Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"ALIX"”.
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Regulation of The Escrt Function of Alix
… performs membrane invagination and abscission. ALIX is a widely expressed adaptor protein that is critically involved in three classical ESCRT-mediated processes, including MVB (multivesicular body) sorting, cytokinetic abscission and retroviral budding. Previous studies have demonstrated that …
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The evolved radical feminism of spoken word : Alix Olson, C.C. Carter, and Suheir Hammad
… I close-read three poems: "Womyn Before" by Alix Olson, "The Herstory of My Hips" by C.C. Carter, and "99 cent lipstick" by Suheir Hammad to discuss the manner in which each uses coalitions. Olson's poem provides an analysis of the performative and textual aspects of the poem as a way to …
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Investigating the Role of Stem-Loop 1 in the Assembly Process of HIV-1
… to enable budding. An ESCRT-associated protein, ALIX, is known to be capable of binding to the nucleocapsid (NC) domain of Gag using lipids or RNA as a ‘bridge’ in vitro. It was hypothesised that SL1 mutation disrupts an RNA-dependent interaction that occurs during virus assembly. Consistent with …
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The Roles Of Human Cytomegalovirus Tegument Proteins Pul48 And Pul103 During Lytic Infection
… of pUL103 in nuclei, delineation of a novel ALIX binding domain, and a role for pUL103 in ALIX localization in infected cells.</p>
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Mechanism and Functions of STING-Induced Noncanonical Autophagy
… STING-induced noncanonical autophagy induces ALIX-meditated ESCRT machinery recruitment to mitigate endolysosomal perturbation. Our study unraveled the multifaceted functions of STING-induced noncanonical autophagy in regulating endolysosomal homeostasis.
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Role of Ubiquitin and Ubiquitin Ligases in Retroviral Budding
… domains bind Tsg101, LxxLF or YPXL domains bind ALIX, and PPxY domains bind Nedd4-like HECT ligases, a class of ubiquitin ligase enzymes. The functional link between HECT ligases and the VPS pathway has not been defined, but multiple lines of evidence suggest that ubiquitin is generally important …
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Endosomal Sorting Complex Required for Transport (ESCRT): Investigation of the expression and functional roles in neurodegenerative diseases
… in other ESCRT proteins e.g. STAM1 and ALIX. Expression of ESCRT proteins was recapitulated in MND cellular models such as NCS-34 cells using tunicamycin treatment. Altering the expression of TSG101 and CHMP2B demonstrated changes in TDP-43 and mTOR expression including altered autophagy …
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Differential expression of proteins involved in sEV biogenesis and secretion in Parkinson’s disease and Dementia with Lewy bodies
… changes in key sEV proteins, particularly Alix. The SY5Y cell model was also used as a relevant in vitro model for Parkinson’s disease. Plasmid vector delivery was used to generate wild-type alpha-synuclein and familial point mutations of PD including the A53T-synuclein and E46K-synuclein …
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Isolation und Charakterisierung extrazellulärer Vesikel aus humanen CD8+- und γδ-T-Lymphozyten
… CD9 und CD81 sowie HSP70, Syntenin-1, TSG101 und ALIX. Insgesamt ergab sich ein weitgehend homogenes Spektrum an Proteinen in EV beider T-Zellpopulationen. Die Gen-Ontologie-Bewertung ergab eine deutliche Anreicherung von Proteinen, die mit extrazellulären Vesikeln und deren Biogenese, aber auch …
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Glycoprotein M and ESCRT in herpes simplex virus type 1 assembly
… HSV-1 infection is independent of TSG101 and/or ALIX. Data presented in this thesis demonstrate that CHMP4A/B/C proteins of the ESCRT-III complex are specifically crucial for HSV-1 secondary envelopment. Simultaneous depletion of CHMP4A/B/C proteins significantly inhibited HSV-1 replication. …
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Understanding Membrane Curvature Sensing
… I characterised the Endophilin binding motif of ALIX (ALG-2-interacting protein X) adaptor protein and of the GPCR $\alpha$2A adrenergic receptor. Comparison of SH3-peptide models resulted in a putative Endophilin recognition site.
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Policies And Procedures Perceived By School Leaders To Reduce Truancy In A Public Charter School
<p>This qualitative study examined the causes of student truancy and the policies and procedures established by one public charter school to reduce truancy. Eight participants were asked to discuss the policies and procedures of their school, CSS, and how they as school leaders contributed to the …
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Stratégies linguistiques et identitaires en Belgique : Approche interdisciplinaire des catégorisations, discours et représentations des usages en interaction de francophones vivant en Flandre et de néerlandophones vivant en Wallonie
Depuis le XIXème siècle qui a vu s’épanouir le concept de « peuple » sur des critères ethniques et linguistiques, les langues et les identités collectives sont souvent associées. Ce principe s’actualise notamment dans les identités régionales de Belgique. À l’heure où celles-ci prennent de plus en …
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Les enjeux de la distribution géographique des flux conteneurisés canadiens sur l'espace terrestre nord-américain
The objective of this research is to provide a geographical analysis of Canadian container flows and an assessment of the concept of trade diversion in the context of the North American free trade zone. Data are drawn from a commercial source that allow the competitive structure of the flows to be …
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Bioinformatics pipeline development for analyses of data generated by target capture-based Next-Generation Sequencing, to characterise mutations and the utility of using off-target sequences to detect genomic imbalances in Multiple Myeloma patients.
Greater Multiple Myeloma (MM) genomics understanding is required to improve patient care and outcomes, currently limited by available methods, especially regarding structural variant (SV)/copy number alteration (CNA) detection. This study aimed to exemplify target-capture Next-Generation Sequencing …
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Investigating the role of TRPC3 in the biogenesis of extracellular vesicles
… interactions with the syndecan-syntenin-ALIX axis in EV biogenesis. Proteomic analysis also evidenced the endosomal origin and enriched metastatic potential of TRPC3 activator-induced EVs, as well as presenting novel characterisation of the effect of DMSO on EV proteomes. Overall, these …
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Optical imaging methods for the study of disease models from the nano to the mesoscale
… protein EAP45 colocalises with Gag similarly to ALIX, a protein well known to be involved in HIV budding. However, upon deletion of EAP45’s N-terminus, its colocalisation with Gag was significantly impaired, highlighting the importance of this EAP45 domain in linking to Gag. Single particle …
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