Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"AMD3100"”.
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Modulation of the tumor microenvironment by the CXCR4 antagonist AMD3100 in pancreatic and colorectal adenocarcinoma
… cells. Targeting the CXCL12/CXCR4 pathway with AMD3100, a CXCR4 antagonist, resulted T cell infiltration and tumor regression with anti-PD-L1 therapy in the KPC model. The CAMPLEX clinical trial was initiated to assess the safety of a 7-day AMD3100 infusion and provide proof-of-concept that …
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Antivirale Wirksamkeit des Chemokinrezeptorhemmstoffs 1,1’-bis-1,4,8,11-tetra-azazyklo-tetradekan bei Katzen mit feliner Immunschwächevirusinfektion
… 1,1’-bis-1,4,8,11-tetraazacyclotetradekan (AMD3100)“ Antiretroviral efficacy of the bicyclam 1,1’-bis-1,4,8,11-tetraazacyclotetradekan (AMD3100) alone or in combination with the acyclic nucleoside phosphonate (R)-9-(2-phosphonylmethoxyethyl)adenine (PMEA) was investigated. Forty naturally …
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CXCL12/CXCR4 signaling in mesocorticolimbic reward pathways: relevance to cocaine reinforcement and relapse
… activity using a selective CXCR4 antagonist AMD3100. Results demonstrated that AMD3100 (5, 10 mg/kg, IP) pretreatment dose-dependently attenuated cocaine-induced locomotor activity without affecting the baseline activity. Thereafter, effects of AMD3100 on cocaine’s reinforcing efficacy were …
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Stromal Derived Growth Factor Alpha (Sdf-1Α) Induces The Differentiation of Bone Marrow Progenitor Cells (Bmcs) Into Pericytes By Regulating Platelet Derived Growth Factor B (Pdgf-B) Transcription
… tumor-bearing mice with the SDF-1α antagonist, AMD3100 and found that inhibiting SDF-1α signaling in the tumor microenvironment decreased the tumor microvessel density, decreased the tumor blood vessel perfusion and, increased tumor cell apoptosis. We then analyzed the effect of AMD3100 on …
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Evaluation of new PET tracers for receptor tumour imaging
… in comparison with the clinically approved AMD3100 and related compound AMD3465. [64Cu]CuCB-Bicyclam was shown to bind specifically and with high affinity to CXCR4. The in vivo PET/CT imaging showed that [64Cu]CuCB-Bicyclam has excellent characteristics for imaging CXCR4 and is able to …
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Mobilisation, Isolation and Coculture of Haematopoietic Stem Cells
… has already been demonstrated that the bicyclam AMD3100, a CXCR4 antagonist, in combination with G-CSF is able to induce a significant mobilization of CD34+ cells4. And human placenta is a potent hematopoietic niche containing hematopoietic stem and progenitor cells throughout development5. The …
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Synthesis of Macrocyclic Polyamines and their Cu, Fe, Mn and Zn Complexes Targeting HIV (AIDS).
… cyclotriazadisulfonamide (CADA) and bicyclam AMD3100 act as entry inhibitors against HIV by different mechanisms. The manganese complex of pyridine-fused macrocyclic polyamine (M40401) has been found to reduce HIV-1 induced apoptosis of astroglial cells. Based on these findings, seventeen new …
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THE ROLE OF SDF-1[alpha] AS A VASCULOGENIC CHEMOKINE AND ENDOTHELIUM-ASSOCIATED CELL ADHESION MOLECULE FOR THE RECRUITMENT OF BONE MARROW-DERIVED PROGENITOR CELLS TO DEVELOPING TUMORS
… with anti-CXCR4 antibody or the CXCR4 antagonist AMD3100 decreased adhesion of LSK cells by 50%. Biolocalization of adoptively-transferred EGFP-Lineage-negative BMC in tumor-bearing wild-type mice was evaluated by qPCR for the egfp-transgene. A significantly greater number of Lineage-negative BMC …