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Showing 1 to 20 of 33 for “"ALIPHATIC AMINES"”.
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Radical methods for the synthesis of aliphatic amines
The aliphatic amine motif is a ubiquitous and uniquely important functional group in pharmaceutical agents and the development of ever more efficient synthetic methods for their synthesis is a continuous challenge. This thesis details the development of three new radical reactions for the synthesis …
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New strategies for the synthesis and functionalization of aliphatic amines
… chemicals into pharmacologically-privileged amines is a landmark challenge in organic synthesis. This thesis describes the development of three novel transition-metal catalyzed processes for the synthesis of alkylamines that attempts to meet this challenge. The first Pd-catalyzed methylene …
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New strategies for the synthesis and homologation of complex aliphatic amines
… and late-stage modification of complex alkylamines represents a significant and enduring challenge in synthetic chemistry. This is due to the ubiquity of this chemical motif in biologically active small molecules and therapeutic agents. This thesis describes the design and implementation of …
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Palladium-Catalysed Functionalisation of Csp3–H Bonds Directed by Aliphatic Amines
Synthetic transformations on medicinally-relevant aliphatic amines are valuable in the diversification of molecules designed as pharmaceutical agents. This thesis describes two Csp3–H functionalisation reactions, using native amines (secondary and tertiary) to direct C–H activation. Chapter 2 …
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Defining the substrate scope of DNAzyme catalysis for reductive amination with aliphatic amines
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2025-05-01
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A general catalytic β-C–H carbonylation of aliphatic amines to β-lactams
… general C–H carbonylation reaction of secondary aliphatic amines, which provides facile access to synthetically useful β-lactam products. The first part of the thesis explores the scope and limitations of this reaction. Whilst previous C(sp3)–H carbonylation methodologies were restricted to ‘Type …
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Palladium-mediated C–H Functionalization of Aliphatic Amines via High Valent Palladium(IV) Intermediates
… Pd-mediated C–H functionalization of unprotected aliphatic amines, in which the amine nitrogen coordinates to the Pd centre to promote cyclometalation to the key palladacycle intermediate. Specifically, research focused on the design and optimization of novel oxidants that would provide mild and …
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Toxicity of aliphatic amines on the embryos of zebrafish Danio rerio - experimental studies and QSAR
The toxicity of 36 aliphatic amines on the embryos of the zebrafish Danio rerio were investigated. The DarT (Danio rerio Toxicity assay) was used to determine the lethal concentrations within a 48 h static acute toxicity test. A QSAR (Quantitative Structure-Activity Relationship) was performed …
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Palladium-Catalysed Carbonylation of Aliphatic Amines and its Application in the Total Synthesis of Cylindricine C
… of catalytic C(sp3)–H carbonylation of secondary aliphatic amines. Chapter 2 describes the development of a general methyl C–H carbonylation of secondary aliphatic amines to form synthetically useful β-lactam building blocks. Amines exhibiting a range of substitution patterns around the nitrogen …
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ΕΠΙΔΡΑΣΗ ΤΩΝ ΑΜΙΝΩΝ ΣΤΙΣ ΔΟΜΙΚΕΣ ΚΑΙ ΚΑΤΑΛΥΤΙΚΕΣ ΙΔΙΟΤΗΤΕΣ ΤΗΣ ΓΛΥΚΟΓΟΝΙΚΗΣ ΦΩΣΦΟΡΥΛΑΣΗΣ Β
… OF PHOSPHORYLASE B, IN THE PRESENCE OF AMINES. THE AMINES STUDIED ARE THE ALIPHATIC AMINES, THE PHENOTHIAZINES AND THE POLYMYXINS. THESE AMINES IN THE PRESENCE OF AMP INDUCE A SIGNIFICANT ENHANCEMENT OF ENZYME ACTIVITY. THE BINDING CENTER OF PHOSPHORYLASE B FOR AMINES IS POSSIBLY LOCATED …
