Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"AKT inhibitors"”.
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PREPARATION AND EVALUATION OF DECONSTRUCTION ANALOGS OF 7-DEOXYKALAFUNGIN AS AKT INHIBITORS
… have been recently found to be selective inhibitors of the serine-threonine kinase AKT/PKB. AKT/PKB plays a major role in tumorigenesis, hence these compounds have a great potential to act as anti-cancer agents. They act by a novel bioreductive alkylation mechanism of inhibition of …
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Συστηματική ανασκόπηση: Ο ρόλος των AKT αναστολέων στον μεταστατικό καρκίνο του μαστού / Role of AKT inhibitors in metastatic breast cancer: A systematic review
… Η απορρύθμιση του μονοπατιού σηματοδότησης PI3K/AKT/mTOR αποτελεί συχνό μοριακό γεγονός στον καρκίνο του μαστού και έχει συσχετιστεί με την εξέλιξη της νόσου και την ανάπτυξη θεραπευτικής αντίστασης. Σκοπός της παρούσας συστηματικής ανασκόπησης ήταν η αξιολόγηση της αποτελεσματικότητας και της …
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1á,25(OH)2-VITAMIN D3 IN PROSTATE: INTERSECTION WITH AKT/PTEN AXIS AND ROLE IN SENESCENCE
The PI3K-AKT pathway is frequently activated in prostate cancer and can lead to downregulation of p21 and p27 levels and function. 1-alpha, 25-dihydroxy vitamin D<sub>3</sub> (1á,25(OH)<sub>2</sub>D<sub>3</sub>) inhibits proliferation of multiple cancer cell types, including prostate cancer cells, …
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Evaluation of the therapeutic potential of Akt inhibition in a translational model of histiocytic sarcoma
… with no available effective treatment options. Akt signaling and proteasome dysfunction have been implicated in the pathogenesis of the disease, both in humans and dogs. Our work aims to investigate the importance of the Akt signaling pathway and evaluate the potential of Akt-targeted therapy in …
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Mechanismen der Durchbrechung der sekundären Antiöstrogenresistenz durch GnRH-Analoga in Mammakarzinomzellen
… Tamoxifen ein großes Problem dar. Die Aktivierung verschiedener Signaltransduktionskaskaden von Wachstumsfaktorrezeptoren und deren Querverknüpfung mit der Signaltransduktion des Östrogenrezeptors sind oft Ursache dieses Wirkungsverlustes, der sekundäre Antiöstrogenresistenz genannt …
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Causes and Consequences of Genomic Instability in Prostatic Carcinogenesis
… with HPIN and the use of targeted agents such as AKT inhibitors and telomerase inhibitors. In more advanced disease, translational application of this work has enabled a clinical trial of cytarabine in the treatment of metastatic hormone refractory prostate cancer.
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Molecular Mechanisms Of Pressure-Stimulated Cancer Cell Signaling
… increase is abolished in the presence of NF-kB inhibitors. Further studies showed that increased pressure activates protein kinase C alpha/beta increases IKK and IkB phosphorylation, cyclin D1 expression and increased S-phase fractions. Immunohistochemical staining for NF-kB, IkB and cyclin D1 …
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SGK3 activity and regulation in PI3K-Akt pathway inhibitor resistance in breast cancer
The PI3K-Akt signalling pathway is central to cell proliferation and growth, and hyperactivating mutations in this pathway are found in a large number of cancers. Downstream of PI3K, Akt is heavily studied, however the highly related SGK family of protein kinases have recently been identified as …
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Yap1 Expression Predicts Sensitivity to Dual Akt/P70S6K Inhibition In Ovarian and Uterine Malignancies
<p><strong>Purpose: </strong>The PI3K/AKT/P70S6K pathway is an attractive therapeutic target in ovarian and uterine malignancies due to its high rate of dysregulation and key roles in tumor growth. Here, we examined the biological effects of MSC2363318A, which is a novel inhibitor of AKT1, AKT3, …