Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"AM251"”.
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Studies investigating the mechanisms of the cardioprotective effects of Cannabidiol.
… which can be dose-dependently inhibited by AM251; secondly, both CBD and AM251 alone (a CB1 receptor antagonist and GPR55 agonist) can induce vasodepressor responses and finally, CBD can potentiate the AM251-mediated hypotension when co-administered, suggesting possible cross-talk between …
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Studies on transient receptor potential vanilloid subtype 1 (TRPV1)-mediated degeneration of mesencephalic cellsin vivo and in vitro
… which were inhibited by CZP, the CB1 antagonist AM251 or the intracellular Ca2+ chelator BAPTA/AM. We also found that CAP or AEA increased mitochondrial cytochrome c release as well as immunoreactivity to cleaved caspase-3, and that the caspase-3 inhibitor z-DEVD-fmk protected DA neurons from …
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Seizures Cause Long-Lasting Analgesia and Short-Lasting Hyperoxia
… inhibitor (SC560) and a CB1 receptor antagonist (AM251) on postictal oxygen levels in the same region through the same oxygen-recording procedure, with the addition of administration of one of said drugs prior to seizure elicitation. Results: A single maximal electroconvulsive stimulation-induced …
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The endocannabinoid system in critical neurodevelopmental periods: Focus on its role in the pathophysiology of schizophrenia as neurodevelopmental disorder [Il sistema endocannabinoide nei periodi critici del neurosviluppo: Focus sul suo ruolo nella fisiopatologia della schizofrenia come disturbo dello neurosviluppo]
… precoce con antagonista/agonista inverso CB1-AM251 [dal giorno post-natale (PND) 2-PND 8, 0,5 mg/kg/die, i.p.] (ratti di sesso maschile); Modelli animali per gli esperimenti condotti durante il periodo adolescenziale: Modello di esposizione adolescenziale al THC (PND 29-PND 39, dosi crescenti …
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Eficacia antiparkinsoniana de ligandos cannabinoides del receptor CB1 en un modelo animal de la enfermedad de Parkinson
… cannabinoides del receptor CB1, SR141716A y AM251, y su interacción con receptores dopaminérgicos a nivel estriatal, y valorar la eficacia antiparkinsoniana de un agonista cannabinoide CB1, el AM404, junto a su interacción con receptores dopaminérgicos y serotoninérgicos en el estriado. Para …
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Novel roles of the endocannabinoid system in modulating synaptic plasticity
… is completely abolished by the CB1 antagonists AM251 and SR141716. Unlike theta burst stimulation (TBS) induced LTP, 10 Hz LTP does not require NMDA receptor activation. However, it is prevented when both NMDA and group1 mGluR receptors are blocked. The 10 Hz LTP is also independent of GABAergic …
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Novel roles of the endocannabinoid system in modulating synaptic plasticity
… is completely abolished by the CB1 antagonists AM251 and SR141716. Unlike theta burst stimulation (TBS) induced LTP, 10 Hz LTP does not require NMDA receptor activation. However, it is prevented when both NMDA and group1 mGluR receptors are blocked. The 10 Hz LTP is also independent of GABAergic …
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Novel Insights into CB1 Receptor Signaling and the Anabolic Role of Cannabinoid Receptors in Bone
… MC3T3-E1 osteoblastic cells, the CB1 antagonist, AM251, has been reported to induce increases in Runx2 mRNA, mineralized bone nodule formation, and activation of signaling molecules such as ERK and AKT (Wu et al., 2011). Studies from our lab characterizing mice in which both CB1 and CB2 receptors …
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Dopamine Modulates Corticostriatal Inputs During Motor Command Signalilng
… of L-DOPA with the CB1 receptor antagonist, AM251, completely normalized motor function. This treatment regime also completely normalized basal corticostriatal activity on the lesioned hemisphere, and the D2 receptor "filtering" effect was restored. Our findings confirm that dopamine …
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The role of the periaqueductal gray in modulation of acute and chronic pain: Actions of drugs with analgesic properties on periaqueductal gray neuronal network
… by pre-treatment with CB1 receptor antagonist (AM251) suggesting a crucial role of CB1 receptor in AM404 mediated analgesic effects. These findings suggest that paclitaxel treatment could lead to plasticity in the PAG that might contribute to generation and maintenance of neuropathic pain. These …