Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"ALK1"”.
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N-linked glycosylation at position ASN98 of the ALK1 receptor protein: relevance for ALK1 function and HHT pathogenesis
… endoglin and activin receptor-like kinase 1 (ALK1). These mutations result in development of HHT Type 1 and HHT Type 2, respectively. Patients suffering from HHT experience spontaneous blood vessel growth that can lead to telangiectasia, arteriovenous malformation (AVM) development, and other …
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The Role of Type III Transforming Growth Factor-β Receptor in Regulating ALK1 Signaling and Endothelial Biology
… or mutation of Activin receptor-Like Kinase 1 (ALK1), an endothelium- specific TGF-β superfamily receptor kinase, leads to disordered angiogenesis and results in the hereditary vascular disease, Hereditary Hemorrhagic Telangiectasia (HHT). A co-receptor in the TGF-β superfamily, the type III …
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Targeting Organic Anion Transporting Polypeptide 1A4 (Oatp1a4) for Effective Drug Delivery at the Blood-Brain Barrier
… activation of activin receptor-like kinase 1 (ALK1), a critical component of the transforming growth factor-β (TGF-β) pathway, using the selective agonist Bone Morphogenetic Protein (BMP)-9 increases Oatp1a4 protein expression in rat brain microvessels in vivo. Additionally, we demonstrate that …
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Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… PASMCs and HPAECs is mediated through the BMPRII-ALK1-BclxL axis. Finally, the siRNA screen targeting approximately 1000 genes has identified novel proteins including PPP1CA, IGF-1R, MPP1, MCM5 and SRC each capable of modulating the BMPRII signalling. Taken together, this study for the very first …
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Role of plasma membrane ATPase4 in the pathophysiology of pulmonary arterial hypertension
… expression of PAH-associated receptors (BMPR2, ALK1, TGFβR1, Endoglin) was evaluated in lung RNA from PMCA4 wild-type and knockout mice by qPCR, showing no significant differences. In vitro, stimulation of human PAECs and HUVECs with TNF-α and cycloheximide (CHX) significantly reduced PMCA4 mRNA …
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Investigation of the therapeutic potential of recombinant BMP10 in an adult mouse model of HHT1 and the crosstalk between BMP and VEGF signalling
… in the Eng-iKOe lungs. Additionally, reduced Alk1 and Bmpr2 mRNA expression was fully rescued after pBMP10 treatment. In the in vitro analysis of human endothelial cells, BMP and VEGF ligands modulated common target genes such as FOS, ESM1, PlGF, and ET1, they will be further investigated in …
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Bone morphogenetic proteins 9 & 10 in pulmonary arterial hypertension
… PAH. BMPR-II forms a signalling complex, with ALK1 and endoglin, specific to endothelial cells which maintains vascular quiescence. BMP9 and BMP10 are the high affinity ligands for this signalling complex. Administering exogenous BMP9 has been shown to reverse disease in animal models of PAH, …