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Showing 1 to 20 of 39 for “"ALDH"”.

  1. Aldehyde dehydrogenases (ALDH) expression in cancer tissues as potential pharmacological targets for therapeutic intervention. Probing ALDH expression and function in 2D- and 3D-cultured cancer cell lines

    Elsalem, Lina M.I.University of Bradford2017

    The aldehyde dehydrogenase (ALDH) superfamily is gaining momentum in regard to stem cell and cancer research. However, their regulation and expression in the cancer microenvironment is poorly understood. The aim of this work was to understand the role of selected ALDH isoforms (1A1, 1A2, 1A3, 1B1, …

    bradford Repository record

  2. Aldehyde dehydrogenases (ALDH) expression in cancer tissues as potential pharmacological targets for therapeutic intervention. Probing ALDH expression and function in 2D- and 3D-cultured cancer cell lines

    Elsalem, Lina M.I.University of Bradford2017

    The aldehyde dehydrogenase (ALDH) superfamily is gaining momentum in regard to stem cell and cancer research. However, their regulation and expression in the cancer microenvironment is poorly understood. The aim of this work was to understand the role of selected ALDH isoforms (1A1, 1A2, 1A3, 1B1, …

    bradford Repository record

  3. Aldehyde dehydrogenases (ALDH) expression in cancer tissues as potential pharmacological targets for therapeutic intervention. Probing ALDH expression and function in 2D- and 3D-cultured cancer cell lines

    Elsalem, Lina M.I.University of Bradford2017

    The aldehyde dehydrogenase (ALDH) superfamily is gaining momentum in regard to stem cell and cancer research. However, their regulation and expression in the cancer microenvironment is poorly understood. The aim of this work was to understand the role of selected ALDH isoforms (1A1, 1A2, 1A3, 1B1, …

    bradford Repository record

  4. Design, Synthesis and Biological Evaluation of Chemical Probes Incorporating Aldehyde Dehydrogenase (ALDH) Recognition Motifs and Fluorescent Properties. An Investigation Towards the Development of ALDH-Affinic Fluorophores for Hypoxia Cell Tracking

    Ibrahim, Ali I.M.University of Bradford2017

    bradford Repository record

  5. Design, Synthesis and Biological Evaluation of Chemical Probes Incorporating Aldehyde Dehydrogenase (ALDH) Recognition Motifs and Fluorescent Properties. An Investigation Towards the Development of ALDH-Affinic Fluorophores for Hypoxia Cell Tracking

    Ibrahim, Ali I.M.University of Bradford2017

    bradford Repository record

  6. Expression of Aldehyde dehydrogenase (ALDH) in the breast stem cell line D492 and relations to stem cell properties

    Katrín Birna Pétursdóttir 1988-2015

    Aldehyde dehydrogenases (ALDH) are enzymes expressed in both normal and cancer stem cells (CSC). CSCs are hypothesized to arise from normal stem cells and acquire a malignant phenotype through series of genetic mutations. Current therapies often fail to eradicate CSCs causing metastatic relapse. …

    u-iceland Repository record

  7. Targeting Aldehyde Dehydrogenases in NF2-null Meningioma and Schwannoma

    Williams, Libby2025

    … overexpression of aldehyde dehydrogenase 1A1 (ALDH1A1) in NF2-null schwannoma. High expression of ALDH1A1, and the related isoform ALDH1A3 have been identified as markers of cancer stem cell activity and have been correlated with poor prognosis and chemoresistance in several cancers. This …

    plymouth Repository record

  8. The interaction of disulfiram and H2S metabolism in inhibition of aldehyde dehydrogenase activity and liver cancer cell growth

    Read, EthanLaurentian University of Sudbury2021

    … decades. DSF inactivates aldehyde dehydrogenase (ALDH) by modifying its cysteine residue(s). ALDH is recently identified as a cancer stem cell marker, facilitating cell self-renewal and tumour-initiating capacity. Hydrogen sulphide (H2S) as a new gasotransmitter regulates various cellular …

    laurentian Repository record

  9. IN-VITRO PK/PD PROFILING AND MODELING OF THE ANTI-SICKLING AGENTS, 5-HYDROXYMETHYL FURFURAL (5-HMF) AND NOVEL SYNTHETIC ALLOSTERIC EFFECTORS OF HEMOGLOBIN (AEH) IN HUMAN WHOLE BLOOD

    Parikh, Apurvasena2016

    … to be substrates for aldehyde dehydrogenase (ALDH) in the liver and red blood cells (RBC). Methods. Biopharmaceutical assessments were made for AEH, using calculated physicochemical properties. Their in-vitro hepatic metabolism (mediated by ALDH) was characterized using hepatic cytosol, and …

    vcu Repository record

  10. Towards the development of fluorescent probes targeting aldehyde dehydrogenase (ALDH) in cancer. Expression and epigenetic modulation of ALDH1A1, ALDH2 and ALDH3A1 in selected in vitro models.

