Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"AKT-1"”.
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DNA Damage-dependent Regulation and Function of akt-1 in Caenorhabditis elegans
… This pathway ultimately controls the action of Akt homologues on the forkhead transcription factor DAF-16. The C. elegans Akt orthologue akt-1 also negatively regulates the DNA damage-dependent apoptosis of worm germ cells by indirectly interfering with activation of the key transcription factor …
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Quantitative Proteinexpressionsanalysen in den klinisch-pathologischen Subtypen Gastrointestinaler Stromatumoren (GIST)
… der mesenchymalen Tumoren des Gastrointestinaltraktes und machen in dieser Gruppe ca. 70 % aus. Der klinische Verlauf von GIST ist von bestimmten klinisch-pathologischen Parametern wie der anatomischen Lokalisation, der Tumorgröße, der Mitosenzahl und dem Mutationsstatus abhängig. Die Zielsetzung …
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Proteomic identification of putative biomarkers of neo-adjuvant chemotherapy resistance in luminal (ER+) breast cancer
… using IPA; 13 DEPs were mapped onto the PI3K/AKT pathway. Clinical validation in a pilot series of archival samples revealed AkT-1 Ser473 and FAKY397 alongside the previously identified and validated 14-3-3 theta/tau, and tBID to be significantly associated with chemotherapy …
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Chronic Hypoxia and Cardiovascular Dysfunction in Sleep Apnea Syndrome
… 3-kinase (PI3K)/protein kinase B (Akt-1) transduction network. To this end, 7 medically diagnosed OSA patients (3 male, 4 female), mean age 48 years and 7 apparently healthy control subjects (3 male, 4 female), mean age 42 years, underwent baseline venous blood draws and maximal …
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The Role of IGF-1 and Notch Signaling in Thoracic Malignancies.
… the well-established role played by the IGF-1/Akt-1 axis in thoracic malignancies, we focused our research on the role of Notch signaling in cancers of the thorax. Notch-1 signaling has been shown to be required for the growth of SV40-transformed HM. We therefore expanded the studies of the …
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The effect of RAN inhibition on human colorectal cancer cells (CRC)
… signalling molecules such as p- Erk 1/2 and p- Akt were upregulated after MBZ treatment and exert inhibition on Akt 1/2/3 and VEGFR1/2 mRNA levels. In conclusion; MBZ which is a Ran inhibitor, has significantly reduced proliferation, colony formation, and migration in colorectal cell lines with …
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Regulation of the Ras Signaling Network in C. Elegans Development
… 1˚-promoting AGE-1/PI3-Kinase-PDK-1/PDK-AKT-1/Akt cascade. Animals without RGL-1 experience 15-fold higher rates of VPC patterning errors compared to the wild type. Yet VPC patterning in RGL-1 deletion mutants is not more sensitive to environmental perturbations. We propose that RGL-1 …
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Targeting the Notch-1/IGF-1R/Akt Axis in at Orthotopic Model of Advanced Non-Small Cell Lung Cancer
… by positively regulating IGF-1R to activate the Akt-1 pathway. Therefore, the overall hypothesis is that an inhibitor of Notch activation, such as γ-secretase inhibitor (GSI) MRK-003; or a fully humanized antibody against the human IGF-1R that promotes the receptor degradation (IGF-1R inhibitory …
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The role of T-box transcription factor TBX3 in rhabdomyosarcoma
… stability, and that oncogenic c - Myc and AKT 1 positively regulat e TBX3 levels in ERMS. This, albeit preliminary data, suggest that Hsc70, c - Myc and AKT1 are responsible, in part, for the overexpression of TBX3 in ERMS. Together findings from this study implicate TBX3 as an oncogene in …
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The proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia
… the plasma kallikrein-kinin system (KKS), the AKT-1 pathway, the MAPK pathways, the adenylate kinase system and involvement in the CD40-dependant activation of B-CLL cells. One of the protein targets found (kininogen) was increased by over two-fold in three independent clinical samples after …
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Molecular Mechanisms of Hepatitis C Virus- Associated Steatosis
… HCV core was also able to increase activity of Akt 1 and Akt2; inhibition of Akt activity resulted in decreased SREBP-1 activity thereby indicating that HCV core partially mediates SREBP-1 via Akt. Further experiments examined the role of another HCV protein, NS2, in these same lipid metabolism …
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Modulation of touch sensitivity in Caenorhabditis elegans
… signaling and integrin signaling converge on AKT-1 and DAF-16, which modulate touch sensitivity by regulating the transcription of mfb-1, an E3 ubiquitin ligase expressed in the TRNs. MFB-1 regulates the amount of MEC-4 channel on the plasma membrane, thus modulating touch sensitivity. …