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Nanostructured Materials Prepared With Ultrasound
… sensing arrays for the identification of aliphatic amines. Further usefulness of USP is demonstrated in quantum dot synthesis. Previously, using organic precursor solutions containing high boiling point liquids, highly luminescent CdSe and CdTe quantum dots were prepared. In this study, …
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A novel photocatalytic strategy for complex aliphatic amine synthesis and the total synthesis of alkaloids (−) FR901483 and (+)-TAN1251C
… the synthesis and functionalization of aliphatic amines plays a central role in the field of visible light photoredox chemistry. In this thesis, the development of a novel, visible light mediated process for the synthesis of complex aliphatic amines is described. The novel multicomponent …
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ΜΕΛΕΤΗ ΕΠΙΦΑΝΕΙΑΚΩΝ ΙΔΙΟΤΗΤΩΝ ΚΑΙ ΚΑΤΑΛΥΤΙΚΗΣ ΔΡΑΣΤΙΚΟΤΗΤΑΣ ΠΑΡΑΣΚΕΥΑΣΜΑΤΩΝ ΥΔΡΟΞΕΙΔΙΩΝ ΤΟΥ ΑΡΓΙΛΙΟΥ
… AS PRECIPITATION AGENTS WERE USED THREE PRIMARY ALIPHATIC AMINES SUCH AS PROPYLAMINE, OCTYLAMINE AND DODECYLAMINE. THE PREPARED SAMPLES WERE FREEZE DRIED, A PROCESS THAT HAS THE ADVANTAGE TO OBTAIN MATERIALS WITH BETTER SURFACE PROPERTIES THAN CONVENTIONAL TECHNIQUES. OUR PURPOSE WAS TO STUDY THE …
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Understanding polyamine metabolism through transgenic manipulation in poplar suspension cultures
<p>Polyamines are low molecular weight aliphatic amines that are obligatory requirements for cell survival and growth. The commonly occurring polyamines in plants are putrescine, spermidine, and spermine. Suspension cultures of poplar (Populus nigra x maximowiczii), transformed with a mouse …
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Fundamental studies on 2,4,6-trichlorophenyl sulfonate esters
… conditions for reactions with both simple aliphatic amines and more challenging anilines have been found. The differing reactivity’s of the TCP and PFP sulfonate esters have been exploited in selective sulfonamide formation. The greater stability of TCP sulfonate in comparison to PFP …
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Antimalarial drug rescue through safety improvement: design, synthesis and evaluation of amaodiaquine analogues
… benzoxazole and pyridyl rings bearing different aliphatic amines and diamines. The chemistry involved aromatic nucleophilic substitution reactions and hydrogenation of nitro aromatic compounds. Benzothiazole and benzoxazole analogues with a tertiary protonatable nitrogen were found to possess …
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New applications of Imidazotetrazinone prodrugs. Synthesis and mechanistic investigation of novel imidazotetrazinones as prodrugs of aziridines and as traceless carriers for drug delivery to the central nervous system.
… towards the isocyanate group in the case of aliphatic amines; in contrast, anilinoethylisocyanates were synthesized unprotected. Substituents with a range of electron-withdrawing and electron-releasing properties were introduced at the p-position of the aniline ring. A 13C-labelled study …
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Novel P,N-Ligand Stabilized Transition Metal Complexes as Efficient Catalysts for Organic Syntheses
… as potential catalysts for the N-alkylation of amines with alcohols. After optimization of the reaction conditions by systematic variation of important parameters such as solvents, bases or catalyst loadings the possible substrate scope of this method was demonstrated. The obtained results …
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METAL-FREE SELECTIVE SP3 C-H IMINATION AND COVALENT POSTSYNTHETIC MODIFICATION OF POLYSTYRENE BY DIRECT C-H AMINATION
… enabling direct alkane C–H amination. Alkylamines are commonly found as natural products and bioactive compounds, and amino functionalization can improve the properties of commodity polymers. Transition-metal-catalyzed C–H amination has emerged as a powerful tool for C–N bond formation, but …
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