    Cosentino, LauraUniversity of Bradford2012

    … and measurement of high aldehyde dehydrogenase (ALDH) activity has been defined as a characteristic of stem cells (SCs). In this study, a library of novel small molecules (1,4-di-substituted acetalanthraquinones, AAQs), containing an acetal group as protected aldehyde functionality, was designed …

    bradford Repository record

  11. Towards the development of fluorescent probes targeting aldehyde dehydrogenase (ALDH) in cancer. Expression and epigenetic modulation of ALDH1A1, ALDH2 and ALDH3A1 in selected in vitro models.

    Cosentino, LauraUniversity of Bradford2012

    … and measurement of high aldehyde dehydrogenase (ALDH) activity has been defined as a characteristic of stem cells (SCs). In this study, a library of novel small molecules (1,4-di-substituted acetalanthraquinones, AAQs), containing an acetal group as protected aldehyde functionality, was designed …

    bradford Repository record

  12. Exploring the heterogeneity of the hematopoietic stem and progenitor cell pool in cord blood

    Frändberg, Sofia2017

    … (SP), Aldehyde Dehydrogenase activity (ALDH) and the expression of the surface protein CD34 and secondly for the definition of viable and apoptotic cells in the ALDH and CD34 positive populations respectively. Finally, we screened for bi-omarkers in CB plasma that may predict the HSPC …

    goteborg Repository record

  13. Investigating the expression and function of aldehyde dehydrogenases in prostate cancer. Probing the expression and function of ALDHs using chemical probes, drugs and siRNA

    Sadiq, MariaUniversity of Bradford2017

    … and drug resistance. Aldehyde dehydrogenases (ALDHs) have been used in some tumour types as CSC markers. Their high expression and high functional activity found in CSCs is also associated with drug resistance. Emerging evidence suggests deregulation of certain ALDH isoforms have implications …

    bradford Repository record

  14. Investigating the expression and function of aldehyde dehydrogenases in prostate cancer. Probing the expression and function of ALDHs using chemical probes, drugs and siRNA

    Sadiq, MariaUniversity of Bradford2017

    … and drug resistance. Aldehyde dehydrogenases (ALDHs) have been used in some tumour types as CSC markers. Their high expression and high functional activity found in CSCs is also associated with drug resistance. Emerging evidence suggests deregulation of certain ALDH isoforms have implications …

    bradford Repository record

  15. Enzymology of butanol formation in Clostridium Beijerinckii

    Yan, Run-TaoVirginia Tech1991

    … CoA-acylating aldehyde dehydrogenase (ALDH) was purified to near homogeneity. The ALDH showed a native M.. of 100,000, and a subunit Mr of 55,000. ALDH could use either NAD(H) or NADP(H) as the coenzyme. ALDH was oxygenlabile. The O₂-inactivated enzyme could be reactivated by incubating …

    vt Repository record

  16. Humane Alkoholdehydrogenasen und Aldehyddehydrogenasen : Bedeutung für den Metabolismus von Methylpyrenderivaten und von 5-(Hydroxymethyl)-2-furfural

    Kollock, RonnyUniversität Potsdam

    … (ADH) und Aldehyddehydrogenasen (ALDH) zur Carbonsäure könnte einen wichtigen Detoxifizierungsweg in Konkurrenz zur Aktivierung durch Sulfotransferasen (SULT) darstellen, was für 1-Hydroxymethylpyren in der Ratte bereits gezeigt wurde (Ma, L., Kuhlow, A. & Glatt, H. (2002). …

    potsdam-diss Repository record

  17. Investigation of the anticancer activity and molecular mechanisms of Disulfiram in Glioblastoma Multiforme

    Kannappan, Vinodh2015

    … (HIFs), NF-B and aldehyde dehydrogenase (ALDH) together orchestrate the stemness and chemoresistance in hypoxia induced CSCs. But the insights on the mechanisms still remain obscure. In this study we used an in vitro GBM CSC and hypoxia model along with NF-B-p65 and HIF transfected GBM …

    wlv Repository record

  18. The Role of Inflammatory Lipid Mediators on Colon Cancer Initiating Cells (CICs)

    Bellamkonda, KishanDepartment of Laboratory Medicine, Lund University2015

    … this end, we identified the CICs on the basis of ALDH expression and evaluated their in vitro characteristics like colony formation, radio or chemoresistance and in vivo tumorigenic properties in the presence of LTD4 or PGE2. We showed that LTD4 and PGE2 enriched the ALDH+ cell population and …

    lund Repository record

  19. The role of cancer stem cells in osteosarcoma

    Jenks, A.University of Westminster2014

    … The intracellular enzyme aldehyde dehydrogenase (ALDH) and tyrosine kinase receptor CD117 were found to be heterogeneously expressed amongst the cell lines. All cell lines when plated at low density could recapitulate the colony hierarchies based on variation in colony morphology (holoclones, …

    westminster Repository record

  20. Explorative studies to understand if aldehyde dehydrogenase (ALDH) expression in colon cancer can be exploited as a target for therapeutic intervention. Expression profiling of ALDH7A1 in colorectal cancer

    Magaji, Abdullahi D.University of Bradford2022

    bradford Repository record

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