Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"AKT3"”.
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Overexpression of active AKT3 induces differential binding of coregulator proteins to the estrogen receptor as a possible mechanism of Tamoxifen resistance
… previously reported that expression of active Akt3 in MCF-7 breast cancer cells results in estrogen-independent tumors that are actually stimulated to grow after tamoxifen treatment. We hypothesize that this tamoxifen resistance may be attributed to binding of different co-regulator proteins …
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Matriptase/pdgf D/beta-Pdgfr Signaling Axis In Human Prostate Cancer: The Role Of Pten In The Regulation Of Pdgf D Expression
… downstream effectors of PI3K, increased Akt3 expression was most prominent in PTEN-/- cells. These results suggest a molecular basis for activation of PDGF D/?-PDGFR signaling driven by the loss of PTEN, a frequent occurrence in human prostate cancer. Similarly, PTEN/Akt3 expression …
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Akt2 Redox-regulation in Breast Cancer and Diabetes
… three mammalian isoforms of Akt (Akt1, Akt2, and Akt3) share common structural and functional characteristics. Despite their common features and shared activation pathway, the Akt isoforms exhibit divergent regulation of downstream processes. The molecular basis for these differences is unknown. …
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Yap1 Expression Predicts Sensitivity to Dual Akt/P70S6K Inhibition In Ovarian and Uterine Malignancies
… MSC2363318A, which is a novel inhibitor of AKT1, AKT3, and P70S6K.</p> <p><strong>Experimental Design: </strong>Orthotopic murine models of ovarian and uterine cancer were utilized to study the effect of MSC2363318A on survival and regression. Moreover, <em>in vitro</em> experiments (MTT, Western …
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Ehrlichia chaffeensis TRP32 is a Nucleomodulin that Regulates Host Gene Expression and Post-Translational Modifications Determine its Localization and Function
… and inflammation such as FOS and JUN, AKT3 and NRAS, and non-coding RNA genes, miRNA 21 and miRNA 142. TRP32 target genes were differentially regulated during infection, and direct repression/activation of these genes by TRP32 was confirmed in vitro with a cellular luciferase reporter …
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The regulation of the T-box transcription factor TBX3 in Luminal A breast cancer
… isoforms have been identified viz AKT1, AKT2 and AKT3 and elevated AKT1 and AKT2 kinase activity has been reported in 30-40% of oestrogen receptor-positive breast carcinomas. Given the overlapping oncogenic roles between AKT and TBX3 in breast cancer, and because TBX3 has previously been shown to …
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Exploiting a novel organotypic model of SOX2-driven early squamous lung cancer to identify potential routes to chemoprevention
Lung cancer is a devastating disease and is the leading cause of cancer related death globally. Squamous cell lung cancer (SQC) accounts for around 25% of all lung cancer diagnoses. Better strategies for the early detection, prevention and treatment of lung cancer are urgently needed. Using a novel …
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Effects of prepartum dietary energy and lipid supplementation on hepatic transcriptome profiles in dairy cows during the transition period
… Genes associated with cell growth (mTOR, RPTOR, AKT3, TP53) also had greater (Diet × Time; P < 0.05) expression in OVE after parturition. Overall, results indicated that postpartal negative EBAL induced by prepartal OVE was associated with hepatic pro-inflammatory and pro-stress upregulation. In …