Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"ALK1"”.
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N-linked glycosylation at position ASN98 of the ALK1 receptor protein: relevance for ALK1 function and HHT pathogenesis
… endoglin and activin receptor-like kinase 1 (ALK1). These mutations result in development of HHT Type 1 and HHT Type 2, respectively. Patients suffering from HHT experience spontaneous blood vessel growth that can lead to telangiectasia, arteriovenous malformation (AVM) development, and other …
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The Role of Type III Transforming Growth Factor-β Receptor in Regulating ALK1 Signaling and Endothelial Biology
… or mutation of Activin receptor-Like Kinase 1 (ALK1), an endothelium- specific TGF-β superfamily receptor kinase, leads to disordered angiogenesis and results in the hereditary vascular disease, Hereditary Hemorrhagic Telangiectasia (HHT). A co-receptor in the TGF-β superfamily, the type III …
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Targeting Organic Anion Transporting Polypeptide 1A4 (Oatp1a4) for Effective Drug Delivery at the Blood-Brain Barrier
… activation of activin receptor-like kinase 1 (ALK1), a critical component of the transforming growth factor-β (TGF-β) pathway, using the selective agonist Bone Morphogenetic Protein (BMP)-9 increases Oatp1a4 protein expression in rat brain microvessels in vivo. Additionally, we demonstrate that …
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TGF-beta,Smad signaling in hepatic stellate cells and during liver fibrogenesis
… which was dependent on activation of the novel ALK1/Smad1/5/8 pathway. Knocking-down expression of ALK1 in HSC interfered with TGF-beta dependent Smad1 phosphorylation and Id1 upregulation, but did not block the activation of the Smad2/3 pathway. In summary, gene transfer of Smad7 inhibits …
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Einfluss von BMP-7 und Endoglin auf den TGF-beta Signalweg bei fibrosierenden Lebererkrankungen
… ALK-2, ALK-3 and ALK-6, while TGF-b activates ALK1 and ALK5. As a consequence of activation of the ALK5/Smad3 pathway the Collagen I expression is induced and as a consequence of the ALK1/Smad1/5 pathway a transient expression of Id-1 is induced. The BMP-7 signal is exclusively mediated through …
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Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… PASMCs and HPAECs is mediated through the BMPRII-ALK1-BclxL axis. Finally, the siRNA screen targeting approximately 1000 genes has identified novel proteins including PPP1CA, IGF-1R, MPP1, MCM5 and SRC each capable of modulating the BMPRII signalling. Taken together, this study for the very first …
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Therapeutic Targeting of BMP and TGF-β Signalling Pathways for the Resolution of Pulmonary Arterial Hypertension
… PASMCs and HPAECs is mediated through the BMPRII-ALK1-BclxL axis. Finally, the siRNA screen targeting approximately 1000 genes has identified novel proteins including PPP1CA, IGF-1R, MPP1, MCM5 and SRC each capable of modulating the BMPRII signalling. Taken together, this study for the very first …
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Role of plasma membrane ATPase4 in the pathophysiology of pulmonary arterial hypertension
… expression of PAH-associated receptors (BMPR2, ALK1, TGFβR1, Endoglin) was evaluated in lung RNA from PMCA4 wild-type and knockout mice by qPCR, showing no significant differences. In vitro, stimulation of human PAECs and HUVECs with TNF-α and cycloheximide (CHX) significantly reduced PMCA4 mRNA …
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Silencing of endoglin in rat hepatic stellate cells by RNA interference identifies endoglin as an important component of the transdifferentiation process
… amongst them genes such as a2-macroglobulin and ALK1. Based on their known functions, these candidates might contribute to the phenotype of the endoglin deficient HSC. Finally, stimulation experiments were performed in order to analyze the impact of endoglin on the TGF-beta and the BMP pathways. …
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Investigation of the therapeutic potential of recombinant BMP10 in an adult mouse model of HHT1 and the crosstalk between BMP and VEGF signalling
… in the Eng-iKOe lungs. Additionally, reduced Alk1 and Bmpr2 mRNA expression was fully rescued after pBMP10 treatment. In the in vitro analysis of human endothelial cells, BMP and VEGF ligands modulated common target genes such as FOS, ESM1, PlGF, and ET1, they will be further investigated in …
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Bone morphogenetic proteins 9 & 10 in pulmonary arterial hypertension
… PAH. BMPR-II forms a signalling complex, with ALK1 and endoglin, specific to endothelial cells which maintains vascular quiescence. BMP9 and BMP10 are the high affinity ligands for this signalling complex. Administering exogenous BMP9 has been shown to reverse disease in animal models of PAH, …