Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"AMIDOTRANSFERASE"”.
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Glutamine Phosphoribosyl Pyrophosphate Amidotransferase From Bacillus Subtilis
Made available in DSpace on 2014-12-14T04:27:47Z (GMT). No. of bitstreams: 1 7913663.pdf: 4656709 bytes, checksum: 461aee54ab59f2ed0c2e40bce3810c47 (MD5) Previous issue date: 1978
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Purification of formylglycinamide ribotide amidotransferase from chicken liver.
Thesis: M.S., Massachusetts Institute of Technology, Department of Biology, 1964
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Inactivation of Glutamine Phosphoribosyl Pyrophosphate Amidotransferase in Bacillus Subtilis
Made available in DSpace on 2014-12-14T04:27:33Z (GMT). No. of bitstreams: 1 7524417.pdf: 4422518 bytes, checksum: 2fcd34aaf1e4447b579382dfd2fa4456 (MD5) Previous issue date: 1975
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Glutamine Phosphoribosyl Pyrophosphate Amidotransferase From Bacillus Subtilis: Iron-Sulfur Biochemistry and Enzymology
… iron-sulfur prosthetic group of glutamine PRPP amidotransferase was found to be a {4Fe-4S} cluster. In the native enzyme, the cluster exists in the diamagnetic +2 redox state. Treatment of the cluster with oxidants resulted either in no reaction or in oxidative dissolution of the cluster, i.e., …
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Enzymatic Characterization Of The Ammonia Tunnel In Helicobacter Pylori Asp-Trnaasn/glu-Trnagln Amidotransferase
… Asp-tRNA<sup>Asn</sup>/Glu-tRNA<sup>Gln</sup> amidotransferase (AdT) plays important roles in indirect aminoacylation and translational fidelity; however, its inter-domain communication and ammonia delivery mechanisms are not well understood. In the present study, we investigated the three …
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Chemistry and Regulation of the Oxygen-Dependent Inactivation of Glutamine Phosphoribosyl Pyrophosphate Amidotransferase From Bacillus Subtilis
… of Bacillus subtilis glutamine P-Rib-PP amidotransferase in vitro and in vivo. A detailed description of the physical and chemical changes occurring in purified amidotransferase has been obtained. Inactivation of the enzyme by oxygen results in oxidation of the essential Fe-S cluster of …
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Mechanistic studies on de novo purine biosynthesis : probing for intermediates of AIR synthetase, FGAR amidotransferase and AIR carboxylase
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1994.
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Channeling in purine biosynthesis : efforts to detect interactions between PurF and PurD and characterization of the FGAR-AT complex
… reported between phosphoribosylpyrophosphate amidotransferase (PurF) and glycinamide ribonucleotide synthetase (PurD), no evidence for a PurF:PurD complex has been found. In an effort to detect this complex, stopped-flow fluorescence spectroscopy was used to detect changes in PurF fluorescence …
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Participation of the iron-sulfur cluster of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase in the inactivation and degradation of the enzyme in vivo
Bacillus subtilis glutamine P-Rib-PP amidotransferase contains a (4Fe-4S) cluster which is essential for activity. The enzyme also undergoes removal of 11 N-terminal residues from the primary translation product in vivo to form the active enzyme. It has been proposed that oxidative inactivation of …
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Inhibitor studies on para-aminobenzoic acid synthase.
… and antibiotic development. A glutamine amidotransferase and ADC synthase form a heterodimeric complex and carry out the amino substitution reaction to yield 4-amino-4-deoxychorismate (ADC). A separate subunit, ADC lyase, then carries out the elimination of pyruvate to yield P ABA. My …
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Genetic studies on the region downstream of the unc operon of Thiobacillus ferroxidans
… as the T ferrooxidans glmS gene encoding the amidotransferase, glucosamine synthetase (EC 2.6.1.16). The third open reading frame (ORF3) was found to have very good amino acid sequence homology to TnsA of transposon Tn7. Inverted repeats very similar to the imperfect inverted repeat sequences …
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Oxidativer Stress- assoziierter neuronaler Zelltod und die Identifikation neuroprotektiver Gene durch ein neuartiges Screening-System
… Nrf2 und das Enzym Glutamin: Fruktose-6-phosphat Amidotransferase-2 (Gfat-2) detektiert werden. Nrf2 aktiviert die Transkription sog. „antioxidant response element (ARE)“-regulierter Antioxidanzien und detoxifizierender Enzyme, und wirkt somit indirekt schützend. Für Gfat-2 war bisher noch kein …
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Assembly And Function Of Macromolecular Complexes For Accurate Trna Aminoacylation In Helicobacter Pylori
… by Asp–tRNA<sup>Asn</sup>/Glu–tRNA<sup>Gln</sup> amidotransferase (Asp/Glu–AdT) to produce Asn–tRNA<sup>Asn</sup>. Gln–tRNA<sup>Gln</sup> is produced vial an analogous process, relying on a misacylating glutamyl tRNA synthetase, GluRS2 and AdT.</p> <p>Including <i>H. pylori</i>, organisms that …
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CHEMOENZYMATIC APPROACHES TO THE PREPARATION OF BIOLOGICALLY ACTIVE COMPOUNDS
… amides were tested as inhibitors for amidotransferase, an enzyme absent in humans and present in some archea, organella and bacterials, and then an ideal target for new antibacterial compounds.
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Structural And Functional Characterization Of Proteins Of Unknown Function (hp0495, Hp0100 And Hp1259) In Helicobacter Pylori
… Next, the heterotrimeric, glutamine-dependent amidotransferase (called AdT or GatCAB) converts the misacylated Asp-tRNAAsn into Asn-tRNAAsn. A parallel pathway exists for the synthesis of Gln-tRNAGln, wherein misacylation of tRNAGln with glutamate is catalyzed by a tRNAGln-specific …