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Showing 1 to 3 of 3 for “"AM404"”.
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The role of the periaqueductal gray in modulation of acute and chronic pain: Actions of drugs with analgesic properties on periaqueductal gray neuronal network
… indicate that focal bilateral microinjection of AM404, an AEA uptake inhibitor, into the PAG induced analgesia to noxious thermal stimuli (radiant heat) both in normal and paclitaxel-treated (2 mg/kg i.p. for 4 alternate days). This analgesia was mainly mediated by both CB1 and TRPV1 receptors in …
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Eficacia antiparkinsoniana de ligandos cannabinoides del receptor CB1 en un modelo animal de la enfermedad de Parkinson
… de un agonista cannabinoide CB1, el AM404, junto a su interacción con receptores dopaminérgicos y serotoninérgicos en el estriado. Para ello se ha utilizado el modelo de Parkinson de la 6-OHDA en ratas. Además se han estudiado 2 variables en este modelo: la existencia de correlación …
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Bioactive Lipids in Nociception
… metabolite, to form the potent TRPV1 activator AM404 in the central nervous system. We show that acetaminophen is able to reduce the content of prostanoids in brain and kidney, but this effect is independent of FAAH. While ibuprofen produces a similar reduction as acetaminophen of the PGE2 level …