Global ETD Search
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Showing 1 to 20 of 109 for “"ALPHA-SYNUCLEIN"”.
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Alpha Synuclein Oligomers in Human Pathology: Significance of Nitrative Alpha Synuclein Modifications
… aggregates of αSyn is a pathological hallmark of synucleinopathies such as Parkinson disease (PD) and dementia with Lewy bodies (DLB), which are clinically characterized by motor and cognitive dysfunction. Recent evidence indicates that αSyn oligomer intermediates are the most neurotoxic species. …
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Metabolism of Alpha-Synuclein by the 20S Proteasome
… aggregation of the neuronal protein alpha-synuclein (alphaSyn) that normally associates with synaptic vesicles. Within the aggregates, a fraction of alphaSyn is truncated at the C-termini, and these truncations are hypothesized to participate in disease pathogenesis. The prevailing …
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Aggregation of alpha-synuclein using single-molecule spectroscopy
The aggregation of alpha-synuclein (αS) protein from soluble monomer into solid amyloid fibrils in the brain is associated with a range of devastating neurodegenerative disorders such as Parkinson’s disease. Soluble oligomers formed during the aggregation process are highly neurotoxic and are …
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Effects of Aggregated Alpha-Synuclein on Cultured Neuronal Cells
<p>α-synuclein dysregulation is a critical aspect of Parkinson's disease pathology. Recent studies have observed that α-synuclein aggregates are cytotoxic to cells in culture and that this toxicity can be spread between cells. However, the molecular mechanisms governing this cytotoxicity and spread …
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Plasma alpha synuclein assay in Parkinson's disease and parkinsonisms
E' stato condotto uno studio osservazionale trasversale caso controllo finalizzato al dosaggio plasmatico della alfa sinucleina nella malattia di Parkinson e in soggetti sani di controllo. La alfa sinucleina decrementa nei maschi ma non nelle donne al progredire della malattia. Inoltre solo negli …
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Targeting and Localization of Alpha-Synuclein in Primary Neurons
… dysfunction and aberrant accumulation of alpha-synuclein (alpha-syn) has been linked to neurodegenerative conditions such as Parkinson's disease (PD) and dementia with Lewy bodies. Previous studies have shown that alpha-syn normally undergoes delayed localization to presynaptic terminals …
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The prion-like properties of assembled human alpha-synuclein
… inclusions in nerve cells and glial cells. Alpha-synuclein is the main component of the inclusions of Parkinson’s disease, dementia with Lewy bodies and multiple system atrophy, as well as of rarer diseases, collectively called synucleinopathies. For a long time, it was widely believed that …
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Investigating in vitro Alpha-Synuclein Aggregation of Parkinson's Disease
… component of Lewy pathology is aggregated α-synuclein (α-syn), particularly involving phosphorylated forms at Serine 129. In familial PD cases, mutations in the SNCA gene encoding α-syn are involved. Despite being recognised as a key neuropathological characteristic, the role of α-syn remains …
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Rational Design of Antibodies against Tau and Alpha-Synuclein
… proteins such as amyloid beta (Abeta), tau, and alpha-synuclein (aSyn). Although these protein deposits correlate to some extend with disease progression and cognitive decline, increasing evidence suggests that small intermediate aggregate species called oligomers are the primary driver of …
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Methionine Sulfoxide Reductase and Ubiquitin-dependent Degradation of Alpha-synuclein
Alpha-synuclein (αSyn) is one of the key proteins considered to be involved in the pathogenesis of the Parkinson`s disease (PD) and being the main component of Lewy bodies (LBs). Studies on the αSyn gene mutants and overexpression of αSyn in yeast and rodent brains indicate that the level of αSyn …
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Solid-State Nuclear Magnetic Resonance Spectroscopy of Alpha-Synuclein Fibrils
… solving 3D structures of amyloid fibrils. Alpha-synuclein is a 140-residue protein that has been implicated in Parkinson's disease. Fibrils of alpha-synuclein are the primary fibrillar component of Lewy bodies, which are the pathological hallmark of the disease; however, the role that …
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Modeling intrinsically disordered proteins ; a comprehensive study of [alpha]-synuclein
… substantia nigra. Several studies suggest that a-synuclein, the major component of these intracellular inclusions, plays a major role in the neurodegenerative process. Therefore understanding the structural properties of [alpha]-synuclein and its aggregation mechanism is of particular interest. …
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Interaction of alpha-synuclein with nanoscale systems that mimic synaptic vesicles
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2025-08-01
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Structural Polymorphism of Alpha-Synuclein in Conditions Resembling the Cellular Environment
… the aggregation of a small presynaptic protein, alpha-synuclein (aSyn), from its functional disordered form into amyloid fibrils with characteristic β-sheet structure, as being at the centre of PD. However, many unanswered questions remain with regards to the aSyn aggregation mechanism in neurons …
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Linking the structure of alpha-synuclein oligmers to function in Parkinson's disease.
Misfolding and aggregation of alpha-synuclein (a-syn) are associated with a range of neurological disorders, including Parkinson's disease (PD). Fibrillar, insoluble aggregates of a-syn, known as Lewy bodies (LBs) are deposited in the substantia nigra and are a pathological hallmark of PD. a-syn is …
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alpha-Synuclein: Synaptische Funktion und Rolle bei der Pathogenese der Parkinson-Syndrome
Die Synuclein-Proteinfamilie besteht aus den vier Paralogen a-, b-, g-Synuclein und Synoretin. a- und b-Synuclein werden hauptsächlich im Gehirn, g-Synuclein im peripheren Nervensystem und Synoretin in der Retina exprimiert. Subzelluläre Fraktionierungen und immunzytochemische Untersuchungen …
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Regulation of Weibel-Palade Body Exocytosis by alpha-Synuclein in Endothelial Cells
a-Synuclein (a-syn) is a small presynaptic protein implicated in the pathogenesis of Parkinson’s disease. Although gathering evidence has been proposed for its physiological roles, the precise roles of a-synuclein and mechanisms remain incompletely understood. a-Synuclein is not only expressed in …
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Interactions of Alpha-Synuclein With Phospholipids: Implications for Physiology and Neurodegenerative Disease
… (reviewed here), this work suggests that synuclein's membrane-based interaction with long-chain polyunsaturated phospholipids may be physiologically relevant to synaptic function, and further, may represent an early event in the development of neurodegenerative disease.
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INVESTIGATION OF ALPHA-SYNUCLEIN/TUBULIN INTERACTION IN PRESYNAPTIC MICROTUBULE DYNAMICS IN DOPAMINERGIC NEURONS
… disease (PD) are still unknown. Among them, α-synuclein aggregation, mitochondrial impairment, increase oxidative stress and synaptic dysfunction are often indicated as culprits, although it is unclear whether these events are primary or secondary insults in PD neurodegeneration. Unlike other …
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Drp1 inhibition is protective against mitochondrial and autophagic impairment induced by alpha-synuclein
… or neurorestorative treatments available. Alpha-synuclein (α-syn) pathology is one of the key proteins involved in PD pathology, it has been found to induce mitochondrial dysfunction, yet the mechanism is not entirely understood. This thesis project tests the hypothesis that α-syn induces …
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