-partielle Tandemduplikationen (MLL-PTD) sind in Stammzellen aus Nabelschnurblut lebenslang nachweisbar
… Erkrankungen eingesetzt werden, auftritt. AMLs sind mit dem Auftreten genetischer Aberrationen assoziiert. Wie auch andere genetische Veränderungen, welche mit AMLs assoziiert sind, treten diese Veränderungen auch bei gesunden Individuen auf. AML, welche eine MLL-PTD aufweisen, haben eine …
-
A SEARCH FOR EPIGENETIC VULNERABILITIES OF AML CELLS PERFORMED BY A CDK INHIBITOR¿BASED CRISPR SCREENING
… Epigenetic dysregulation plays a central role in AML pathogenesis, and targeting chromatin-modifying enzymes has emerged as a promising therapeutic strategy. Among these, the histone demethylase LSD1/KDM1A has been extensively studied, yet clinical responses to LSD1 inhibition remain variable. …
-
Dissecting the early steps of MLL induced leukaemogenic transformation using a new mouse model of AML
… with simultaneous enhancement of proliferation. AML is a genetically heterogeneous disease characterized by chromosomal rearrangements that often produce fusion proteins with aberrant transcriptional regulatory activities. Among those, t(11;19) generates the MLL-ENL fusion protein, an aberrant …
-
Generation of recombinant SNAP-tag based antibody fusion proteins for immunotherapy of acute myeloid leukemia (AML)
Acute Myeloid Leukemia (AML) remains a significant challenge to cure. In Africa, Leukemia is among the ten most prevalent cancers. The lack of an updated registry, medical technologies that provide timely diagnosis, and convenient access to appropriate treatments would result in an alarming …
-
A CELL CYCLE CLOCK REGULATES THE EPIGENETIC LANDSCAPE OF AML CELLS AND DETERMINES SENSITIVITY TO LSD1 INHIBITION
Acute Myeloid Leukemia (AML) remains a complicated challenge in oncology, characterized by a complex interplay of factors that contribute to poor survival rates and resistance to chemotherapy and targeted therapies. This study presents a novel approach to unravel the layers of AML biology and …
-
Chromatin organization as a possible factor in the control of susceptibility to radiation-induced AML in mice
To view the abstract, please see the full text of the document.
-
Single Cell Proteogenomics Analysis of AML Samples Treated with Decitabine and Venetoclax Reveals Divergent Treatment Escape Mechanisms
… a standard of care for acute myeloid leukemia (AML) patients unfit for intensive chemotherapy. Nonetheless, clinical challenges persist as patients either do not respond or eventually relapse, and the underlying mechanisms of these outcomes are not yet fully understood. Prior studies have …
-
Roles of Oxidative Stress and Dna Methylation In Cigarette Smoking-Induced Accelerated Acute Myeloid Leukemia Progression
<p>Acute myeloid leukemia (AML) is a commonly diagnosed cancer in smokers. When current or former smokers have AML, they have worse survival compared to never smoking patients. This has been observed clinically for decades, but then it is unknown how smoking leads to worsened AML survival. Smoking …
-
Brüche am MLL-Gen durch apoptotische Vorgänge im Zuge von Probenalterungen im Vergleich zu Brüchen im MLL-Gen bei t-AML
Im Zuge unserer Experimente am MLL-Gen konnten wir feststellen, das Brüche am MLL-Gen nicht ausschließlich durch Exposition mit Chemo- oder Strahlentherapie entstehen, sondern auch durch andere Faktoren wie z.B. spontane Apotose durch verlängerte Lagerungszeiten möglich ist. Daher ist für wietere …
-
Oncogenic roles of RAS in acute myeloid leukemia cooperated with Mll-AF9.
… G12V ) in the context of acute myeloid leukemia (AML). We transplanted AML, which was developed in Vav-tTA TRE-NRASG12V ; Mll-AF9 transgenic ( TRM -transgenic) mice, into recipient SCID mice. Conditional repression of NRAS G12V expression greatly reduced peripheral white blood cell (WBC) counts in …
Page 1 of 11