Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"ALLERGIC AIRWAY INFLAMMATION"”.
-
New Mediators and Novel Mechanisms in Allergic Airway Inflammation
Hyperresponsiveness and inflammation are major pathophysiological features of both allergic rhinitis and asthma. The mechanisms behind these are not fully understood. The aims of this thesis were to investigate if cytokines involved in the allergic response can induce airway hyperreactivity by …
-
Remodeling of the pulmonary circulation - a novel response to allergic airway inflammation
Asthma is characterized, not only by inflammation but also by airway and vascular remodeling. Airway remodeling is established early in disease, structural alterations have been found in children, and is thought to contribute to asthma symptoms. Unfortunately, airway remodeling is considered …
-
TREM-2 and Dendritic Cells in the Pathogenesis of Allergic Airway Inflammation
Asthma is a chronic disorder of the conducting airways that involves the interplay of multiple genetic and environmental factors. It is characterized by reversible airway obstruction, cellular infiltration, airway inflammation and airway remodeling. Dendritic cells (DCs) are professional antigen …
-
Analysis of Immunomodulatory Effects of Vitamin D in Epithelial-Mesenchymal Transition and Airway Remodeling in Allergic Airway Inflammation.
… asthma, a chronic inflammatory disease of the airways, show pathological changes in the airways, including airway remodeling, basement membrane thickening, and epithelial damage with large immune cell infiltrate. How the epithelium contributes to airway remodeling and subepithelial fibrosis is …
-
THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA
Allergic asthma is a chronic inflammatory disease that affects approximately 300 million people worldwide. The health problem is compounded by the fact that the prevalence of the disease is increasing in the Western world. Thus, there is a continued need for new and improved therapies for the …
-
THE EFFECT OF A CANNABINOID RECEPTOR 2 (CB2) AGONIST ON ALLERGIC AIRWAY INFLAMMATION IN A MOUSE MODEL OF ASTHMA
Allergic asthma is a chronic inflammatory disease that affects approximately 300 million people worldwide. The health problem is compounded by the fact that the prevalence of the disease is increasing in the Western world. Thus, there is a continued need for new and improved therapies for the …
-
The temporal requirement of IL-4Rα signalling in allergic asthma and the role of IL-4Rα-responsive Regulatory T cells in restraining allergic airway inflammation
Allergic asthma is a chronic inflammatory airway disease driven predominantly by a TH2 immune response to environmental allergens. The asthma pathology is predominantly elicited by IL-4 and IL-13 signalling via IL-4Rα-signalling which is essential for driving TH2-type immunity to allergens. …
-
The relationship between pesticide metabolites and asthma outcomes among women farm workers
… a limited number have explored mechanisms for allergic and non-allergic airway inflammation in individuals exposed to pesticides. A previous sub-study of this group reported an association between allergic airway inflammation as determined by fractional exhaled nitric oxide (FeNO) and low …
-
Implicación de igf1r en inflamación pulmonar aguda y en alergia inducida por ácaros del polvo doméstico en ratones
… COPD, pulmonary fibrosis and asthma, in which inflammation is a relevant component. Methods: Igf1r deficiency was induced in four-week-old UBC-CreERT2; Igf1rfl/fl mice by five consecutive intraperitoneal tamoxifen (TMX) injections to generate UBC-CreERT2; Igf1rΔ/Δ (CreERT2) mice. Then, …
-
Vitamin D and Immunomodulation in Bronchial Asthma
… most common chronic inflammatory diseases of the airways. The chronic inflammation is associated with airway hyperresponsiveness (AHR), airway obstruction and airway remodeling. In asthmatics the airway epithelium produces increased amounts of proinflammatory cytokines including TNF-α (Tumour …
-
A mouse model of childhood asthma: mechanisms of development and progression following an early-life respiratory viral infection
… (RSV), are strongly linked to development of allergic asthma. The aim of this project was to develop a mouse model of the induction phase of childhood asthma, to facilitate investigation of the interaction of early-life infection with RSV, subsequent allergen exposure and development of …
-
Posttranscriptional gene regulation of CD4+ T cell cytokine expression by the RNA binding protein HuR
… and defects in Th2 cytokine production. In an allergic airway inflammatory model, OVA-challenged HuR KO mice had decreased lung cellular infiltration, eosinophilia and IL-13. These results demonstrate that HuR plays a pivotal role in maintaining normal IL-2 homeostasis, augmenting Th2 …
-
Functional Responses of Lung Dendritic Cell Subsets in Flt3 Ligand-Induced Immunomodulation in Allergic Asthma
Asthma is an inflammatory airway disease characterized by airway eosinophilia, airway obstruction due to an increased mucus production by goblet cells, airway remodeling, and airway hyperresponsiveness (AHR) to a variety of stimuli. In allergic airway inflammation, dendritic cells (DC) deliver …
-
Immune activation at the lung epithelial barrier
… immune responses resulted in reduced features of allergic airway inflammation. Recent studies revealed an important role for structural cells, especially epithelial cells, in allergic asthma. Lung epithelial cells express pattern recognition receptors (such as TLR4) and respond to allergens by …
-
Respiratory allergy and asthma associated with pesticide exposure amongst women in rural Western Cape
… asthma, adult onset asthma, current asthma, allergic sensitisation, allergic airway inflammation and the asthma symptom score. The asthma symptom score was a continuous outcome generated as the sum of positive responses to four questions on asthma symptoms in the last 12 months including …
-
Functional characterisation of novel mast cell genes
… in models of delayed-type hypersensitivity and allergic airway inflammation. In addition to these findings, and given that the physiological role of Gem was not yet understood prior to our study, we extended our investigation to explore a potential function for Gem in the metabolic system. Using …
-
Immunopathological and Structural Alterations in Difficult to Control Asthma
… and IV, respectively). In Paper I, we show that allergic airway inflammation extends to the peripheral airways specifically in patients that are poorly controlled. This suggests that targeting peripheral airway inflammation, for example with extrafine-particle formulations of inhaled …
-
The study of occupational risk factors and interventions for baker's allergy and asthma among supermarket bakery workers
… by IgE-mediated sensitisation and subsequent allergic reaction in the airways to specific occupational airborne allergens in flour or baking ingredients. Major aims of this study were to: characterise asthma phenotypes and environmental exposure to flour allergens among bakers and modifying …
-
Investigation of immune responses in different mouse models of allergic asthma
… Understanding the immune responses during allergic diseases is essential for both diagnosis and the development of effective therapies. The route of sensitisation to allergens is one factor that influences the immune response and the outcome of allergic diseases and both human and animal …
-
T-Regulatory Cells and FLT3-Ligand in the Therapy of Cockroach Antigen-induced Asthma
Asthma is a chronic disease of the airways, characterized by airway hyper-responsiveness (AHR) and airway inflammation. Many inflammatory cells, including mast cells, eosinophils, neutrophils, and lymphocytes, are critical in the initiation of the pathophysiological changes in asthma. The …