Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"ALK2"”.
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Identification and Optimization of Small Molecule Binders for ALK2, USP5, and DCAF1
… various cancers: Activin receptor-like kinase 2 (ALK2), ubiquitin-specific protease 5 (USP5), and DDB1-cullin4 associated factor 1 (DCAF1). For ALK2, a kinase involved in the development of diffuse intrinsic pontine glioma, we report the design, synthesis, and evaluation of a first-in-class set of …
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Development of BMP type I receptor kinase inhibitors for the treatment of fibrodysplasia ossificans progressiva and the study of the BMP signaling pathway
… the BMP type I receptor activin-like kinase 2 (ALK2), characterized by the progressive heterotopic ossification (HO) of skeletal muscle and connective tissue leading to widespread joint immobilization, with significant morbidity and premature mortality. There are currently no effective …
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Molecular insights into signalling mechanisms within TGF-β superfamily
… I demonstrated that the transmembrane helices of ALK2 and ALK4 receptors homodimerize and designed a novel bacterial signalling assay that can test for transmembrane helix heterodimerisation that overcomes problems with existing similar assays. Overall, I have demonstrated that structural …
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Andstæð hlutverk TGF-ß fjölskyldunnar í fylgjumyndun og meðgöngueitrun
… sýndu að í næriþekjufrumum ýtti BMP9/ALK2/SMAD1/5 boðleiðin undir tjáningu ANGPTL4 sem jók frumuskrið. ANGPTL4 hafði neikvæð áhrif á viðloðun æðaþels HUVEC frumna. Í meðgöngueitrun dró úr tjáningu ANGPTL4 í fylgju miðað við í eðlilegri meðgöngu. TGF- ß/ALK5/SMAD2/3 boðleiðin ýtti undir …